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Twinfilin, actin-binding protein, homolog 2

twinfilin-2, A6R, A6rp, A6-related protein
The protein encoded by this gene was identified by its interaction with the catalytic domain of protein kinase C-zeta. The encoded protein contains an actin-binding site and an ATP-binding site. It is most closely related to twinfilin (PTK9), a conserved actin monomer-binding protein. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: A-6, ACID, Actin, STEP, fibrillin-1
Papers on twinfilin-2
Verification of a Parkinson's disease protein signature in T-lymphocytes by multiple reaction monitoring.
Fasano et al., Busto Arsizio, Italy. In J Proteome Res, 2014
A similar result is achieved by evaluating all peptides of a selected panel of proteins (gelsolin, moesin, septin-6, twinfilin-2, lymphocyte-specific protein 1, vimentin, transaldolase), with an area under the curve of 0.840.
Interaction between a cationic surfactant-like peptide and lipid vesicles and its relationship to antimicrobial activity.
Ruokolainen et al., Reading, United Kingdom. In Langmuir, 2013
We investigate the properties of an antimicrobial surfactant-like peptide (Ala)6(Arg), A6R, containing a cationic headgroup.
Twinfilin-2a is dispensable for mouse development.
GeneRIF
Lappalainen et al., Helsinki, Finland. In Plos One, 2010
These data suggest that twinfilin-2a plays a redundant role in cytoskeletal dynamics with the biochemically similar twinfilin-1, which is typically co-expressed in same tissues with twinfilin-2a.
Twinfilin 2 regulates actin filament lengths in cochlear stereocilia.
GeneRIF
Heller et al., Stanford, United States. In J Neurosci, 2010
This study suggested that twinfilin 2 plays a role in the regulation of stereocilia elongation by restricting excessive elongation of the shorter row stereocilia thereby maintaining the mature staircase architecture of cochlear hair bundles.
Two biochemically distinct and tissue-specific twinfilin isoforms are generated from the mouse Twf2 gene by alternative promoter usage.
GeneRIF
Lappalainen et al., Helsinki, Finland. In Biochem J, 2009
like Twf1, mouse Twf2 is a filament barbed-end capping protein, and that two tissue-specific and biochemically distinct isoforms are generated from the Twf2 gene through alternative promoter usage
Inhibition of monkeypox virus replication by RNA interference.
Ibrahim et al., United States. In Virol J, 2008
Seven siRNA constructs from these two pools, targeting either an essential gene for viral replication (A6R) or an important gene in viral entry (E8L), inhibited viral replication in cell culture by 65-95% with no apparent cytotoxicity.
MyosinVIIa interacts with Twinfilin-2 at the tips of mechanosensory stereocilia in the inner ear.
GeneRIF
Steel et al., Cambridge, United Kingdom. In Plos One, 2008
MyosinVIIa interacts with Twinfilin-2 at the tips of mechanosensory stereocilia in the inner ear
Identification of twinfilin-2 as a factor involved in neurite outgrowth by RNAi-based screen.
GeneRIF
Miyake et al., Tokyo, Japan. In Biochem Biophys Res Commun, 2007
twinfilin-2 is a protein that is involved in neurite outgrowth
Characterising alternate splicing and tissue specific expression in the chicken from ESTs.
Hubbard et al., Manchester, United Kingdom. In Cytogenet Genome Res, 2006
Genes which display notable biases were analysed in more detail, including twinfilin-2 and embryonic heavy chain myosin.
Structure and ethanol complexation of cyclic tetrasaccharide in aqueous solution studied by NMR and molecular mechanics.
Nishimoto et al., Kyoto, Japan. In Chem Pharm Bull (tokyo), 2004
The overlapped signals of protons A5, A6S, A6R, B3, B6S and B6R were resolved by spectral simulations to determine their chemical shifts and vicinal coupling constants.
Mammals have two twinfilin isoforms whose subcellular localizations and tissue distributions are differentially regulated.
Lappalainen et al., Helsinki, Finland. In J Biol Chem, 2003
Here we show that this protein, which we named twinfilin-2, is indeed an actin monomer-binding protein.
Cloning, expression and characterization of an A6-related protein.
Gschwendt et al., Heidelberg, Germany. In Eur J Biochem, 1999
The deduced amino acid sequence (349 amino acids) of the A6-related protein (A6rp) contained potential actin-binding sites and ATP-binding sites.
Design and study of peptide-ligand affinity chromatography adsorbents: application to the case of trypsin purification from bovine pancreas.
Clonis et al., Athens, Greece. In Biotechnol Bioeng, 1997
Each tripeptide-ligand was immobilized via its N-terminal amino group on Ultrogel A6R agarose gel, which was previously activated with low concentrations of cyanuric chloride (10.5 to 42.5 micromol/g gel).
Biomimetic-dye affinity chromatography for the purification of mitochondrial L-malate dehydrogenase from bovine heart.
Clonis et al., Athens, Greece. In J Biotechnol, 1996
Seven biomimetic anthraquinone triazinyl dye-ligands, bearing as triazine-linked terminal moiety (keto)carboxylated structures mimicking substrates and inhibitors of malate dehydrogenase (MDH), were immobilised on cross-linked agarose Ultrogel A6R.
Biomimetic-dye affinity adsorbents for enzyme purification: application to the one-step purification of Candida boidinii formate dehydrogenase.
Clonis et al., Athens, Greece. In Biotechnol Bioeng, 1995
For this purpose, seven' biomimetic analogues of the monochlorotriazine dye, Cibacron(R) Blue 3GA (CB3GA), and parent dichloro-triazine dye, Vilmafix Blue A-R (VBAR), bearing a car-boxylated structure as their terminal biomimetic moiety, were immobilized on crosslinked agarose gel, Ultrogel A6R.
Corn phosphoglycolate phosphatase: purification and properties.
Baldy et al., Toulouse, France. In Planta, 1986
The purification procedure included Sephadex G-75 filtration, and diethylaminoethyl-cellulose and Phospho-Ultrogel A6R chromatography.
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