Autoimmune ovarian disease: mechanism of disease induction and prevention
In The Journal of Experimental Medicine, 1996
... The cDNAs encoding human Ro60, 70 kD U1-RNP (gifts from Jack Keene, Duke University, Durham, NC), SmB and SmD (from Joe Craft, Yale University, New Haven, CT), were cloned into the pQE expression vectors (Qiagen Inc., Chatsworth, CA) to ...
Association of HLA-DRB1 alleles with susceptibility to mixed connective tissue disease in Polish patients.
Warsaw, Poland. In Tissue Antigens, Dec 2015
UNASSIGNED: Mixed connective tissue disease (MCTD) is a systemic autoimmune disease, originally defined as a connective tissue inflammatory syndrome with overlapping features of systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), polymyositis/dermatomyositis (PM/DM) and systemic sclerosis (SSc), characterized by the presence of antibodies against components of the U1 small nuclear ribonucleoprotein (U1snRNP).
The clinical phenotype associated with myositis-specific and associated autoantibodies: a meta-analysis revisiting the so-called antisynthetase syndrome.
Lyon, France. In Autoimmun Rev, 2014
Two investigators independently extracted data on study design, patient characteristics, and clinical features (interstitial lung disease [ILD], fever, mechanic's hands [MH], Raynaud's phenomenon [RPh], arthralgia, sclerodactyly, cancer and dermatomyositis-specific rash) according to the presence of myositis-specific (anti-aminoacyl-transfer RNA synthetase [ARS], anti-signal recognition particle [anti-SRP] and anti-Mi2) and myositis-associated (anti-PM/Scl, anti-U1-RNP and anti-Ku) autoantibodies.
The diagnosis and classification of mixed connective tissue disease.
Pisa, Italy. In J Autoimmun, 2014
The term "mixed connective tissue disease" (MCTD) concerns a systemic autoimmune disease typified by overlapping features between two or more systemic autoimmune diseases and the presence of antibodies against the U1 small nuclear ribonucleoprotein autoantigen (U1snRNP).
Crystal structure of human spliceosomal U1 snRNP at 5.5 A resolution.
Cambridge, United Kingdom. In Nature, 2009
Human spliceosomal U1 small nuclear ribonucleoprotein particles (snRNPs), which consist of U1 small nuclear RNA and ten proteins, recognize the 5' splice site within precursor messenger RNAs and initiate the assembly of the spliceosome for intron excision.
Gene silencing by synthetic U1 adaptors.
United States. In Nat Biotechnol, 2009
U1 Adaptors are bifunctional oligonucleotides with a 'target domain' complementary to a site in the target gene's terminal exon and a 'U1 domain' that binds to the U1 small nuclear RNA component of the U1 small nuclear ribonucleoprotein (U1 snRNP) splicing factor.