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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Ubiquitin-conjugating enzyme E2L 6

UbcH8, Ubiquitin-Protein Ligase, UBE2E2
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is highly similar in primary structure to the enzyme encoded by the UBE2L3 gene. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2011] (from NCBI)
Top mentioned proteins: Ubiquitin, CAN, UBE3A, V1a, Nedd4
Papers using UbcH8 antibodies
Ubiquitin charging of human class III ubiquitin-conjugating enzymes triggers their nuclear import
Supplier
Macara Ian G. et al., In The Journal of Cell Biology, 1998
... UbcH7, UbcH6, and UBE2E2 were all cloned from a human brain–derived cDNA library (CLONTECH Laboratories, Inc.) using primers ...
Papers on UbcH8
Pathogen-associated molecular patterns activate expression of genes involved in cell proliferation, immunity and detoxification in the amebocyte-producing organ of the snail Biomphalaria glabrata.
New
Sullivan et al., Albuquerque, United States. In Dev Comp Immunol, Mar 2016
In addition to stimulating genes involved in cell proliferation, the injected substances, especially LPS, also induced expression of a number of immune-related genes including arginase, peptidoglycan recognition protein short form, tumor necrosis factor receptor, ficolin, calmodulin, bacterial permeability increasing proteins and E3 ubiquitin-protein ligase.
Allergy-Protective Arabinogalactan Modulates Human Dendritic Cells via C-Type Lectins and Inhibition of NF-κB.
New
Bufe et al., Bochum, Germany. In J Immunol, Feb 2016
Stimulation of these receptors with AG simultaneously with TLR4 stimulation with LPS increased the expression of the E3 ubiquitin-protein ligase tripartite motif -: containing protein 21 and decreased the phosphorylation of NF-κB p65 in DCs.
An Essential Role of Nedd4-2 in the Ubiquitination, Expression, and Function of Organic Anion Transporter-3.
New
You et al., United States. In Mol Pharm, Jan 2016
In the current study, we established that PKC-induced inhibition of OAT3 transport activity occurred through an enhanced OAT3 ubiquitination, a process catalyzed by an E3 ubiquitin-protein ligase Nedd4-2 (neural precursor cell expressed, developmentally downregulated 4-2).
Utilisation of antibody microarrays for the selection of specific and informative antibodies from recombinant library binders of unknown quality.
New
Hoheisel et al., Heidelberg, Germany. In N Biotechnol, Jan 2016
We observed significant variation in the expression of the E3 ubiquitin-protein ligase (CHFR) as well as the glutamate receptor interacting protein 2 (GRIP2), for example, always with more than one of the scFvs binding to these targets.
Ubiquitin phosphorylation in Parkinson's disease: Implications for pathogenesis and treatment.
Review
New
Li et al., Atlanta, United States. In Transl Neurodegener, Dec 2015
The identification of mutations in mitochondrial serine/threonine kinase PINK1 or E3 ubiquitin-protein ligase parkin as the cause of autosomal recessive PD opens up new avenues for uncovering neuroprotective pathways and PD pathogenic mechanisms.
Tourniquet-induced ischaemia during total knee arthroplasty results in higher proteolytic activities within vastus medialis cells: a randomized clinical trial.
New
Roehl et al., Mannheim, Germany. In Knee Surg Sports Traumatol Arthrosc, Dec 2015
Therefore, the purpose of the present study was to quantify the acute effects of the tourniquet application during TKA on the (1) concentrations of free/conjugated ubiquitin, (2) total ubiquitin-protein ligase activity, (3) proteasome-dependent and (4) proteasome-independent peptidase activities in the cells of vastus medialis.
Angelman Syndrome: A Review Highlighting Musculoskeletal and Anatomical Aberrations.
Review
New
Kim et al., Saskatoon, Canada. In Clin Anat, Nov 2015
The cause is a known abnormality involving the maternal inherited ubiquitin-protein ligase (UBE3A) gene.
The Keap1/Nrf2 pathway in health and disease: from the bench to the clinic.
Review
New
Hayes et al., Dundee, United Kingdom. In Biochem Soc Trans, Sep 2015
Regulation of Nrf2 is complex and although much attention has focussed on its repression by Kelch-like ECH-associated protein-1 (Keap1), recently it has become increasingly apparent that it is also controlled by cross-talk with other signalling pathways including the glycogen synthase kinase-3 (GSK-3)-β-transducin repeat-containing protein (β-TrCP) axis, ERAD (endoplasmic reticulum-associated degradation)-associated E3 ubiquitin-protein ligase (Hrd1, also called synoviolin), nuclear factor-kappa B (NF-κB), Notch and AMP kinase.
Molecular mechanisms of Nrf2 regulation and how these influence chemical modulation for disease intervention.
Review
New
Zhang et al., Tucson, United States. In Biochem Soc Trans, Sep 2015
Recently, both beta-transducin repeat-containing E3 ubiquitin protein ligase (β-TrCP) and E3 ubiquitin-protein ligase synoviolin (Hrd1) have been identified as novel E3 ubiquitin ligases that negatively regulate Nrf2 through Keap1-independent mechanisms.
NEDD4-2 and salt-sensitive hypertension.
Review
New
Staub et al., Lausanne, Switzerland. In Curr Opin Nephrol Hypertens, Mar 2015
PURPOSE OF REVIEW: NEDD4-2 is an ubiquitin-protein ligase that was originally identified as an interactor of the epithelial Na+ channel (ENaC); this interaction is defective in Liddle's syndrome, causing elevated ENaC activity and salt-sensitive hypertension.
Selective ubiquitylation of p21 and Cdt1 by UBCH8 and UBE2G ubiquitin-conjugating enzymes via the CRL4Cdt2 ubiquitin ligase complex.
GeneRIF
Dutta et al., Charlottesville, United States. In Mol Cell Biol, 2011
study reports that UBCH8 and UBE2G1 and UBE2G2 cooperate with CRL4Cdt2 in promoting the polyubiquitylation and subsequent degradation of p21 and Cdt1, respectively
A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B.
Impact
GeneRIF
Kadowaki et al., Tokyo, Japan. In Nat Genet, 2010
Single nucleotide polymorphism in UBE2E2 is associated with type 2 diabetes.
Ubiquitin conjugase UBCH8 targets active FMS-like tyrosine kinase 3 for proteasomal degradation.
GeneRIF
Krämer et al., Jena, Germany. In Leukemia, 2010
gain and loss-of-function approaches show that UBCH8 and the ubiquitin-ligase SIAH1 physically interact with and target FLT3-ITD for proteasomal degradation
The structure of the UbcH8-ubiquitin complex shows a unique ubiquitin interaction site.
GeneRIF
Shaw et al., London, Canada. In Biochemistry, 2010
The structure of UbcH8 does not undergo a significant conformational change upon forming a complex with ubiquitin.
Identification of a novel antibody associated with autoimmune pancreatitis.
Impact
Puccetti et al., Verona, Italy. In N Engl J Med, 2009
The peptide showed homology with an amino acid sequence of plasminogen-binding protein (PBP) of Helicobacter pylori and with ubiquitin-protein ligase E3 component n-recognin 2 (UBR2), an enzyme highly expressed in acinar cells of the pancreas.
The basis for selective E1-E2 interactions in the ISG15 conjugation system.
GeneRIF
Huibregtse et al., Austin, United States. In J Biol Chem, 2008
Ube1L was required for transfer of ISG15 to UbcH8 and for binding of Ube1L to UbcH8
DeTEKting ubiquitination of APC/C substrates.
Impact
Wilkinson et al., New Orleans, United States. In Cell, 2008
The APC/C ubiquitin-protein ligase targets proteins by appending polyubiquitin degradation signals that are subsequently recognized by the 26S proteasome.
Sequential E2s drive polyubiquitin chain assembly on APC targets.
Impact
Morgan et al., San Francisco, United States. In Cell, 2007
The anaphase-promoting complex (APC), or cyclosome, is an E3 ubiquitin-protein ligase that collaborates with E2 ubiquitin-conjugating enzymes to assemble polyubiquitin chains on proteins important for cell-cycle progression.
Degradation-mediated protein quality control in the nucleus.
Impact
Gottschling et al., Seattle, United States. In Cell, 2005
It is defined by San1p, a ubiquitin-protein ligase that, in conjunction with the ubiquitin-conjugating enzymes Cdc34p and Ubc1p, targets four distinct mutant nuclear proteins for ubiquitination and destruction by the proteasome.
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