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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Ubiquitin protein ligase E3 component n-recognin 3

UBR3, ZNF650
Top mentioned proteins: Ubiquitin, UBR1, HAD, SET, UBR2
Papers on UBR3
Cardiac Nav 1.5 is modulated by ubiquitin protein ligase E3 component n-recognin UBR3 and 6.
New
Chen et al., Shanghai, China. In J Cell Mol Med, Sep 2015
Individual knockdown of UBR3 or UBR6, but not of other UBR members, significantly increased Nav 1.5 protein levels in neonatal rat ventricular myocytes, and this effect was verified in HEK293T cells expressing Nav 1.5 channels.
Ubr3 E3 ligase regulates apoptosis by controlling the activity of DIAP1 in Drosophila.
Lin et al., Wenzhou, China. In Cell Death Differ, 2014
Here, we demonstrate that Drosophila CG42593 (ubr3), encoding the homolog of mammalian UBR3, has an essential role in regulating the apoptosis pathway.
Genetic Variants Underlying Risk of Intracranial Aneurysms: Insights from a GWAS in Portugal.
Oliveira et al., Lisbon, Portugal. In Plos One, 2014
rs4667622 (between UBR3 and MYO3B), rs6599001 (between SCN11A and WDR48), rs3932338 (214 kilobases downstream of PRDM9), and rs10943471 (96 kilobases upstream of HTR1B) were associated with IA (unadjusted allelic chi-square tests) in the datasets tested (discovery: 6.84E-04≤P≤1.92E-02,
Reconstructing the coding and non-coding RNA regulatory networks of miRNAs and mRNAs in breast cancer.
Chen et al., Nanjing, China. In Gene, 2014
Finally, after verified by test sets, three indexes, including area under the ROC curve (AUC), Accuracy and Matthews correlation coefficients (MCCs), indicated only 4 modules (miR-106b-CIT-KPNA2-miR-93, miR-106b-POLQ-miR-93, miR-107-BTRC-UBR3-miR-16 and miR-200c-miR-16-EIF2B5-miR-15b) had discriminated ability and their classification performance were prior to that of the single molecules.
Ubiquitin ligase UBR3 regulates cellular levels of the essential DNA repair protein APE1 and is required for genome stability.
GeneRIF
Dianov et al., Oxford, United Kingdom. In Nucleic Acids Res, 2012
Knockout of the Ubr3 gene in mouse embryonic fibroblasts leads to an up-regulation of the cellular levels of APE1 protein and subsequent genomic instability.
Confirmation of genomewide association signals in Chinese Han population reveals risk loci for ischemic stroke.
Wang et al., Wuhan, China. In Stroke, 2010
In addition, both ZNF650 rs10204475 and intergenic single nucleotide polymorphism rs10486776 were associated with ischemic stroke as well as independent of traditional cardiovascular risk factors in dominant models (OR=1.47,
The substrate recognition domains of the N-end rule pathway.
Kwon et al., Pittsburgh, United States. In J Biol Chem, 2009
Pull-down assays with recombinant UBR proteins suggest that 570-kDa UBR4 and 300-kDa UBR5 bind N-degron, whereas UBR3, UBR6, and UBR7 do not.
Biochemical and genetic studies of UBR3, a ubiquitin ligase with a function in olfactory and other sensory systems.
GeneRIF
Kwon et al., Pittsburgh, United States. In J Biol Chem, 2007
the UBR box of UBR3 may recognize small compounds that modulate the targeting, by this E3, of its currently unknown substrates
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