PUFAs: Structures, Metabolism and Functions.
Łódź, Poland. In Adv Clin Exp Med, Nov 2015
In an organism, aracidonic acid (ARA) is converted to prostanoids series 2 (PGE2, PGI2, TXA2) and leukotrienes series 4 (LTB4, LTC4, LTD4) which are endowed with pro-inflammatory potential and are able to induce platelet aggregation and vasoconstriction.
Role of prostacyclin in the cardiovascular response to thromboxane A2.
Philadelphia, United States. In Science, 2002
Here we show that injury-induced vascular proliferation and platelet activation are enhanced in mice that are genetically deficient in the PGI2 receptor (IP) but are depressed in mice genetically deficient in the TxA2 receptor (TP) or treated with a TP antagonist.