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Ubiquitin-conjugating enzyme E2C

UbcH10, UBE2C, ubiquitin-conjugating enzyme E2C
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for the destruction of mitotic cyclins and for cell cycle progression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009] (from NCBI)
Papers using UbcH10 antibodies
Cdc20: a WD40 activator for a cell cycle degradation machine
van Deursen Jan M. et al., In The Journal of Cell Biology, 2006
... UbcH10 transgenic mice and DMBA treatment ...
Papers on UbcH10
Dominant negative Ubiquitin-conjugating enzyme E2C sensitizes cervical cancer cells to radiation.
Rajkumar et al., Chennai, India. In Int J Radiat Biol, 2012
growth rate of SiHa and HeLa transfected with dominant negative-UBE2C was significantly reduced compared to vector control
UbcH10 expression in benign, hyperplastic, and malignant endometrial curetted materials: a tissue microarray study.
Karagoz et al., Samsun, Turkey. In Int J Surg Pathol, 2012
Overexpression of UbcH10 may be a useful indicator of endometrial carcinoma.
Prognostic significance of UBE2C mRNA expression in high-risk early breast cancer. A Hellenic Cooperative Oncology Group (HeCOG) Study.
Fountzilas et al., Athens, Greece. In Ann Oncol, 2012
High UBE2C mRNA expression was found to be of adverse prognostic significance in high-risk breast cancer patients
Phospho-MED1-enhanced UBE2C locus looping drives castration-resistant prostate cancer growth.
Wang et al., Columbus, United States. In Embo J, 2011
Mediator complex subunit (MED)1 phosphorylation leads to UBE2C locus looping, UBE2C gene expression and cell growth in castration-resistant prostate cancer.
[Effect of UBE2C overexpression on the proliferation of 293T cell line].
Li et al., Shiqi, China. In Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2011
Effect of UBE2C overexpression on the proliferation of 293T cell line
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