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Tubby like protein 3

Tulp3, tubby-like protein 3
This gene encodes a member of the tubby gene family of bipartite transcription factors. Members of this family have been identified in plants, vertebrates, and invertebrates, and they share a conserved N-terminal transcription activation region and a conserved C-terminal DNA and phosphatidylinositol-phosphate binding region. The encoded protein binds to phosphoinositides in the plasma membrane via its C-terminal region and probably functions as a membrane-bound transcription regulator that translocates to the nucleus in response to phosphoinositide hydrolysis, for instance, induced by G-protein-coupled-receptor signaling. It plays an important role in neuronal development and function. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, May 2009] (from NCBI)
Top mentioned proteins: TULP1, Shh, TUBE, Smo, THP
Papers on Tulp3
Modulation of Ciliary Phosphoinositide Content Regulates Trafficking and Sonic Hedgehog Signaling Output.
New
Schiffmann et al., Brussels, Belgium. In Dev Cell, Sep 2015
This is accompanied by recruitment of the PI(4,5)P2-interacting protein TULP3 to the ciliary membrane, along with Gpr161.
Computational analyses reveal a prognostic impact of TULP3 as a transcriptional master regulator in pancreatic ductal adenocarcinoma.
Moreira et al., Porto Alegre, Brazil. In Mol Biosyst, 2014
We identified Tubby-like protein 3 (TULP3) as a MR of transcription in PDAC samples.
Elution profile analysis of SDS-induced subcomplexes by quantitative mass spectrometry.
Boldt et al., Tübingen, Germany. In Mol Cell Proteomics, 2014
Furthermore, we identify the protein TULP3 as a potential new member of the IFT complex A and showed that several proteins, classified as IFT complex B-associated, are integral parts of this complex.
Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components.
Eggenschwiler et al., Princeton, United States. In Proc Natl Acad Sci U S A, 2011
Disruption of IFT122 leads to accumulation of Gli2 and Gli3 at cilia tips while blocking the ciliary localization of the antagonist TULP3.
Copy number variations and primary open-angle glaucoma.
Stone et al., Chicago, United States. In Invest Ophthalmol Vis Sci, 2010
This set included CNVs on 5q23.1 (DMXL1, DTWD2), 20p12 (PAK7), 12q14 (C12orf56, XPOT, TBK1, and RASSF3), 12p13.33 (TULP3), and 10q34.21
The tubby family proteins.
Review
Jackson et al., San Francisco, United States. In Genome Biol, 2010
Tulp1 is expressed in the retina and mutations in TULP1 cause retinitis pigmentosa in humans; Tulp3 is expressed ubiquitously in the mouse embryo and is important in sonic hedgehog (Shh)-mediated dorso-ventral patterning of the spinal cord.
TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia.
GeneRIF
Jackson et al., San Francisco, United States. In Genes Dev, 2010
Tubby-like protein 3 (TULP3) binds to the IFT-A complex
Tubby-like protein 3 (TULP3) regulates patterning in the mouse embryo through inhibition of Hedgehog signaling.
GeneRIF
Eggenschwiler et al., Princeton, United States. In Hum Mol Genet, 2009
TULP3 is required proper for Shh-dependent limb patterning.
Tulp3 is a critical repressor of mouse hedgehog signaling.
GeneRIF
Petkovich et al., Kingston, Canada. In Dev Dyn, 2009
This work uncovers a novel role for Tulp3 as a negative regulatory factor in the hedgehog pathway.
The tubby-like proteins, a family with roles in neuronal development and function.
Review
Naggert et al., Bar Harbor, United States. In J Cell Sci, 2002
Tub and the genes that encode three tubby-like proteins (TULP1- TULP3) form a novel, small gene family that plays an important role in maintenance and function of neuronal cells during development and post-differentiation.
Molecular cloning, expression and regulation of the avian tubby-like protein 1 (tulp1) gene.
Zenke et al., Berlin, Germany. In Gene, 2001
The tubby-like protein 1 (tulp1) gene is a member of the tubby multigene family which includes tub, tulp1, tulp2 and tulp3.
G-protein signaling through tubby proteins.
Impact
Shapiro et al., New York City, United States. In Science, 2001
The localization of tubby-like protein 3 (TULP3) is similarly regulated.
Neural tube defects and neuroepithelial cell death in Tulp3 knockout mice.
Naggert et al., Bar Harbor, United States. In Hum Mol Genet, 2001
The tubby-like protein 3 (Tulp3) gene has been identified as a member of a small novel gene family which is primarily neuronally expressed.
GFP-tagged expression and immunohistochemical studies to determine the subcellular localization of the tubby gene family members.
Naggert et al., Los Angeles, United States. In Brain Res Mol Brain Res, 2000
The tubby gene family consists of four members, TUB, TULP1, TULP2 and TULP3, with unknown function.
Molecular characterization of a novel tubby gene family member, TULP3, in mouse and humans.
Naggert et al., Los Angeles, United States. In Genomics, 1999
We describe here the isolation of the human and mouse homologs of a new family member, TULP3.
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