Roquin-a multifunctional regulator of immune homeostasis.
Houston, United States. In Genes Immun, Jan 2016
UNASSIGNED: Roquin-1 (Rc3h1) is an E3 ubiquitin ligase originally discovered in a mutational screen for genetic factors contributory to systemic lupus erythematosus-like symptoms in mice.
β-Cell Insulin Secretion Requires the Ubiquitin Ligase COP1.
San Francisco, United States. In Cell, Jan 2016
Here, we show that post-translational regulation of the transcription factors ETV1, ETV4, and ETV5 by the ubiquitin ligase COP1 (also called RFWD2) in β cells is critical for insulin secretion.
Crystal structure and SUMO binding of Slx1-Slx4 complex.
Hong Kong, Hong Kong. In Sci Rep, Dec 2015
Structural and sequence analyses indicate Slx1 C-terminal domain is actually an atypical C4HC3-type RING finger which normally possesses E3 ubiquitin ligase activity, but here is absolutely required for Slx1 interaction with Slx4.