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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Ubiquitin-like modifier activating enzyme 1

UBE1, ubiquitin-activating enzyme E1, UBA1, AIST
The protein encoded by this gene catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation. This gene complements an X-linked mouse temperature-sensitive defect in DNA synthesis, and thus may function in DNA repair. It is part of a gene cluster on chromosome Xp11.23. Alternatively spliced transcript variants that encode the same protein have been described. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Ubiquitin, CAN, ACID, STEP, HAD
Papers using UBE1 antibodies
The error-free component of the RAD6/RAD18 DNA damage tolerance pathway of budding yeast employs sister-strand recombination
Supplier
Ulrich Helle D et al., In The EMBO Journal, 2004
... Uba1 (E1) was purchased from BioMol and ubiquitin and its ...
Papers on UBE1
Ubiquitination is absolutely required for the degradation of hypoxia-inducible factor - 1 alpha protein in hypoxic conditions.
New
Shi et al., Qingdao, China. In Biochem Biophys Res Commun, Feb 2016
Further inhibition of E1 at 39.5(o) by siRNA, or E1 inhibitor Ube1-41 completely blocked HIF-1α degradation.
Type I IFN induces protein ISGylation to enhance cytokine expression and augments colonic inflammation.
New
Zhang et al., Budapest, Hungary. In Proc Natl Acad Sci U S A, Dec 2015
Thus our studies reveal a regulatory role for protein ISGylation in colonic inflammation and its related malignant progression, indicating that targeting ubiquitin-activating enzyme E1 homolog has therapeutic potential in treating inflammatory diseases.
PUGNAc induces protein ubiquitination in C2C12 myotube cells.
New
Baek et al., Taegu, South Korea. In Cell Biochem Funct, Dec 2015
Upregulation of proteins, including ubiquitin-activating enzyme E1, proteasome subunit 20S, cullin-associated NEDD8-dissociated protein 1, ezrin, and downregulation of the protein nucleoside diphosphate kinase B, were confirmed by western blot analysis.
Comparative Proteomic Analysis of Wild-Type and SAP Domain Mutant Foot-and-Mouth Disease Virus-Infected Porcine Cells Identifies the Ubiquitin-Activating Enzyme UBE1 Required for Virus Replication.
New
Zheng et al., Lanzhou, China. In J Proteome Res, Nov 2015
One of the identified proteins UBE1 was further analyzed and displayed a novel role for the SAP domain of L(pro).
UBA1: At the Crossroads of Ubiquitin Homeostasis and Neurodegeneration.
Review
New
Gillingwater et al., Edinburgh, United Kingdom. In Trends Mol Med, Oct 2015
Ubiquitin-like modifier activating enzyme 1 (UBA1), the E1 ubiquitin-activating enzyme, sits at the apex of the ubiquitin cascade and represents an important regulator of cellular protein homeostasis.
X-linked spinal muscular atrophy (SMAX2) caused by de novo c.1731C>T substitution in the UBA1 gene.
New
Kostera-Pruszczyk et al., Warsaw, Poland. In Neuromuscul Disord, Aug 2015
Infantile X-linked spinal muscular atrophy (SMAX2) is a rare form of spinal muscular atrophy manifesting as severe hypotonia, areflexia, arthrogryposis, facial weakness and cryptorchidism, and frequently accompanied by bone fractures.
High-Pressure NMR Spectroscopy Reveals Functional Sub-states of Ubiquitin and Ubiquitin-Like Proteins.
Review
Kitahara, Kusatsu, Japan. In Subcell Biochem, 2014
The N2 state of ubiquitin is closely similar to the conformation of the protein bound to the ubiquitin-activating enzyme E1.
New insights to the ubiquitin-proteasome pathway (UPP) mechanism during spermatogenesis.
Review
Yang et al., Hangzhou, China. In Mol Biol Rep, 2013
UPP contains various indispensable components: ubiquitin, ubiquitin-activating enzyme E1, ubiquitin-conjugating enzyme E2, ubiquitin ligase enzyme E3 and proteasomes.
Targeting the ubiquitin E1 as a novel anti-cancer strategy.
Review
Schimmer et al., Toronto, Canada. In Curr Pharm Des, 2012
In contrast, the biological effects and potential therapeutic utility of inhibiting the ubiquitination cascade and the initiating enzyme UBA1 are less well understood.
Neddylation dysfunction in Alzheimer's disease.
Review
Liu et al., Little Rock, United States. In J Cell Mol Med, 2012
Central to the neddylation pathway is the amyloid precursor protein (APP)-binding protein APP-BP1, which together with Uba3, plays an analogous role to the ubiquitin-activating enzyme E1 in nedd8 activation.
Ubiquitin-activating enzyme UBA1 is required for cellular response to DNA damage.
GeneRIF
Bartek et al., Praha, Czech Republic. In Cell Cycle, 2012
UBA1 knockdown impairs formation of ubiquitin conjugates at DNA double-strand breaks.
The ubiquitin E1 enzyme Ube1 mediates NEDD8 activation under diverse stress conditions.
GeneRIF
Xirodimas et al., Montpellier, France. In Cell Cycle, 2012
Decrease in free ubiquitin levels under stress allows NEDD8 to be conjugated through Ube1.
Largazole and its derivatives selectively inhibit ubiquitin activating enzyme (e1).
GeneRIF
Liu et al., Boulder, United States. In Plos One, 2011
Data show that largazole and ester/keto analogs inhibit ubiquitin E1 activation.
[The quantitative analysis of Ub and UbE1 in focus of traumatic epilepsy].
GeneRIF
Jing et al., Guangzhou, China. In Fa Yi Xue Za Zhi, 2010
Ubiquitin and UBE1 are upregulated in tic epilepsy.
Ziram causes dopaminergic cell damage by inhibiting E1 ligase of the proteasome.
GeneRIF
Bronstein et al., Los Angeles, United States. In J Biol Chem, 2009
E1 ligase of the proteasome is inhibitd by ziram and has a role in preventing dopaminergic cell damage
Dual E1 activation systems for ubiquitin differentially regulate E2 enzyme charging.
Impact
GeneRIF
Harper et al., Boston, United States. In Nature, 2007
Human Uba6 and Ube1 have distinct preferences for E2 charging in vitro, and their specificity depends in part on their C-terminal ubiquitin-fold domains, which recruit E2s
Gigaxonin-controlled degradation of MAP1B light chain is critical to neuronal survival.
Impact
Yang et al., Stanford, United States. In Nature, 2005
We present evidence that gigaxonin binds to the ubiquitin-activating enzyme E1 through its amino-terminal BTB domain, while the carboxy-terminal kelch repeat domain interacts directly with the light chain (LC) of microtubule-associated protein 1B (MAP1B).
SIR1, an upstream component in auxin signaling identified by chemical genetics.
Impact
Chory et al., San Diego, United States. In Science, 2003
SIR1 is predicted to encode a protein composed of a ubiquitin-activating enzyme E1-like domain and a Rhodanese-like domain homologous to that of prolyl isomerase.
Structural genomics of membrane proteins.
Impact
Nomura et al., Tokyo, Japan. In Acc Chem Res, 2003
A program on the structural genomics of membrane proteins has started at the BIRC, AIST, involving other academic institutions and industrial companies.
The ubiquitin-related protein RUB1 and auxin response in Arabidopsis.
Impact
Estelle et al., Bloomington, United States. In Science, 1998
The AXR1 (auxin-resistant) protein, which has features of the ubiquitin-activating enzyme E1, is required for normal response to the plant hormone auxin in Arabidopsis thaliana.
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