Mechanisms of autoantibody production in systemic lupus erythematosus.
Gainesville, United States. In Front Immunol, 2014
We show that the levels of autoantibodies against the U1A protein (part of a ribonucleoprotein) are markedly higher than autoantibodies against other antigens, including dsDNA and the non-nucleic acid-associated autoantigens insulin and thyroglobulin.
Multistep kinetics of the U1A-SL2 RNA complex dissociation.
Urbana, United States. In J Mol Biol, 2011
An analysis of the kinetic data suggests three phases of U1A-SL2 RNA complex dissociation with time scales of approximately 100 mus, approximately 50 ms, and approximately 2 s. We propose that the first step of dissociation is a fast rearrangement of the complex to form a loosely bound complex.