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Ubiquitin-conjugating enzyme E2N

ubiquitin-conjugating enzyme E2N
mediates ubiquitin-dependent proteolytic pathway; forms a thiolester linkage between the active site cysteine and the ubiquitin, supports conjunction with a third protein, ubiquitin-protein ligase (E3) [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: Ubiquitin, fibrillin-1, ToF, CAN, alpha-Synuclein
Papers on ubiquitin-conjugating enzyme E2N
Involvement of ubiquitin-proteasome system in icariin-induced cardiomyocyte differentiation of embryonic stem cells using two-dimensional gel electrophoresis.
Lou et al., Hangzhou, China. In J Cell Biochem, 2011
MALDI-TOF/MS showed that icariin treatment resulted in the induction of five ubiquitin-proteasome system (UPS)-related proteins, such as ubiquitin carboxy-terminal hydrolase L1 (UCH-L1), ubiquitin-conjugating enzyme E2N, proteasome 26S, proteasome subunit-alpha type 6, and proteasome subunit-alpha type 2 in the differentiated cardiomyocytes.
Poly-(ADP-ribose) polymerase-1 is necessary for long-term facilitation in Aplysia.
Schacher et al., New York City, United States. In J Neurosci, 2009
Moreover, the expression of both the AprpL27a (Aplysia ribosomal protein L27a) and the ApE2N (Aplysia ubiquitin-conjugating enzyme E2N) mRNAs also increased after 5-HT.
Detection of autoantibodies against cyclophilin A and triosephosphate isomerase in sera from breast cancer patients by proteomic analysis.
Nakamura et al., Yamaguchi, Japan. In Electrophoresis, 2009
The matched protein spots on 2-DE gels were digested and used for LC-MS/MS analysis, and identified as cyclophilin A (peptidyl-prolyl cis-trans isomerase A), triosephosphate isomerase and ubiquitin-conjugating enzyme E2N.
[Proteome analysis on the mechanism of electroacupuncture in relieving acute spinal cord injury at different time courses in rats].
Li et al., Beijing, China. In Zhen Ci Yan Jiu, 2009
48 h vs 24 h, 3 more differential proteins were identified, i.e., dihydrolipoamide dehydrogenase, malate dehydrogenase 1, and glyceraldehyde-3-phosphate dehydrogenase (GAPDH); but two proteins disappeared, i.e., nucleoside diphosphate kinase, and ubiquitin-conjugating enzyme E2N.
Comparative proteomic analysis of brains of naturally aging mice.
Liu et al., Beijing, China. In Neuroscience, 2008
In particular, decrease of proteasome alpha subunits 3/6, ubiquitin carboxyl-terminal esterase L3, valosin-containing protein and calreticulin may be responsible for the declination of protein quality control; glutamate dehydrogenase 1, isocitrate dehydrogenase 1 and ubiquinol cytochrome c reductase core protein 2 for the shortage of energy and reducing agent; ubiquitin-conjugating enzyme E2N and heterogeneous nuclear ribonucleoprotein A2/B1 for the increase of DNA damage and transcription detuning; calbindin 1 and amphiphysin for the disturbance of synaptic transport and ion signals.
Proteomic profiling of proteins associated with methamphetamine-induced neurotoxicity in different regions of rat brain.
Luo et al., Guangzhou, China. In Neurochem Int, 2008
The proteins identified by tandem mass spectrometry were Cu, Zn superoxide dismutase, dimethylarginine dimethylaminohydrolase 1, alpha synuclein, ubiquitin-conjugating enzyme E2N, stathmin 1, calcineurin B, cystatin B, subunit of mitochondrial H-ATP synthase, ATP synthase D chain, mitochondrial, NADH dehydrogenase(ubiquinone) Fe-S protein 8, glia maturation factor, beta, Ash-m, neurocalcin delta, myotrophin, profiling IIa, D-dopachrome tautomerase, and brain lipid binding protein.
Proteomic analysis on the alteration of protein expression in the placental villous tissue of early pregnancy loss.
Huang et al., Hangzhou, China. In Biol Reprod, 2006
Anomalies of these proteins, including three principal antioxidant enzymes (copper/zinc-superoxide dismutase, peroxiredoxin 3, and thioredoxin-like 1 protein), S100 calcium binding protein, galectin-1, chorionic somatomammotropin hormone 1, transthyretin, fas inhibitory molecule, eukaryotic translation elongation factor, RNA-binding protein, ubiquitin-conjugating enzyme E2N, and proteasome beta-subunit, indicate widespread failure in cell regulations and processes such as antioxidative defense, differentiation, cell proliferation, metabolism, apoptosis, transcription, and proteolysis in early pregnancy loss.
Endogenous alpha-synuclein is induced by valproic acid through histone deacetylase inhibition and participates in neuroprotection against glutamate-induced excitotoxicity.
Chuang et al., Bethesda, United States. In J Neurosci, 2006
alpha-Syn knockdown also exacerbated glutamate neurotoxicity, stimulated the expression of the proapoptotic gene ubiquitin-conjugating enzyme E2N, and downregulated the expression of the anti-apoptotic gene Bcl-2.
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