gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

UBR1 Ubr1p

UBR1, JBS, Ubr1p, E3alpha
The N-end rule pathway is one proteolytic pathway of the ubiquitin system. The recognition component of this pathway, encoded by this gene, binds to a destabilizing N-terminal residue of a substrate protein and participates in the formation of a substrate-linked multiubiquitin chain. This leads to the eventual degradation of the substrate protein. The protein described in this record has a RING-type zinc finger and a UBR-type zinc finger. Mutations in this gene have been associated with Johanson-Blizzard syndrome. [provided by RefSeq, Jul 2008] (from NCBI)
Papers using UBR1 antibodies
Toward the structural genomics of complexes: crystal structure of a PE/PPE protein complex from Mycobacterium tuberculosis.
Supplier
Kursula Inari, In PLoS ONE, 2005
... using a commercial kit (JBS Methylation Kit, from Jena Bioscience GmbH, Germany), following the ...
Papers on UBR1
A network of ubiquitin ligases is important for the dynamics of misfolded protein aggregates in yeast.
GeneRIF
Caplan et al., New York City, United States. In J Biol Chem, 2012
Data show that ubiquitin-protein ligases Ubr1 and Ubr2 have opposing roles in Ste11DeltaNK444R-GFP aggregation.
Recurrent Johanson-Blizzard syndrome in a triplet pregnancy complicated by urethral obstruction sequence: a clinical, molecular, and immunohistochemical approach.
GeneRIF
Rehder et al., Marburg an der Lahn, Germany. In Pediatr Dev Pathol, 2012
Testing the fetus and the affected sibling with recurrent Johanson-Blizzard syndrome revealed a homozygous truncating mutation in UBR1.
Ser(120) of Ubc2/Rad6 regulates ubiquitin-dependent N-end rule targeting by E3{alpha}/Ubr1.
GeneRIF
Haas et al., New Orleans, United States. In J Biol Chem, 2011
Ubc2/Rad6 ser(120) regulates ubiquitin-dependent N-end rule targeting by E3{alpha}/Ubr1
The N-end rule pathway is mediated by a complex of the RING-type Ubr1 and HECT-type Ufd4 ubiquitin ligases.
Impact
GeneRIF
Varshavsky et al., Pasadena, United States. In Nat Cell Biol, 2010
Study shows that the RING-type Ubr1 E3 and the HECT-type Ufd4 E3 interact, both physically and functionally.
Ubiquitin ligases of the N-end rule pathway: assessment of mutations in UBR1 that cause the Johanson-Blizzard syndrome.
GeneRIF
Zenker et al., Pasadena, United States. In Plos One, 2010
Results confirmed the relevance of specific missense UBR1 alleles to JBS, and suggested that a residual activity of a missense allele is causally associated with milder variants of JBS.
share on facebooktweetadd +1mail to friends