Regulation of mTORC1 by PI3K signaling.
Boston, United States. In Trends Cell Biol, 30 Sep 2015
We focus on how PI3K-dependent activation of Akt and spatial regulation of the tuberous sclerosis complex (TSC) complex (TSC complex) [composed of TSC1, TSC2, and Tre2-Bub2-Cdc16-1 domain family member 7 (TBC1D7)] switches on Rheb at the lysosome, where mTORC1 is activated.
mTORC1 and mTORC2 have largely distinct functions in Purkinje cells.
Basel, Switzerland. In Eur J Neurosci, 22 Sep 2015
Comparison of mTORC1-deficient Purkinje cells with those deficient for the mTORC1 inhibitor TSC1 revealed a striking overlap in Purkinje cell degeneration and death, which included neurofilamentopathy and reactive gliosis.
The PTEN Tumor Suppressor Forms Homodimers in Solution.
Pittsburgh, United States. In Structure, 19 Sep 2015
UNASSIGNED: As the phosphoinositol-3-kinase antagonist in the PI3K pathway, the PTEN tumor suppressor exerts phosphatase activity on diacylphosphatidylinositol triphosphate in the plasma membrane.
Mammalian target of rapamycin and tuberous sclerosis complex.
Ōsaka, Japan. In J Dermatol Sci, 31 Aug 2015
TSC is a multiple hamartomas syndrome with epilepsy, autism, mental retardation and hypopigmented macules that are caused by the constitutive activation of mTORC1 resulting from genetic mutation of TSC1 or TSC2.
Akt3 promotes prostate cancer proliferation cells through regulation of Akt, B-Raf, & TSC1/TSC2.
Taiwan. In Oncotarget, 10 Aug 2015
Overexpression of AKT3 increased the protein expression of total AKT, phospho-AKT S473, phospho-AKT T308, B-Raf, c-Myc, Skp2, cyclin E, GSK3β, phospho-GSK3β S9, phospho-mTOR S2448, and phospho-p70S6K T421/S424, but decreased TSC1 (tuberous sclerosis 1) and TSC2 (tuberous Sclerosis Complex 2) proteins in PC-3 PCa cells.
Tuberous sclerosis complex.
Hartford, United States. In Pediatr Clin North Am, Jun 2015
The genetic cause is mutations in the TSC1 gene, found on chromosome 9q34, and TSC2 gene, found on chromosome 16p13.
Coordinated regulation of protein synthesis and degradation by mTORC1.
Boston, United States. In Nature, Oct 2014
Genetic activation of mTORC1 through loss of the tuberous sclerosis complex tumour suppressors, TSC1 or TSC2, or physiological activation of mTORC1 in response to growth factors or feeding resulted in increased NRF1 expression in cells and tissues.
Molecular genetics of clear-cell renal cell carcinoma.
Dallas, United States. In J Clin Oncol, Jul 2014
Several additional tumor suppressor genes have been identified near the VHL gene, within a region that is frequently deleted in ccRCC on chromosome 3p: SETD2, BAP1, and PBRM1.