gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Thromboxane A2 receptor

TXA2
Top mentioned proteins: ACID, cyclooxygenase, HAD, V1a, CAN
Papers on TXA2
Decreased bioavailability of nitric oxide in aorta from ovariectomized senescent mice. Role of cyclooxygenase.
New
Medina et al., Valencia, Spain. In Exp Gerontol, Feb 2016
Our results indicate that NO bioavailability in response to TP receptor activation is both estrogen- and aging-dependent.
ATP-binding cassette transporter 1 (ABCA1) deficiency decreases platelet reactivity and reduces TXA2 production independently of hematopoietic ABCA1.
New
Payrastre et al., Toulouse, France. In J Thromb Haemost, Feb 2016
Interestingly, ABCA1-deficient platelets display a reduction in positive feedback loop mechanisms, particularly in thromboxane A2 (TXA2) production.
The effects of centrally injected arachidonic acid on respiratory system; Involvement of cyclooxygenase to thromboxane signaling pathway.
New
Yalcin et al., Bursa, Turkey. In Respir Physiol Neurobiol, Feb 2016
Therefore, the present study was designed to investigate the possible effects of centrally injected AA on respiratory system and the mediation of the central cyclooxygenase (COX) to thromboxane A2 (TXA2) signaling pathway on AA-induced respiratory effects in anaesthetized rats.
Wall stretch and thromboxane A2 activate NO synthase (eNOS) in pulmonary arterial smooth muscle cells via H2O2 and Akt-dependent phosphorylation.
New
Kim et al., Seoul, South Korea. In Pflugers Arch, Feb 2016
In the myograph study of endothelium-denuded rat PAs, NOS inhibition (L-NAME) induced strong contraction (96 % of 80 mM KCl-induced contraction (80K)) in the presence of 5 nM U46619 (thromboxane A2 (TXA2) analogue) with relatively high basal stretch (2.94 mN, S(+)).
PUFAs: Structures, Metabolism and Functions.
Review
New
Nowak et al., Łódź, Poland. In Adv Clin Exp Med, Nov 2015
In an organism, aracidonic acid (ARA) is converted to prostanoids series 2 (PGE2, PGI2, TXA2) and leukotrienes series 4 (LTB4, LTC4, LTD4) which are endowed with pro-inflammatory potential and are able to induce platelet aggregation and vasoconstriction.
Can active components of licorice, glycyrrhizin and glycyrrhetinic acid, lick rheumatoid arthritis?
Review
New
Huang et al., Guangzhou, China. In Oncotarget, Nov 2015
OBJECTIVES: This review stated the possible application of the active components of licorice, glycyrrhizin (GL) and glycyrrhetinic acid (GA), in rheumatoid arthritis (RA) treatment based on the cyclooxygenase (COX)-2/thromboxane A2 (TxA2) pathway.
The receptor EP3 to PGE2: A rational target to prevent atherothrombosis without inducing bleeding.
Review
New
Fabre et al., Paris, France. In Prostaglandins Other Lipid Mediat, Sep 2015
The prostanoid E2 (PGE2) is known to modulate the aggregative response of platelets to their conventional agonists such as ADP, TXA2, thrombin or collagen.
[Inhibitory effects and mechanisms of snake venom tripeptide pENW on platelet adhesion].
New
Li et al., In Yao Xue Xue Bao, Sep 2015
In addition, pENW attenuated intracellular Ca2+ mobilization and TXA2 production in platelets stimulated by thrombin.
Blood platelet: a review of its characteristics and function in acute malaria infection.
Review
Emagba et al., In Afr J Med Med Sci, 2014
The evidence in support of this view includes associated findings of elevated plasma concentrations of Beta-thromboglobulin (BTG) and Platelet Factor 4 (PF4) as well as enhanced production of Thromboxane A2 (TXA2) and 6-keto prostaglandin F1α (6-KPF1α).
11-deoxy prostaglandin F(2α), a thromboxane A2 receptor agonist, partially alleviates embryo crowding in Lpar3((-/-)) females.
GeneRIF
Chun et al., Athens, United States. In Fertil Steril, 2012
The thromboxane A(2) receptor agonist 11-deoxy PGF(2alpha) can partially alleviate embryo crowding in the Lpar3((-/-)) females and embryo crowding likely contributes to reduced litter size in the Lpar3((-/-)) females.
Thromboxane receptor activation enhances striatal dopamine release, leading to suppression of GABAergic transmission and enhanced sugar intake.
GeneRIF
Narumiya et al., Kyoto, Japan. In Eur J Neurosci, 2011
We show here that thromboxane receptor in the striatum locally facilitates dopamine overflow.
Thromboxane receptor signalling in renal ischemia reperfusion injury.
GeneRIF
van Heurn et al., Maastricht, Netherlands. In Free Radic Res, 2011
thromboxane A2 receptor signalling does not contribute critically to the pathogenesis of ischemic acute kidney injury
Activation of NAD(P)H oxidases by thromboxane A2 receptor uncouples endothelial nitric oxide synthase.
GeneRIF
Zou et al., Oklahoma City, United States. In Arterioscler Thromb Vasc Biol, 2011
Thromboxane A2 receptor activation via PKC-zeta-mediated NAD(P)H oxidase activation increases superoxide and peroxynitrite, resulting in eNOS uncoupling in endothelial cells.
Phenotypic approaches to gene mapping in platelet function disorders - identification of new variant of P2Y12, TxA2 and GPVI receptors.
Review
GeneRIF
Mumford et al., Birmingham, United Kingdom. In Hamostaseologie, 2010
Genetic variations exist in this protein in platelet function disorders.
Prostacyclin protects against elevated blood pressure and cardiac fibrosis.
Impact
Coffman et al., Durham, United States. In Cell Metab, 2005
Coincidental deletion of the TxA2 (TP) receptor does not prevent the development of hypertension, but cardiac hypertrophy is ameliorated and fibrosis is prevented in IPTP double knockouts (DKOs).
Thromboxane A2 modulates interaction of dendritic cells and T cells and regulates acquired immunity.
Impact
GeneRIF
Narumiya et al., Kyoto, Japan. In Nat Immunol, 2003
TXA2-TP signaling modulates acquired immunity by negatively regulating DC-T cell interactions.
Role of prostacyclin in the cardiovascular response to thromboxane A2.
Impact
FitzGerald et al., Philadelphia, United States. In Science, 2002
Here we show that injury-induced vascular proliferation and platelet activation are enhanced in mice that are genetically deficient in the PGI2 receptor (IP) but are depressed in mice genetically deficient in the TxA2 receptor (TP) or treated with a TP antagonist.
Directed vascular expression of the thromboxane A2 receptor results in intrauterine growth retardation.
Impact
FitzGerald et al., Philadelphia, United States. In Nat Med, 2000
TxA2 exerts its effects through a membrane receptor (TP), of which two isoforms (alpha and beta; refs.
Prostacyclin and thromboxane changes predating clinical onset of preeclampsia: a multicenter prospective study.
Impact
Levine et al., Bethesda, United States. In Jama, 1999
Because most trials using aspirin to reduce TxA2 production have failed to prevent preeclampsia, it is critical to determine whether eicosanoid changes occur before the onset of clinical disease or are secondary to clinical manifestations of preeclampsia.
Cytoprotective Role of Prostaglandin D2 DP1 Receptor against Neuronal Injury Following Acute Excitotoxicity and Cerebral Ischemia
Review
Shafique Ahmad et al., Boca Raton, United States. In Unknown Journal, 0001
At that point, through a coordinated system, all prostaglandin (PG) syntheses generate specific prostanoids, which are members of fatty acids that include PGD2, PGE2, PGF2α, PGI2, and TxA2.
share on facebooktweetadd +1mail to friends