β-Cell Insulin Secretion Requires the Ubiquitin Ligase COP1.
San Francisco, United States. In Cell, Jan 2016
Here, we show that post-translational regulation of the transcription factors ETV1, ETV4, and ETV5 by the ubiquitin ligase COP1 (also called RFWD2) in β cells is critical for insulin secretion.
Crystal structure and SUMO binding of Slx1-Slx4 complex.
Hong Kong, Hong Kong. In Sci Rep, Dec 2015
Structural and sequence analyses indicate Slx1 C-terminal domain is actually an atypical C4HC3-type RING finger which normally possesses E3 ubiquitin ligase activity, but here is absolutely required for Slx1 interaction with Slx4.
SOCS2: physiological and pathological functions.
Luxembourg, Luxembourg. In Front Biosci (elite Ed), Dec 2015
SOCS proteins are able to act as substrate-recruiting component of E3-ubiquitin ligase complexes and target interacting proteins for degradation.