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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Ubiquitin-conjugating enzyme E2I

Ubc9, Ubiquitin-Protein Ligase
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Four alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Ubiquitin, Smt3, CAN, UBE3A, ACID
Papers on Ubc9
Pathogen-associated molecular patterns activate expression of genes involved in cell proliferation, immunity and detoxification in the amebocyte-producing organ of the snail Biomphalaria glabrata.
Sullivan et al., Albuquerque, United States. In Dev Comp Immunol, Mar 2016
In addition to stimulating genes involved in cell proliferation, the injected substances, especially LPS, also induced expression of a number of immune-related genes including arginase, peptidoglycan recognition protein short form, tumor necrosis factor receptor, ficolin, calmodulin, bacterial permeability increasing proteins and E3 ubiquitin-protein ligase.
Allergy-Protective Arabinogalactan Modulates Human Dendritic Cells via C-Type Lectins and Inhibition of NF-κB.
Bufe et al., Bochum, Germany. In J Immunol, Feb 2016
Stimulation of these receptors with AG simultaneously with TLR4 stimulation with LPS increased the expression of the E3 ubiquitin-protein ligase tripartite motif -: containing protein 21 and decreased the phosphorylation of NF-κB p65 in DCs.
An Essential Role of Nedd4-2 in the Ubiquitination, Expression, and Function of Organic Anion Transporter-3.
You et al., United States. In Mol Pharm, Jan 2016
In the current study, we established that PKC-induced inhibition of OAT3 transport activity occurred through an enhanced OAT3 ubiquitination, a process catalyzed by an E3 ubiquitin-protein ligase Nedd4-2 (neural precursor cell expressed, developmentally downregulated 4-2).
Uncoupling phototoxicity-elicited neural dysmorphology and death by insidious function and selective impairment of Ran-binding protein 2 (Ranbp2).
Ferreira et al., Durham, United States. In Febs Lett, Jan 2016
Ranbp2(-/-)::Tg-Ranbp2(CLDm-HA) exhibit photoreceptor death-independent changes in ubiquitin-proteasome system (UPS), but death-dependent increase of ubiquitin carrier protein 9(ubc9) levels.
Utilisation of antibody microarrays for the selection of specific and informative antibodies from recombinant library binders of unknown quality.
Hoheisel et al., Heidelberg, Germany. In N Biotechnol, Jan 2016
We observed significant variation in the expression of the E3 ubiquitin-protein ligase (CHFR) as well as the glutamate receptor interacting protein 2 (GRIP2), for example, always with more than one of the scFvs binding to these targets.
Ubiquitin phosphorylation in Parkinson's disease: Implications for pathogenesis and treatment.
Li et al., Atlanta, United States. In Transl Neurodegener, Dec 2015
The identification of mutations in mitochondrial serine/threonine kinase PINK1 or E3 ubiquitin-protein ligase parkin as the cause of autosomal recessive PD opens up new avenues for uncovering neuroprotective pathways and PD pathogenic mechanisms.
Angelman Syndrome: A Review Highlighting Musculoskeletal and Anatomical Aberrations.
Kim et al., Saskatoon, Canada. In Clin Anat, Nov 2015
The cause is a known abnormality involving the maternal inherited ubiquitin-protein ligase (UBE3A) gene.
[Research Progress in the Core Proteins of the Classical Swine Fever Virus].
Zhang et al., In Bing Du Xue Bao, Sep 2015
In this review, we combine study of this protein with its disorders, structural/functional characteristics, as well as its interactions with the non-structural proteins NS3, NS5B and host proteins such as SUMO-1, UBC9, OS9 and IQGAP1.
The Keap1/Nrf2 pathway in health and disease: from the bench to the clinic.
Hayes et al., Dundee, United Kingdom. In Biochem Soc Trans, Sep 2015
Regulation of Nrf2 is complex and although much attention has focussed on its repression by Kelch-like ECH-associated protein-1 (Keap1), recently it has become increasingly apparent that it is also controlled by cross-talk with other signalling pathways including the glycogen synthase kinase-3 (GSK-3)-β-transducin repeat-containing protein (β-TrCP) axis, ERAD (endoplasmic reticulum-associated degradation)-associated E3 ubiquitin-protein ligase (Hrd1, also called synoviolin), nuclear factor-kappa B (NF-κB), Notch and AMP kinase.
Molecular mechanisms of Nrf2 regulation and how these influence chemical modulation for disease intervention.
Zhang et al., Tucson, United States. In Biochem Soc Trans, Sep 2015
Recently, both beta-transducin repeat-containing E3 ubiquitin protein ligase (β-TrCP) and E3 ubiquitin-protein ligase synoviolin (Hrd1) have been identified as novel E3 ubiquitin ligases that negatively regulate Nrf2 through Keap1-independent mechanisms.
Small ubiquitin-like modifier (SUMO) modification of E1 Cys domain inhibits E1 Cys domain enzymatic activity.
Chen et al., Duarte, United States. In J Biol Chem, 2012
Data show that the SAE2 subunit of the small ubiquitin-like modifier (SUMO) E1 is autoSUMOylated at residue Lys-236, and SUMOylation was catalyzed by Ubc9 at several additional Lys residues surrounding the catalytic Cys-173 of SAE2.
Ubc9 negatively regulates BMP-mediated osteoblastic differentiation in cultured cells.
Nakamura et al., Shiojiri, Japan. In Bone, 2012
Ubc9 negatively regulates osteoblastic differentiation induced by BMP.
Correlations among ERCC1, XPB, UBE2I, EGF, TAL2 and ILF3 revealed by gene signatures of histological subtypes of patients with epithelial ovarian cancer.
Yu et al., Morgantown, United States. In Oncol Rep, 2012
There was no statistical association of UBE2I expression between human epithelial ovarian cancer tumor and normal tissues
Elevated global SUMOylation in Ubc9 transgenic mice protects their brains against focal cerebral ischemic damage.
Hallenbeck et al., Bethesda, United States. In Plos One, 2010
expressed Ubc9 at modestly increased levels showed robust resistance to brain ischemia compared to wild type mice
GLUT4 and UBC9 protein expression is reduced in muscle from type 2 diabetic patients with severe insulin resistance.
Jessen et al., Århus, Denmark. In Plos One, 2010
UBC9 protein expression is reduced in muscle from type 2 diabetic patients with severe insulin resistance.
Arsenic trioxide controls the fate of the PML-RARalpha oncoprotein by directly binding PML.
Chen et al., Shanghai, China. In Science, 2010
Arsenic binding induces PML oligomerization, which increases its interaction with the small ubiquitin-like protein modifier (SUMO)-conjugating enzyme UBC9, resulting in enhanced SUMOylation and degradation.
Identification of a novel antibody associated with autoimmune pancreatitis.
Puccetti et al., Verona, Italy. In N Engl J Med, 2009
The peptide showed homology with an amino acid sequence of plasminogen-binding protein (PBP) of Helicobacter pylori and with ubiquitin-protein ligase E3 component n-recognin 2 (UBR2), an enzyme highly expressed in acinar cells of the pancreas.
DeTEKting ubiquitination of APC/C substrates.
Wilkinson et al., New Orleans, United States. In Cell, 2008
The APC/C ubiquitin-protein ligase targets proteins by appending polyubiquitin degradation signals that are subsequently recognized by the 26S proteasome.
Sequential E2s drive polyubiquitin chain assembly on APC targets.
Morgan et al., San Francisco, United States. In Cell, 2007
The anaphase-promoting complex (APC), or cyclosome, is an E3 ubiquitin-protein ligase that collaborates with E2 ubiquitin-conjugating enzymes to assemble polyubiquitin chains on proteins important for cell-cycle progression.
Ubc9- and mms21-mediated sumoylation counteracts recombinogenic events at damaged replication forks.
Foiani et al., Milano, Italy. In Cell, 2006
The Ubc9 SUMO-conjugating enzyme and the Siz1 SUMO ligase sumoylate several repair and recombination proteins, including PCNA.
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