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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Ubiquitin-like modifier activating enzyme 5

Uba5, UBE1DC1, ubiquitin-activating enzyme E1-domain containing 1
This gene encodes a member of the E1-like ubiquitin-activating enzyme family. This protein activates ubiquitin-fold modifier 1, a ubiquitin-like post-translational modifier protein, via the formation of a high-energy thioester bond. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. A pseudogene located on chromosome 1 has also been identified. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Ubiquitin, V1a, HAD, fibrillin-1, STEP
Papers on Uba5
RCAD/Ufl1, a Ufm1 E3 ligase, is essential for hematopoietic stem cell function and murine hematopoiesis.
New
Li et al., Wuhan, China. In Cell Death Differ, Dec 2015
The Ufm1 conjugation system is a novel ubiquitin-like modification system, consisting of Ufm1, Uba5 (E1), Ufc1 (E2) and poorly characterized E3 ligase(s).
UFBP1, a Key Component of the Ufm1 Conjugation System, Is Essential for Ufmylation-Mediated Regulation of Erythroid Development.
New
Li et al., Wuhu, China. In Plos Genet, Nov 2015
The Ufm1 conjugation system is an ubiquitin-like modification system that consists of Ufm1, Uba5 (E1), Ufc1 (E2), and less defined E3 ligase(s) and targets.
Mallory-Denk Body (MDB) formation modulates Ufmylation expression epigenetically in alcoholic hepatitis (AH) and non-alcoholic steatohepatitis (NASH).
French et al., Torrance, United States. In Exp Mol Pathol, 2014
Betaine significantly prevented transcript silencing of Ufm1, Uba5 and UfSP1 where MDBs developed and also prevented the increased expression of FAT10 and LMP7 caused by DDC re-fed mice.
Modification of ASC1 by UFM1 is crucial for ERĪ± transactivation and breast cancer development.
Chung et al., Seoul, South Korea. In Mol Cell, 2014
In contrast, expression of ufmylation-deficient ASC1 mutant or knockdown of the UFM1-activating E1 enzyme UBA5 prevented tumor growth.
Mechanistic study of Uba5 enzyme and the Ufm1 conjugation pathway.
Chen et al., Cambridge, United States. In J Biol Chem, 2014
Ubiquitin-fold modifier 1 (Ufm1) is activated by the E1 enzyme Uba5, and this pathway is proposed to play an important role in the endoplasmic reticulum (ER) stress response.
Ufmylation and FATylation pathways are downregulated in human alcoholic and nonalcoholic steatohepatitis, and mice fed DDC, where Mallory-Denk bodies (MDBs) form.
French et al., Torrance, United States. In Exp Mol Pathol, 2014
Real-time PCR analysis showed that all Ufmylation molecules (Ufm1, Uba5, Ufc1, Ufl1 and UfSPs) were significantly downregulated, both in DDC re-fed mice livers and patients' livers where MDBs had formed, indicating that gene transcript changes were limited to MDB-forming livers where the protein quality control system was downregulated.
Characterization, crystallization and preliminary X-ray crystallographic analysis of the human Uba5 C-terminus-Ufc1 complex.
Xie, Beijing, China. In Acta Crystallogr Sect F Struct Biol Commun, 2014
Human Uba5, which contains an adenylation domain and a C-terminal region, is the smallest ubiquitin-like molecule-activating enzyme.
Characterization, crystallization and preliminary X-ray crystallographic analysis of the Uba5 fragment necessary for high-efficiency activation of Ufm1.
Xie, Beijing, China. In Acta Crystallogr Sect F Struct Biol Commun, 2014
Uba5 is the smallest ubiquitin-like molecule-activating enzyme and contains an adenylation domain and a C-terminal region.
Transcriptional regulation of the Ufm1 conjugation system in response to disturbance of the endoplasmic reticulum homeostasis and inhibition of vesicle trafficking.
Li et al., Augusta, United States. In Plos One, 2011
Genetic study has demonstrated that the Ufm1-activating enzyme Uba5 is indispensible for erythroid differentiation in mice, highlighting the importance of this novel system in animal development.
The Ufm1-activating enzyme Uba5 is indispensable for erythroid differentiation in mice.
GeneRIF
Komatsu et al., Tokyo, Japan. In Nat Commun, 2010
The Ufm1-activating enzyme Uba5 is indispensable for erythroid differentiation in mice.
Mitochondrial associated ubiquitin fold modifier-1 mediated protein conjugation in Leishmania donovani.
Nakhasi et al., Bethesda, United States. In Plos One, 2010
Immunofluorescence experiments showed that Leishmania Ufm1, Uba5 and Ufc1 are associated with the mitochondria.
Crystal structure of the human ubiquitin-activating enzyme 5 (UBA5) bound to ATP: mechanistic insights into a minimalistic E1 enzyme.
GeneRIF
Dhe-Paganon et al., Toronto, Canada. In J Biol Chem, 2010
Studies reveal structural features of UBA5 that further understanding of the enzyme reaction mechanism and provide insight into the evolution of ubiquitin activation.
A novel type of E3 ligase for the Ufm1 conjugation system.
Komatsu et al., Tokyo, Japan. In J Biol Chem, 2010
Ufm1 is known to covalently attach with cellular protein(s) via a specific E1-activating enzyme (Uba5) and an E2-conjugating enzyme (Ufc1), but its E3-ligating enzyme(s) as well as the target protein(s) remain unknown.
NMR and X-RAY structures of human E2-like ubiquitin-fold modifier conjugating enzyme 1 (UFC1) reveal structural and functional conservation in the metazoan UFM1-UBA5-UFC1 ubiquination pathway.
Szyperski et al., Buffalo, United States. In J Struct Funct Genomics, 2009
For cell regulation, E2-like ubiquitin-fold modifier conjugating enzyme 1 (Ufc1) is involved in the transfer of ubiquitin-fold modifier 1 (Ufm1), a ubiquitin like protein which is activated by E1-like enzyme Uba5, to various target proteins.
UBE1DC1, an ubiquitin-activating enzyme, activates two different ubiquitin-like proteins.
GeneRIF
Mao et al., Shanghai, China. In J Cell Biochem, 2008
UBE1DC1 greatly activated SUMO2 in the nucleus or transferred activated-SUMO2 to nucleus after it conjugated SUMO2 in the cytoplasm.
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