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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Ubiquitin specific peptidase 12

UBH1, USP12, ubiquitin hydrolyzing enzyme 1
Top mentioned proteins: Ubiquitin, USP46, ACID, Inactive, FATE
Papers on UBH1
Identification of Ten Additional Susceptibility Loci for Ulcerative Colitis Through Immunochip Analysis in Koreans.
New
Song et al., Seoul, South Korea. In Inflamm Bowel Dis, Jan 2016
RESULTS: We confirmed the associations of 10 known UC risk loci in Koreans: rs76418789 in IL23R (combined P = 1.25 × 10), rs4728142 in IRF5 (combined P = 3.17 × 10), rs1830610 near JAK2 (combined P = 2.28 × 10), rs1555791 near TNFRSF14 (combined P = 1.62 × 10), rs880790 between IL10-IL19 (combined P = 3.73 × 10), rs10185424 between IL1R2-IL1R1 (combined P = 1.54 × 10), rs6478108 in TNFSF15 (combined P = 9.28 × 10), rs861857 between UBE2L3-YDJC (combined P = 3.05 × 10), rs1801274 in FCGR2A (discovery P = 1.54 × 10), and rs17085007 between GPR12-USP12 (discovery P = 3.64 × 10).
Identification of focally amplified lineage-specific super-enhancers in human epithelial cancers.
New
Impact
Meyerson et al., Boston, United States. In Nat Genet, Jan 2016
Copy number gains of noncoding regions harboring super-enhancers near KLF5, USP12, PARD6B and MYC are associated with overexpression of these cancer-related genes.
USP12 regulates cell cycle progression by involving c-Myc, cyclin D2 and BMI-1.
New
Tian et al., Shijiazhuang, China. In Gene, Jan 2016
UNASSIGNED: Ubiquitin-specific protease 12 (USP12) plays a significant role in tumor cell apoptosis and cell cycle progression.
Structural Insights into WD-Repeat 48 Activation of Ubiquitin-Specific Protease 46.
New
Harris et al., San Francisco, United States. In Structure, Dec 2015
The WD-repeat protein WDR48 (USP1-associated factor UAF-1) stimulates activity of ubiquitin-specific proteases USP1, USP12, and USP46.
Artificial Recruitment of UAF1-USP Complexes by a PHLPP1-E1 Chimeric Helicase Enhances Human Papillomavirus DNA Replication.
New
Archambault et al., Montréal, Canada. In J Virol, Jun 2015
UNLABELLED: The E1 helicase from anogenital human papillomavirus (HPV) types interacts with the cellular WD repeat-containing protein UAF1 in complex with the deubiquitinating enzyme USP1, USP12, or USP46.
The EBNA3 family of Epstein-Barr virus nuclear proteins associates with the USP46/USP12 deubiquitination complexes to regulate lymphoblastoid cell line growth.
New
Johannsen et al., Cambridge, United States. In Plos Pathog, Apr 2015
Mass-spectrometry revealed that the EBNA3A and EBNA3B complexes also contained the deubquitylation complex consisting of WDR48, WDR20, and USP46 (or its paralog USP12) and that EBNA3C complexes contained WDR48.
E1-mediated recruitment of a UAF1-USP deubiquitinase complex facilitates human papillomavirus DNA replication.
Archambault et al., Montréal, Canada. In J Virol, 2014
In this study, we determined by affinity purification of UAF1 that it interacts with three deubiquitinating enzymes in C33A cervical carcinoma cells: USP1, a nuclear protein, and the two cytoplasmic enzymes USP12 and USP46.
WD repeat protein WDR48 in complex with deubiquitinase USP12 suppresses Akt-dependent cell survival signaling by stabilizing PH domain leucine-rich repeat protein phosphatase 1 (PHLPP1).
Maddika et al., Hyderābād, India. In J Biol Chem, 2013
In this study, by utilizing the tandem affinity purification approach we have identified WDR48 and USP12 as novel PHLPP1-associated proteins.
The ubiquitin-specific protease 12 (USP12) is a negative regulator of notch signaling acting on notch receptor trafficking toward degradation.
GeneRIF
Brou et al., Paris, France. In J Biol Chem, 2012
The ubiquitin-specific protease 12 (USP12) is a negative regulator of notch signaling acting on notch receptor trafficking toward degradation.
Regulation of histone H2A and H2B deubiquitination and Xenopus development by USP12 and USP46.
Wang et al., Birmingham, United States. In J Biol Chem, 2011
Here, we identified USP12 and USP46 as histone H2A and H2B deubiquitinases that regulate Xenopus development.
WDR20 regulates activity of the USP12 x UAF1 deubiquitinating enzyme complex.
GeneRIF
D'Andrea et al., Boston, United States. In J Biol Chem, 2010
WDR20 serves as a stimulatory subunit for preserving and regulating the activity of the subset of the UAF1 x USP12 complexes
UAF1 is a subunit of multiple deubiquitinating enzyme complexes.
GeneRIF
D'Andrea et al., Boston, United States. In J Biol Chem, 2009
two novel multisubunit deubiquitinating enzyme complexes containing USP12 and USP46, respectively. Both complexes contain the UAF1 protein as a bona fide subunit. Interestingly, UAF1
Molecular cloning and complete cDNA sequence of UBH1 in mouse testis.
GeneRIF
Choi et al., Seoul, South Korea. In Dna Seq, 2002
Product has deubiquitinating enzyme activity and sequence analysis showed 98.3% amino acid identity with human UBH1.
Carbon catabolite repression in Aspergillus nidulans involves deubiquitination.
Kelly et al., Adelaide, Australia. In Mol Microbiol, 2001
We show here that the creB gene involved in carbon catabolite repression in Aspergillus nidulans encodes a functional member of the novel subfamily of the ubp family defined by the human homologue UBH1, thus implicating ubiquitination in the process of carbon catabolite repression.
Sequencing, tissue distribution and chromosomal assignment of a novel ubiquitin-specific protease USP23.
Southan et al., King of Prussia, United States. In Biochim Biophys Acta, 2000
Human tissue Northern blots revealed USP23 to be ubiquitously expressed, whereas USP12, its closest human paralogue, displayed a more restricted expression pattern.
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