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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Thioredoxin domain containing 5

TXNDC5, ERp46, thioredoxin domain containing 5, EndoPDI, PC-TRP
This gene encodes a protein-disulfide isomerase. Its expression is induced by hypoxia and its role may be to protect hypoxic cells from apoptosis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring upstream MUTED (muted homolog) gene. [provided by RefSeq, Dec 2010] (from NCBI)
Top mentioned proteins: Thioredoxin, CAN, alpha-Synuclein, adiponectin, V1a
Papers using TXNDC5 antibodies
ERO1-beta, a pancreas-specific disulfide oxidase, promotes insulin biogenesis and glucose homeostasis
Bulleid Neil J et al., In The EMBO Journal, 2009
... Frontier (Seoul, Korea), rabbit polyclonal anti-calreticulin was purchased from Stressgen (Exeter, UK) and rabbit polyclonal anti-ERp46 was purchased from AbCam (Cambridge, UK) ...
Papers on TXNDC5
Reduced expression of ERp46 under diabetic conditions in β-cells and the effect of liraglutide.
Charonis et al., Athens, Greece. In Metabolism, Jan 2016
Proteomic analysis revealed a number of proteins involved in glucose toxicity, while further biochemical analysis identified the endoplasmic reticulum protein ERp46 as a molecule with a possible role in insulin production at the post-translational level.
Enhanced photoelectrochemical aptasensing platform for TXNDC5 gene based on exciton energy transfer between NCQDs and TiO2 nanorods.
Wei et al., Jinan, China. In Sci Rep, Dec 2015
The over expression of thioredoxin domain-containing protein 5 (TXNDC5) can promote the growth of castration-resistant prostate cancer (CRPC).
The role of TXNDC5 in castration-resistant prostate cancer-involvement of androgen receptor signaling pathway.
Han et al., Jinan, China. In Oncogene, Oct 2015
Thioredoxin domain-containing protein 5 (TXNDC5) is involved in protein folding and chaperone activity, and its overexpression has been reported in multiple malignancies.
miR-573 is a negative regulator in the pathogenesis of rheumatoid arthritis.
Chang et al., Jinan, China. In Cell Mol Immunol, Aug 2015
Our previous study demonstrated an increased expression of thioredoxin domain containing 5 (TXNDC5) in the synovial tissues of RA, and its overexpression was implicated in RA pathology.
Glucagon-like peptide-1 preserves non-alcoholic fatty liver disease through inhibition of the endoplasmic reticulum stress-associated pathway.
Du et al., Shenyang, China. In Hepatol Res, Aug 2015
In vitro, HepG2 cells were exposed to 0.4 mM palmitate fatty acid and treated with different concentrations of GLP-1, and ER protein 46 (ERp46) and ER stress pathways were analyzed.
Analysis of loss-of-function variants and 20 risk factor phenotypes in 8,554 individuals identifies loci influencing chronic disease.
Boerwinkle et al., Houston, United States. In Nat Genet, Jun 2015
Previously unknown relationships included elevated fasting glucose in carriers of heterozygous LOF variation in TXNDC5, which encodes a biomarker for type 1 diabetes progression, and apparent recessive effects of C1QTNF8 on serum magnesium levels.
An immunohistochemical study of thioredoxin domain-containing 5 expression in gastric adenocarcinoma.
Zhang et al., Beijing, China. In Oncol Lett, Mar 2015
UNASSIGNED: Thioredoxin domain-containing 5 (TXNDC5) is overexpressed in a number of human carcinomas.
Inhibition of PCSK6 may play a protective role in the development of rheumatoid arthritis.
Pan et al., Zibo, China. In J Rheumatol, Feb 2015
These changes in RASF appeared to be related to reduced tumor necrosis factor-α secretion, G0/G1 arrest, and altered expression of various proteins including those involved in angiogenesis (matrix metalloproteinase 9, nitric oxide synthase trafficking), hypoxia (hypoxia-inducible factor-α, thioredoxin domain containing 5), proliferation (chromosome 10 open reading frame 116), and inflammation [CCL7, chemokine (C-X-C motif) ligand 9, interleukin 26].
Analysis of patents on anti-rheumatoid arthritis therapies issued in China.
Wei et al., Nanjing, China. In Expert Opin Ther Pat, 2014
In addition, it is expected that new targets such as high-mobility group protein B1, thioredoxin domain-containing protein 5 (TXNDC5) and B lymphocyte stimulator (BlyS) will play a significant role in RA as potential targets for new treatments.
Nuclear Receptor 4A1 (NR4A1) as a Drug Target for Renal Cell Adenocarcinoma.
Abudayyeh et al., College Station, United States. In Plos One, 2014
NR4A1 activates mTOR signaling, regulates genes such as thioredoxin domain containing 5 and isocitrate dehydrogenase 1 that maintain low oxidative stress, and coactivates specificity protein 1 (Sp1)-regulated pro-survival and growth promoting genes.
[TXNDC5 mediates serum starvation-induced proliferation inhibition of HeLa cell].
Chen et al., Beijing, China. In Zhongguo Yi Xue Ke Xue Yuan Xue Bao, 2014
OBJECTIVE: To investigate the role of TXNDC5 in serum starvation-induced proliferation inhibition of HeLa cell.
Inactivation of mammalian Ero1α is catalysed by specific protein disulfide-isomerases.
Bulleid et al., Glasgow, United Kingdom. In Biochem J, 2014
However, specific members of the PDI family, such as PDI or ERp46 (endoplasmic reticulum-resident protein 46), were able to catalyse this process.
Differential placental gene expression in term pregnancies affected by fetal growth restriction and macrosomia.
Hyett et al., Sydney, Australia. In Fetal Diagn Ther, 2013
CPXM2 and CLDN1 were upregulated and TXNDC5 and LRP2 downregulated in fetal growth restriction.
TXNDC5, a newly discovered disulfide isomerase with a key role in cell physiology and pathology.
Osada et al., Zaragoza, Spain. In Int J Mol Sci, 2013
Thioredoxin domain-containing 5 (TXNDC5) is a member of the protein disulfide isomerase family, acting as a chaperone of endoplasmic reticulum under not fully characterized conditions As a result, TXNDC5 interacts with many cell proteins, contributing to their proper folding and correct formation of disulfide bonds through its thioredoxin domains.
Structure of the third catalytic domain of the protein disulfide isomerase ERp46.
Gehring et al., Montréal, Canada. In Acta Crystallogr Sect F Struct Biol Cryst Commun, 2012
crystal structure of the third catalytic domain of protein disulfide isomerase ERp46 (also known as protein disulfide isomerase A5 and TXNDC5) was determined to 2.0 A resolution
Overexpression of the TXNDC5 protein in non-small cell lung carcinoma.
Tavaré et al., Bristol, United Kingdom. In Anticancer Res, 2011
Overexpression of the TXNDC5 protein is associated with non-small cell lung carcinoma.
Investigating a pathogenic role for TXNDC5 in rheumatoid arthritis.
Wang et al., Jinan, China. In Arthritis Res Ther, 2010
TXNDC5 has a genetic effect on the risk of rheumatoid arthritis and ankylosing spondylitis
The influence of TXNDC5 gene on gastric cancer cell.
Zhai et al., Beijing, China. In J Cancer Res Clin Oncol, 2010
TXNDC5 can promote the growth and proliferation of gastric cells. Silencing of TXNDC5 can restrain the growth and proliferation of gastric cancer cells.
Involvement of thioredoxin domain-containing 5 in resistance to nitrosative stress.
Cao et al., United States. In Free Radic Biol Med, 2010
Potential role for TXNDC5 in resistance to nitrosative stress.
Molecular mechanisms of signal transduction via adiponectin and adiponectin receptors.
Beck-Sickinger et al., Leipzig, Germany. In Biol Chem, 2010
Several intracellular binding partners of the AdipoR N-terminus such as APPL1, CK2ß; and ERp46 have been identified and shown to control receptor signaling.
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