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Dual specificity phosphatase 4

Typ, VH2, MKP-2, DUSP4
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript variants, encoding distinct isoforms, have been observed for this gene. In addition, multiple polyadenylation sites have been reported. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: MKP-1, ERK, MAPK, JNK, ERK1
Papers on Typ
ANGIOTENSIN 1-7/MAS INHIBITS APOPTOSIS IN ALVEOLAR EPITHELIAL CELLS THROUGH UPREGULATION OF MAP KINASE PHOSPHATASE-2.
New
Uhal et al., United States. In Am J Physiol Lung Cell Mol Physiol, Jan 2016
Therefore in the current study, it was theorized that ANG 1-7 activates a map kinase phosphatase (MKP) and thereby reduces JNK phosphorylation to inhibit apoptosis and promote cell survival.
Imbalanced signal transduction in regulatory T cells expressing the transcription factor FoxP3.
New
Benoist et al., Boston, United States. In Proc Natl Acad Sci U S A, Jan 2016
Candidate regulators were tested, but the Treg/Tconv differential could not be explained by overexpression in Treg cells of the signaling modulator CD5, the coinhibitors PD-1 and CTLA4, or the regulatory phosphatase DUSP4.
Modulation of p38 kinase by DUSP4 is important in regulating cardiovascular function under oxidative stress.
New
Chen et al., Columbus, United States. In Free Radic Biol Med, Dec 2015
Previously, we demonstrated that N-acetyl cysteine (NAC) pretreatment up-regulates DUSP4 expression in endothelial cells, regulating p38 and ERK1/2 activities, and thus providing a protective effect against oxidative stress.
Mitogen-Dependent Regulation of DUSP1 Governs ERK and p38 Signaling During Early 3T3-L1 Adipocyte Differentiation.
New
Morrison et al., Baton Rouge, United States. In J Cell Physiol, Dec 2015
In support of this, qRT-PCR identified several MAPK-specific DUSPs induced during early (DUSP2, -4, -5, & -6), mid (DUSP4 & -16) and late (DUSP9) stages of adipocyte differentiation.
Differential expression profiles and roles of inducible DUSPs and ERK1/2-specific constitutive DUSP6 and DUSP7 in microglia.
New
Choi et al., Seoul, South Korea. In Biochem Biophys Res Commun, Dec 2015
LPS induced expression of DUSP1, DUSP2, and DUSP5 within 60 min, whereas DUSP4 expression was induced more slowly.
Simian hemorrhagic fever virus: Recent advances.
Review
New
Vatter et al., Atlanta, United States. In Virus Res, May 2015
The catalytic Cys of PLP1α is unusual in being adjacent to an Ala instead of a Typ.
Genetic variants identified by GWAS was associated with colorectal cancer in the Han Chinese population.
New
Cao et al., Suzhou, China. In J Cancer Res Ther, Apr 2015
CONCLUSION: Our findings supported that rs11987193 is a susceptibility locus for CRC, and gene DUSP4 was possible to play a role in the pathology of CRC.
Dual-Specificity Phosphatase 4 Regulates STAT5 Protein Stability and Helper T Cell Polarization.
Huang et al., Taiwan. In Plos One, 2014
Our previous results found that the deficiency of a dual-specificity phosphatase, DUSP4, induced STAT5 hyper-activation, enhanced IL-2 signaling, and increased T cell proliferation.
Draft Genome Sequences of the Fish Pathogen Vibrio harveyi Strains VH2 and VH5.
Katharios et al., Copenhagen, Denmark. In Genome Announc, 2014
Here, we announce the draft genome sequences of V. harveyi strains VH2 and VH5, isolated from farmed juvenile Seriola dumerili during outbreaks of vibriosis in Crete, Greece.
Methylome sequencing for fibrolamellar hepatocellular carcinoma depicts distinctive features.
Issa et al., Houston, United States. In Epigenetics, 2014
Furthermore, we identified several putative tumor suppressor genes (e.g., DLEU7) and oncogenes (e.g., DUSP4).
Targeting DUSPs in glioblastomas - wielding a double-edged sword?
Review
Velpula et al., Lakeland, United States. In Cell Biol Int, 2014
This review identifies and summarize the specific roles of DUSP1, DUSP4, DUSP6 and DUSP26 that have been implicated in GBM.
Current pharmacological treatment options for male lower urinary tract symptoms.
Review
Hedlund et al., München, Germany. In Expert Opin Pharmacother, 2013
Recently, a variety of novel substances have been tested which include Phosphodiesterase Typ 5 inhibitors (PDE5i), anti-cholinergic agents and β-3-agonists.
Mitogen-activated protein kinase phosphatase 2, MKP-2, regulates early inflammation in acute lung injury.
GeneRIF
Shanley et al., Ann Arbor, United States. In Am J Physiol Lung Cell Mol Physiol, 2012
Loss of MKP-2 regulates early inflammation in acute lung injury.
Profiling of residual breast cancers after neoadjuvant chemotherapy identifies DUSP4 deficiency as a mechanism of drug resistance.
Impact
Arteaga et al., Nashville, United States. In Nat Med, 2012
Low concentrations of dual specificity protein phosphatase 4 (DUSP4), an ERK phosphatase, correlated with high post-NAC tumor cell proliferation and with basal-like breast cancer (BLBC) status.
Signal inhibition by the dual-specific phosphatase 4 impairs T cell-dependent B-cell responses with age.
GeneRIF
Goronzy et al., Stanford, United States. In Proc Natl Acad Sci U S A, 2012
Increased DUSP4 expression in activated T cells in the elderly in part accounts for defective adaptive immune responses.
DUSP4 deficiency enhances CD25 expression and CD4+ T-cell proliferation without impeding T-cell development.
GeneRIF
Tan et al., Taiwan. In Eur J Immunol, 2012
protein deficiency enhances CD25 expression and CD4+ T-cell proliferation without impeding T-cell development
Deletion of the dual specific phosphatase-4 (DUSP-4) gene reveals an essential non-redundant role for MAP kinase phosphatase-2 (MKP-2) in proliferation and cell survival.
GeneRIF
Plevin et al., Glasgow, United Kingdom. In J Biol Chem, 2011
a critical non-redundant role for MKP-2 in regulating cell cycle progression and apoptosis.
Post-translational regulation of mitogen-activated protein kinase phosphatase-2 (MKP-2) by ERK.
GeneRIF
Wu et al., Detroit, United States. In Cell Cycle, 2011
MKP-2 is phosphorylated by ERK and that such phosphorylation leads to stabilization of MKP-2 protein.
Mitogen activated protein kinase phosphatases and cancer.
Review
Wu et al., Detroit, United States. In Cancer Biol Ther, 2010
Most of what is known centers on MKP-1, MKP-2 and MKP-3.
[Hereditary hemochromatosis].
Review
Niederau, Essen, Germany. In Med Klin (munich), 2010
Typ 3 has mainly been described in Italian families and refers to mutations in transferrin receptor 2 gene.
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