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Upstream binding transcription factor, RNA polymerase I

UBF, UBF1, transcription factor UBF, NOR-90
This gene encodes a member of the HMG-box DNA-binding protein family. The encoded protein plays a critical role in ribosomal RNA transcription as a key component of the pre-initiation complex, mediating the recruitment of RNA polymerase I to rDNA promoter regions. The encoded protein may also play important roles in chromatin remodeling and pre-rRNA processing, and its activity is regulated by both phosphorylation and acetylation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the short arm of chromosomes 3, 11 and X and the long arm of chromosome 11. [provided by RefSeq, Aug 2011] (from NCBI)
Top mentioned proteins: POLYMERASE, CAN, HAD, Histone, ACID
Papers using UBF antibodies
Towards many colors in FISH on 3D-preserved interphase nuclei.
Supplier
Akhtar Asifa, In PLoS Genetics, 2005
... UBF and laminA/C protein levels were monitored with the sc-9131 and sc-20681 antibodies (Santa Cruz Biotechnology), respectively.
Nucleolar protein B23/nucleophosmin regulates the vertebrate SUMO pathway through SENP3 and SENP5 proteases
Supplier
Dasso Mary et al., In The Journal of Cell Biology, 2003
... Mouse monoclonal anti-B23/nucleophosmin and anti-UBF antibodies were from Santa Cruz Biotechnology, Inc ...
Systematic functional analysis of the Caenorhabditis elegans genome using RNAi.
Supplier
Burns Jorge Sans, In PLoS ONE, 2002
... Mouse anti-GFP (Covance Research Products) anti-myc (myc-Tag 9B11) (DSHB), anti-B23/Nucleophosmin (AB10530; Abcam) and anti-UBF (H00007343-M01), goat anti-PICT-1 (C-20, Santa Cruz), and rabbit anti-Fibrillarin (AB5821; Abcam) were used with either ...
Papers on UBF
Impaired Ribosome Biogenesis and Skeletal Muscle Growth in a Murine Model of Inflammatory Bowel Disease.
New
Cameron-Smith et al., Auckland, New Zealand. In Inflamm Bowel Dis, Feb 2016
The abundance of growth-related proteins (p70S6K and upstream binding factor, UBF) was decreased in Il10 mice.
Acute resistance exercise activates rapamycin-sensitive and -insensitive mechanisms that control translational activity and capacity in skeletal muscle.
New
Baar et al., Davis, United States. In J Physiol, Feb 2016
REx also altered pathways that regulate protein homeostasis and mRNA translation in a manner that was both rapamycin-sensitive (proteasome activity; phosphorylation of S6K1 and rpS6) and rapamycin-insensitive (phosphorylation of eEF2, ERK1/2 and UBF; gene expression of the myostatin target Mighty as well as c-Myc and its targets involved in ribosome biogenesis).
A-kinase anchoring protein AKAP95 is a novel regulator of ribosomal RNA synthesis.
New
Brede et al., Trondheim, Norway. In Febs J, Jan 2016
We show that AKAP95 co-localizes with the nucleolar Upstream Binding Factor (UBF), an essential rRNA transcription factor.
Analysis of histone modifications at human ribosomal DNA in liver cancer cell.
Yu et al., Xi'an, China. In Sci Rep, 2014
Furtherly, we studied whether UBF could affect histone modification markers and CTCF at rDNA in human liver cancer cell.
Altered machinery of protein synthesis is region- and stage-dependent and is associated with α-synuclein oligomers in Parkinson's disease.
Ferrer et al., Barcelona, Spain. In Acta Neuropathol Commun, 2014
RESULTS: Reduced mRNA expression of nucleolar proteins nucleolin (NCL), nucleophosmin (NPM1), nucleoplasmin 3 (NPM3) and upstream binding transcription factor (UBF), decreased NPM1 but not NPM3 nucleolar protein immunostaining in remaining neurons; diminished 18S rRNA, 28S rRNA; reduced expression of several mRNAs encoding ribosomal protein (RP) subunits; and altered protein levels of initiation factor eIF3 and elongation factor eEF2 of protein synthesis was found in the substantia nigra in PD along with disease progression.
Nucleolar dysfunction in Huntington's disease.
Review
Ryu et al., Boston, United States. In Biochim Biophys Acta, 2014
In this review, we discuss about how post-translational modifications of upstream binding factor (UBF) are affected by histone acetyltransferase and histone methyltransferase and involved in the transcriptional regulation of rDNA in HD.
Gap junction regulation of vascular tone: implications of modulatory intercellular communication during gestation.
Review
Magness et al., Madison, United States. In Adv Exp Med Biol, 2013
Pregnancy requires highly developed cell-to-cell coupling, which is affected partly through the formation of intercellular GJs by Cx43, a gap junction protein, within adjacent cell membranes to help facilitate the increase of uterine blood flow (UBF) in order to ensure adequate perfusion for nutrient and oxygen delivery to the placenta and thus the fetus.
Diagnostic accuracy and predictive value of extended autoantibody profile in systemic sclerosis.
Review
Bizzaro et al., Pordenone, Italy. In Autoimmun Rev, 2012
Even if other autoantibodies, such as anti-fibrillarin (AFA), anti-RNA polymerase III (RNAP III), anti-PMScl, anti-Th/To, and anti-hUF/NOR-90, are almost specific for SSc, until recently they were not routinely looked for, since the techniques for their identification were not suitable for routine use.
Biomarkers of brain damage in preterm infants.
Review
Gazzolo et al., Genova, Italy. In J Matern Fetal Neonatal Med, 2012
MATERIALS AND METHODS: The concept of Unconventional Biological Fluid (UBF: urine and saliva) is becoming even stronger and regards the assessment in non-invasive biological fluids of biochemical markers involved in the cascade of events leading to brain damage.
Dysregulation of upstream binding factor-1 acetylation at K352 is linked to impaired ribosomal DNA transcription in Huntington's disease.
GeneRIF
Ryu et al., Boston, United States. In Cell Death Differ, 2011
UBF1 mutation (K352A, K352Q, and K352R) decreased rDNA transcriptional activity.
hALP, a novel transcriptional U three protein (t-UTP), activates RNA polymerase I transcription by binding and acetylating the upstream binding factor (UBF).
GeneRIF
Ke et al., Beijing, China. In J Biol Chem, 2011
hALP binds the upstream binding factor (UBF) in vivo and in vitro
Ribosomal biogenesis induction by high glucose requires activation of upstream binding factor in kidney glomerular epithelial cells.
GeneRIF
Kasinath et al., San Antonio, United States. In Am J Physiol Renal Physiol, 2011
augmented ribosome biogenesis occurs in UBF-dependent manner during increased protein synthesis induced by high glucose in glomerular epithelial cells that correlates with UBF activation and renal hypertrophy in rodents with type 1 and type 2 diabetes.
Regulation of nucleolar chromatin by B23/nucleophosmin jointly depends upon its RNA binding activity and transcription factor UBF.
GeneRIF
Okuwaki et al., Tsukuba, Japan. In Mol Cell Biol, 2010
depletion of upstream binding factor (UBF; an rRNA transcription factor) decreased the chromatin binding affinity of B23, which in turn led to an increase in histone density at the r-chromatin
Treacle recruits RNA polymerase I complex to the nucleolus that is independent of UBF.
GeneRIF
Yeh et al., Taipei, Taiwan. In Biochem Biophys Res Commun, 2009
central repeated domain of treacle binds with RNA polymerase I, while that the treacle C-terminus is involved in rDNA promoter recognition and UBF recruitment.
The role of UBF in regulating the structure and dynamics of transcriptionally active rDNA chromatin.
Review
Hannan et al., Melbourne, Australia. In Epigenetics, 2009
In this review we discuss the role of the cytoarchitectural transcription factor UBF in determining and maintaining the active (euchromatic) state of rDNA in mammals.
Mitotic occupancy and lineage-specific transcriptional control of rRNA genes by Runx2.
Impact
Stein et al., Worcester, United States. In Nature, 2007
These Runx2 chromosomal foci are associated with open chromatin, co-localize with the RNA Pol I transcription factor UBF1, and undergo transition into nucleoli at sites of rRNA synthesis during interphase.
Coactivator and promoter-selective properties of RNA polymerase I TAFs.
Impact
Tjian et al., Berkeley, United States. In Science, 1996
Human ribosomal RNA synthesis by RNA polymerase I requires the activator UBF and the promoter selectivity factor SL1, which consists of the TATA binding protein (TBP) and three associated subunits, TAFI110, TAFI63, and TAFI48.
Activity of RNA polymerase I transcription factor UBF blocked by Rb gene product.
Impact
Rothblum et al., United States. In Nature, 1995
Here we report that (1) there is an accumulation of Rb protein in the nucleoli of differentiated U937 cells which correlates with inhibition of rDNA transcription; (2) addition of Rb to an in vitro transcription system inhibits transcription by RNA polymerase I; (3) this inhibition requires a functional Rb pocket; and (4) Rb specifically inhibits the activity of the RNA polymerase I transcription factor UBF (upstream binding factor) in vitro.
Short-range DNA looping by the Xenopus HMG-box transcription factor, xUBF.
Impact
Moss et al., Calgary, Canada. In Science, 1994
Xenopus UBF (xUBF) interacts with DNA by way of multiple HMG-box domains.
Human rRNA transcription is modulated by the coordinate binding of two factors to an upstream control element.
Impact
Tjian et al., In Cell, 1986
DNAase footprinting revealed that although SL1 alone does not bind specifically to rRNA promoter sequences, a second factor, UBF1, recruits SL1 to the template and directs binding to an extended region encompassing sequences in the UCE.
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