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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Ring finger protein 123

ubiquitin ligase
The protein encoded by this gene contains a C-terminal RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions, and an N-terminal SPRY domain. This protein displays E3 ubiquitin ligase activity toward the cyclin-dependent kinase inhibitor 1B which is also known as p27 or KIP1. [provided by RefSeq, Feb 2012] (from NCBI)
Top mentioned proteins: Ubiquitin, CAN, V1a, Cullin, SCF
Papers on ubiquitin ligase
Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53.
New
Impact
Zanier et al., Illkirch-Graffenstaden, France. In Nature, Feb 2016
In this process, E6 binds to a short leucine (L)-rich LxxLL consensus sequence within the cellular ubiquitin ligase E6AP.
Antagonistic roles for the ubiquitin ligase Asr1 and the ubiquitin-specific protease Ubp3 in subtelomeric gene silencing.
New
Tansey et al., Nashville, United States. In Proc Natl Acad Sci U S A, Feb 2016
UNASSIGNED: Ubiquitin, and components of the ubiquitin-proteasome system, feature extensively in the regulation of gene transcription.
The RING Finger E3 Ligase SpRing is a Positive Regulator of Salt Stress Signaling in Salt-Tolerant Wild Tomato Species.
New
Hua et al., Beijing, China. In Plant Cell Physiol, Feb 2016
In vitro ubiquitination assay revealed that SpRing is an E3 ubiquitin ligase and the RING finger conserved region is required for its activity.
An ID2-dependent mechanism for VHL inactivation in cancer.
New
Impact
Lasorella et al., New York City, United States. In Nature, Feb 2016
ID2 binds to the VHL ubiquitin ligase complex, displaces VHL-associated Cullin 2, and impairs HIF2α ubiquitylation and degradation.
Adenovirus-mediated downregulation of the ubiquitin ligase RNF8 sensitizes bladder cancer to radiotherapy.
New
Wang et al., Lanzhou, China. In Oncotarget, Feb 2016
UNASSIGNED: The ubiquitin ligase RNF8 promotes the DNA damage response (DDR).
Molecular characterization of Oryza sativa arsenic-induced RING E3 ligase 1 (OsAIR1): Expression patterns, localization, functional interaction, and heterogeneous overexpression.
New
Jang et al., Ch'unch'ŏn, South Korea. In J Plant Physiol, Feb 2016
We attempted to isolate As-responsive Really Interesting New Gene (RING) E3 ubiquitin ligase genes from rice, and we have designated one such gene Oryza sativa arsenic-induced RING E3 ligase 1 (OsAIR1).
Diabetic Cardiomyopathy: Role of the E3 Ubiquitin Ligase.
Review
New
Cai et al., Jilin, China. In Am J Physiol Endocrinol Metab, Feb 2016
UNASSIGNED: Diabetic cardiomyopathy (DCM) is the leading cause of mortality in diabetes.
TRAIP promotes DNA damage response during genome replication and is mutated in primordial dwarfism.
New
Impact
Jackson et al., Köln, Germany. In Nat Genet, Jan 2016
Here we report the identification of mutations in TRAIP, encoding an E3 RING ubiquitin ligase, in patients with microcephalic primordial dwarfism.
A mechanism for the suppression of homologous recombination in G1 cells.
New
Impact
Durocher et al., Toronto, Canada. In Nature, Jan 2016
We found that the BRCA1-interaction site on PALB2 is targeted by an E3 ubiquitin ligase composed of KEAP1, a PALB2-interacting protein, in complex with cullin-3 (CUL3)-RBX1 (ref.
Roquin-a multifunctional regulator of immune homeostasis.
Review
New
Klein et al., Houston, United States. In Genes Immun, Jan 2016
UNASSIGNED: Roquin-1 (Rc3h1) is an E3 ubiquitin ligase originally discovered in a mutational screen for genetic factors contributory to systemic lupus erythematosus-like symptoms in mice.
NFKB1: a Suppressor of Inflammation, Ageing and Cancer.
Review
New
Wilson et al., Newcastle upon Tyne, United Kingdom. In Febs J, Jan 2016
In humans, low KPC1 expression, a ubiquitin ligase required for p105 to p50 processing, was shown to correlate with a reduction in p50 and glioblastoma incidence.
β-Cell Insulin Secretion Requires the Ubiquitin Ligase COP1.
New
Impact
Dixit et al., San Francisco, United States. In Cell, Jan 2016
Here, we show that post-translational regulation of the transcription factors ETV1, ETV4, and ETV5 by the ubiquitin ligase COP1 (also called RFWD2) in β cells is critical for insulin secretion.
Crystal structure and SUMO binding of Slx1-Slx4 complex.
New
Qian et al., Hong Kong, Hong Kong. In Sci Rep, Dec 2015
Structural and sequence analyses indicate Slx1 C-terminal domain is actually an atypical C4HC3-type RING finger which normally possesses E3 ubiquitin ligase activity, but here is absolutely required for Slx1 interaction with Slx4.
The Roles of RNase-L in Antimicrobial Immunity and the Cytoskeleton-Associated Innate Response.
Review
New
Hassel et al., Baltimore, United States. In Int J Mol Sci, Dec 2015
We also describe here the interaction of RNase-L with the E3 ubiquitin ligase and scaffolding protein, ligand of nump protein X (LNX), a regulator of tight junction proteins.
Shigella IpaH Family Effectors as a Versatile Model for Studying Pathogenic Bacteria.
Review
Sasakawa et al., Tokyo, Japan. In Front Cell Infect Microbiol, 2014
One of Shigella T3SS effectors, IpaH family proteins, which have E3 ubiquitin ligase activity and are widely conserved among other bacterial pathogens, are very relevant because they promote bacterial survival by triggering cell death and modulating the host immune responses.
High dimensional endophenotype ranking in the search for major depression risk genes.
GeneRIF
Blangero et al., Hartford, United States. In Biol Psychiatry, 2012
This study deministrated that genome-wide significant quantitative trait locus was localized on chromsome 4p15 exhibiting pleiotropic effects on both the endophenotype (lymphocyte-derived expression levels of the RNF123 gene) and disease risk.
miR-221 and miR-155 regulate human dendritic cell development, apoptosis, and IL-12 production through targeting of p27kip1, KPC1, and SOCS-1.
GeneRIF
Zhou et al., Minneapolis, United States. In Blood, 2011
Dendritic cell apoptosis was at least regulated by miR-221 and miR-155 through targeting the 3'-UTRs of p27kip1 and Kip1 ubiquitination-promoting complex 1 (KPC1), respectively.
Molecular dissection of the interaction between p27 and Kip1 ubiquitylation-promoting complex, the ubiquitin ligase that regulates proteolysis of p27 in G1 phase.
GeneRIF
Nakayama et al., Fukuoka, Japan. In J Biol Chem, 2005
Free p27 is recognized by the amino-terminal region of KPC1, which also associates with KPC2, and p27 is then polyubiquitylated by the carboxy-terminal RING-finger domain of KPC1.
Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1) at G1 phase.
Impact
GeneRIF
Nakayama et al., Fukuoka, Japan. In Nat Cell Biol, 2004
KPC thus probably controls degradation of p27(Kip1) in G1 phase after export of the latter from the nucleus
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