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Ubiquitin specific peptidase 1

Ubiquitin Thiolesterase, SGT1, SGT, UBP, GCR2
This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. The protein specifically deubiquitinates a protein in the Fanconi anemia (FA) DNA repair pathway. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Ubiquitin, CAN, ACID, Hsp90, V1a
Papers on Ubiquitin Thiolesterase
Endoplasmic reticulum stress responses function in the HRT-mediated hypersensitive response in Nicotiana benthamiana.
New
Park et al., Taejŏn, South Korea. In Mol Plant Pathol, Feb 2016
BiP4/5 silencing significantly down-regulated HRT at the mRNA and protein levels and affected SGT1 and HSP90 expression.
Characterization and transcriptional profile of genes involved on glycoalkaloid biosynthesis in new varieties of Solanum tuberosum L.
New
Frazzon et al., In J Agric Food Chem, Feb 2016
The goal of this study was to evaluate the relationship between total glycoalkaloid content (TGA) and the expression of GAMEs, SGT1 and SGT3 genes in potato tubers.
Insulin-like growth factor-1 as an important endogenous growth factor for the recovery from impaired urethral continence function in rats with simulated childbirth injury.
New
Yoshimura et al., Pittsburgh, United States. In J Urol, Feb 2016
At 7, 14 and 21 days after VD, the effect of JB-1 treatment was examined by functional analyses (leak point pressure; LPP, urethral baseline pressure; UBP and urethral responses during passive increments in intravesical pressure) and molecular analyses in urethral tissues (phosphorylation of Akt, apoptotic changes and peripheral nerve density using Western blotting and immunohistochemistry).
Glucocorticoid receptors, brain-derived neurotrophic factor, serotonin and dopamine neurotransmission are associated with interferon-induced depression.
New
Martín-Santos et al., Barcelona, Spain. In Int J Neuropsychopharmacol, Jan 2016
We genotyped several functional polymorphisms of interleukin-28 (IL28B), indoleamine 2,3-dioxygenase (IDO-1), serotonin receptor-1A (HTR1A), catechol-O-methyl transferase (COMT), glucocorticoid receptors (GCR1 and GCR2), brain-derived neurotrophic factor (BDNF) and FK506 binding protein 5 (FKBP5) genes.
HSP90 regulates temperature-dependent seedling growth in Arabidopsis by stabilizing the auxin co-receptor F-box protein TIR1.
New
Estelle et al., San Diego, United States. In Nat Commun, Dec 2015
In addition, we show that HSP90 and the co-chaperone SGT1 each interact with TIR1, confirming that TIR1 is an HSP90 client.
Angiogenesis in salivary gland tumors: from clinical significance to treatment.
Review
New
Klijanienko et al., Athens, Greece. In Expert Opin Ther Targets, Jun 2015
Their diversity in terms of morphology and clinical course makes defining risk factors difficult, while the molecular steps responsible for SGT development remain unclear.
Deubiquitylating enzymes and their emerging role in plant biology.
Review
Nagel et al., Freising, Germany. In Front Plant Sci, 2013
Here, we will discuss the five different DUB families (USP/UBP, UCH, JAMM, OTU, and MJD) and their known biochemical and physiological roles in plants.
The gene Sr33, an ortholog of barley Mla genes, encodes resistance to wheat stem rust race Ug99.
Impact
Lagudah et al., Canberra, Australia. In Science, 2013
The wheat Sr33 gene functions independently of RAR1, SGT1, and HSP90 chaperones.
Overexpression of a novel cell cycle regulator ecdysoneless in breast cancer: a marker of poor prognosis in HER2/neu-overexpressing breast cancer patients.
GeneRIF
Band et al., Omaha, United States. In Breast Cancer Res Treat, 2012
Ecd as a novel marker for breast cancer progression and show that levels of Ecd expression predict poorer survival in Her2/neu overexpressing breast cancer patients.
USP1 regulates AKT phosphorylation by modulating the stability of PHLPP1 in lung cancer cells.
GeneRIF
Yuepeng et al., Xinxiang, China. In J Cancer Res Clin Oncol, 2012
data identified a novel USP1-PHLPP1-Akt signaling axis, and decreased USP1 level in lung cancer cells may play an important role in lung cancer progress.
The HSP90 complex of plants.
Review
Shirasu et al., Yokohama, Japan. In Biochim Biophys Acta, 2012
In the process of chaperoning NLR proteins, co-chaperones, RAR1 and SGT1 function together with HSP90.
Serum HER2/ECD value in stage I and II early breast cancer: need of a lower cut-off?
GeneRIF
Mihaljevic et al., Zagreb, Croatia. In Wien Klin Wochenschr, 2011
Serum HER2/ECD concentration of >/=7.7 ng/ml has possible diagnostic value in stage I and II breast cancer. It should not be used as a determinant of HER2 positivity.
Two nuclear localization signals in USP1 mediate nuclear import of the USP1/UAF1 complex.
GeneRIF
Rodriguez et al., Leioa, Spain. In Plos One, 2011
USP1 and UAF1 form a complex in the cytoplasm that subsequently translocates to the nucleus through import mediated by USP1 nuclear localization signals.
The membrane fusion enigma: SNAREs, Sec1/Munc18 proteins, and their accomplices--guilty as charged?
Review
Südhof et al., Dallas, United States. In Annu Rev Cell Dev Biol, 2011
SNARE maintenance in a functional state depends on two chaperone systems (Hsc70/αCSP/SGT and synuclein); defects in these systems lead to neurodegeneration.
Synaptic vesicle exocytosis.
Review
Rizo et al., Stanford, United States. In Cold Spring Harb Perspect Biol, 2011
Fusion-competent conformations of SNARE proteins are maintained by chaperone complexes composed of CSPα, Hsc70, and SGT, and by nonenzymatically acting synuclein chaperones; dysfunction of these chaperones results in neurodegeneration.
USP1 deubiquitinates ID proteins to preserve a mesenchymal stem cell program in osteosarcoma.
Impact
GeneRIF
Dixit et al., San Francisco, United States. In Cell, 2011
Study shows that the deubiquitinating enzyme USP1 promotes ID protein stability and stem cell-like characteristics in osteosarcoma.
CSPα promotes SNARE-complex assembly by chaperoning SNAP-25 during synaptic activity.
Impact
Südhof et al., Palo Alto, United States. In Nat Cell Biol, 2011
The protein CSPα resides in presynaptic terminals, where it forms a chaperone complex with Hsc70 and SGT.
Structural basis for assembly and activation of the heterotetrameric SAGA histone H2B deubiquitinase module.
Impact
Zheng et al., Heidelberg, Germany. In Cell, 2010
In the "assembly lobe," a long Sgf11 N-terminal helix is clamped onto the Ubp8 ZnF-UBP domain by Sus1.
The HSP90-SGT1 chaperone complex for NLR immune sensors.
Review
Impact
Shirasu, Yokohama, Japan. In Annu Rev Plant Biol, 2008
Such maintenance of NLR-type sensors requires the SGT1-HSP90 pair, a chaperone complex that is structurally and functionally conserved in eukaryotes.
Comment on "A G protein coupled receptor is a plasma membrane receptor for the plant hormone abscisic acid".
Impact
Willard et al., Chapel Hill, United States. In Science, 2007
Liu et al. (Reports, 23 March 2007, p. 1712) reported that the Arabidopsis thaliana gene GCR2 encodes a seven-transmembrane, G protein-coupled receptor for abscisic acid.
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