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UbiA prenyltransferase domain containing 1

UBIAD1, TERE1, UbiA prenyltransferase domain-containing protein 1
This gene encodes a protein thought to be involved in cholesterol and phospholipid metabolism. Mutations in this gene are associated with Schnyder crystalline corneal dystrophy. [provided by RefSeq, Oct 2008] (from NCBI)
Top mentioned proteins: CAN, V1a, ACID, HOT, MAPK
Papers on UBIAD1
Putative effectors for prognosis in lung adenocarcinoma are ethnic and gender specific.
Yeang et al., Taipei, Taiwan. In Oncotarget, Sep 2015
Modules 1 (cis-acting effects with chromosome 7 CNV) and 3 (DNA methylations of UBIAD1 and VAV1) possessed significantly negative associations with survival times among two East Asian patient cohorts.
YY1 positively regulates human UBIAD1 expression.
Okano et al., Kōbe, Japan. In Biochem Biophys Res Commun, Jun 2015
UbiA prenyltransferase domain containing 1 (UBIAD1 or TERE1) is the menaquinone-4 biosynthetic enzyme.
Heixuedian (heix), a potential melanotic tumor suppressor gene, exhibits specific spatial and temporal expression pattern during Drosophila hematopoiesis.
Hong et al., Wuhan, China. In Dev Biol, Mar 2015
The Drosophila heixuedian (heix) is the ortholog of human UBIAD1 gene (a.k.a TERE1).
The prenyltransferase UBIAD1 is the target of geranylgeraniol in degradation of HMG CoA reductase.
DeBose-Boyd et al., Dallas, United States. In Elife, 2014
SCD-associated mutations have been identified in the gene encoding UBIAD1, a prenyltransferase that synthesizes vitamin K2.
Functional characterization of the vitamin K2 biosynthetic enzyme UBIAD1.
Okano et al., Kōbe, Japan. In Plos One, 2014
UbiA prenyltransferase domain-containing protein 1 (UBIAD1) plays a significant role in vitamin K2 (MK-4) synthesis.
Structure of a membrane-embedded prenyltransferase homologous to UBIAD1.
Zhou et al., College Station, United States. In Plos Biol, 2014
In humans, missense mutations to the protein UbiA prenyltransferase domain-containing 1 (UBIAD1) are responsible for Schnyder crystalline corneal dystrophy, which is a genetic disease that causes blindness.
Phenotype-genotype correlation in patients with Schnyder corneal dystrophy.
Puzzolo et al., Katowice, Poland. In Cornea, 2014
PURPOSE: The aim of this study was to analyze the corneal morphology features and define mutations in the UbiA prenyltransferase domain-containing 1 (UBIAD1) gene in patients with Schnyder corneal dystrophy from a Polish population.
Recent trends in the metabolism and cell biology of vitamin K with special reference to vitamin K cycling and MK-4 biosynthesis.
Newman et al., London, United Kingdom. In J Lipid Res, 2014
In parallel, a novel human enzyme that participates in the cellular conversion of phylloquinone to menaquinone (MK)-4 was identified as UbiA prenyltransferase-containing domain 1 (UBIAD1).
Vitamin K2 biosynthetic enzyme, UBIAD1 is essential for embryonic development of mice.
Okano et al., Kōbe, Japan. In Plos One, 2013
UbiA prenyltransferase domain containing 1 (UBIAD1) is a novel vitamin K2 biosynthetic enzyme screened and identified from the human genome database.
Ubiad1 is an antioxidant enzyme that regulates eNOS activity by CoQ10 synthesis.
Santoro et al., Torino, Italy. In Cell, 2013
Here, we identified a gene with important antioxidant features by analyzing a null allele of zebrafish ubiad1, called barolo (bar).
[Biological significance and metabolic activation of vitamin K].
Nakagawa, Kōbe, Japan. In Yakugaku Zasshi, 2012
We found UbiA prenyltransferase domain containing 1 (UBIAD1), a human homologue of Escherichia coli prenyltransferase menA.
Vitamin K2 is a mitochondrial electron carrier that rescues pink1 deficiency.
Verstreken et al., Leuven, Belgium. In Science, 2012
Human UBIAD1 localizes to mitochondria and converts vitamin K(1) to vitamin K(2).
The bladder tumor suppressor protein TERE1 (UBIAD1) modulates cell cholesterol: implications for tumor progression.
Malkowicz et al., Philadelphia, United States. In Dna Cell Biol, 2011
the inhibitory effects of ectopic TERE1 expression on tumorigenic growth
A mutation in the UBIAD1 gene in a Han Chinese family with Schnyder corneal dystrophy.
Han et al., Harbin, China. In Mol Vis, 2010
The nonsynonymous mutation, N102S, in the UBIAD1 gene has been detected in in a four-generation Chinese family with Schnyder corneal dystrophy (SCD).
Differential diagnosis of Schnyder corneal dystrophy.
Khemichian et al., New Orleans, United States. In Dev Ophthalmol, 2010
SCD is inherited as an autosomal dominant trait with high penetrance and has been mapped to the UBIAD1 gene on chromosome 1p36.3.
Identification of UBIAD1 as a novel human menaquinone-4 biosynthetic enzyme.
Okano et al., Kōbe, Japan. In Nature, 2010
results show that UBIAD1 is a human MK-4 biosynthetic enzyme; this identification will permit more effective decisions to be made about vitamin K intake and bone health
Newly reported p.Asp240Asn mutation in UBIAD1 suggests central discoid corneal dystrophy is a variant of Schnyder corneal dystrophy.
Aldave et al., Detroit, United States. In Cornea, 2010
Our newly reported UBIAD1 mutation suggests that central discoid corneal dystrophy (CDCD) is actually a variant of schnyder corneal dystrophy.
UBIAD1 mutation alters a mitochondrial prenyltransferase to cause Schnyder corneal dystrophy.
Weiss et al., Frederick, United States. In Plos One, 2009
Mitochondrial UBIAD1 protein appears to have a highly conserved function that, at least in humans, is involved in cholesterol metabolism in a novel manner.
Corneal dystrophies.
Klintworth, Durham, United States. In Orphanet J Rare Dis, 2008
Different corneal dystrophies are caused by mutations in the CHST6, KRT3, KRT12, PIP5K3, SLC4A11, TACSTD2, TGFBI, and UBIAD1 genes.
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