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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Ubiquitin associated and SH3 domain containing A

Tula, Sts-2
This gene encodes one of two family members belonging to the T-cell ubiquitin ligand (TULA) family. Both family members can negatively regulate T-cell signaling. This family member can facilitate growth factor withdrawal-induced apoptosis in T cells, which may occur via its interaction with AIF, an apoptosis-inducing factor. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011] (from NCBI)
Top mentioned proteins: Sts-2, ACID, V1a, CD45, OUT
Papers on Tula
Anti-miR-148a regulates platelet FcγRIIA signaling and decreases thrombosis in vivo in mice.
New
McKenzie et al., Philadelphia, United States. In Blood, Jan 2016
Using unbiased genome-wide expression profiling, we observed that human hyporesponders to FcγRIIA activation showed higher platelet T-cell ubiquitin ligand-2 (TULA-2) mRNA expression than hyperresponders.
Tula hantavirus infection in a hospitalised patient, France, June 2015.
New
Herti et al., Lyon, France. In Euro Surveill, Jan 2016
We report an infection with Tula virus in June 2015, leading to hospitalisation, in a patient living approximately 60 km east of Paris with no previous remarkable medical history.
Regulation of Early Steps of GPVI Signal Transduction by Phosphatases: A Systems Biology Approach.
New
Tindall et al., Reading, United Kingdom. In Plos Comput Biol, Nov 2015
Model revisions, incorporating a complex pathway of interactions (and specifically the phosphatase TULA-2), provided a good description of the experimental data both based on observations of phosphorylation in samples from one donor and in those of a wider population.
Protection from systemic Candida albicans infection by inactivation of the Sts phosphatases.
New
Carpino et al., Stony Brook, United States. In Infect Immun, Feb 2015
The suppressor of TCR signaling 1 (Sts-1) and Sts-2 are two homologous phosphatases that negatively regulate signaling pathways in a number of hematopoietic cell lineages, including T lymphocytes, mast cells, and platelets.
Adler hantavirus, a new genetic variant of Tula virus identified in Major's pine voles (Microtus majori) sampled in southern European Russia.
Klempa et al., Moscow, Russia. In Infect Genet Evol, 2015
Moreover, we found a single common vole (Microtusarvalis) infected with Tula virus (TULV).
Members of the novel UBASH3/STS/TULA family of cellular regulators suppress T-cell-driven inflammatory responses in vivo.
Tsygankov et al., Philadelphia, United States. In Immunol Cell Biol, 2014
The UBASH3/STS/TULA family consists of two members sharing substantial homology and a similar multi-domain architecture, which includes a C-terminal histidine phosphatase domain capable of dephosphorylating phosphotyrosine-containing substrates.
[Polymorphism of mitochondrial DNA in old believers from Siberia].
Voevoda et al., In Genetika, 2014
Statistically significant differences (P < 0.05) were revealed between the Old Believers examined and Bosnians, Czechs, Slovenes, and Russians from the cities of Nizhny Novgorod and Tula.
Enhanced response of T cells from murine gammaherpesvirus 68-infected mice lacking the suppressor of T cell receptor signaling molecules Sts-1 and Sts-2.
Krug et al., Stony Brook, United States. In Plos One, 2013
However, these alterations in the immune response and the overall absence of Sts-1 and Sts-2 did not impact viral pathogenesis or lead to pathology.
Hypoxia induces permeability and giant cell responses of Andes virus-infected pulmonary endothelial cells by activating the mTOR-S6K signaling pathway.
Mackow et al., Stony Brook, United States. In J Virol, 2013
In contrast to infection of cells with nonpathogenic Tula virus (TULV), we observed that exposure of ANDV-infected MECs and LECs to hypoxic conditions resulted in a 3- to 6-fold increase in monolayer permeability and the formation of giant cells 3× to 5× normal size.
Rational design of antigens to improve the serodiagnosis of tick-borne borreliosis in central regions of Russia.
Biketov et al., Moscow, Russia. In Adv Exp Med Biol, 2013
Thus, effort has been made to create a serological test using antigens from Moscow region, Tula and Ul'janovsk areas.
TULA-family proteins: a new class of cellular regulators.
Review
Tsygankov, Philadelphia, United States. In J Cell Physiol, 2013
Proteins of the UBASH3/STS/TULA family recently emerged as potent regulators of cellular functions.
Functional analysis and identification of cis-regulatory elements of human chromosome 21 gene promoters.
GeneRIF
Yaspo et al., Berlin, Germany. In Nucleic Acids Res, 2010
The UBASH3A promoter is activated by serum depletion according to promoter reporter assays in HEK 293 cells.
TULA-family proteins: an odd couple.
Review
Tsygankov, Philadelphia, United States. In Cell Mol Life Sci, 2009
Two members of the TULA family (TULA/STS-2/UBASH3A and TULA-2/STS-1/UBASH3B) recently emerged as novel regulators of several cellular functions.
TULA proteins regulate activity of the protein tyrosine kinase Syk.
GeneRIF
Tsygankov et al., Philadelphia, United States. In J Cell Biochem, 2008
TULA proteins TULA and TULA-2 regulate activity of the protein tyrosine kinase Syk
Multidomain STS/TULA proteins are novel cellular regulators.
Review
Tsygankov, Philadelphia, United States. In Iubmb Life, 2008
Proteins of the STS/TULA family recently emerged as important regulators of cellular functions.
TULA proteins bind to ABCE-1, a host factor of HIV-1 assembly, and inhibit HIV-1 biogenesis in a UBA-dependent fashion.
GeneRIF
Tsygankov et al., Philadelphia, United States. In Virology, 2008
Binds to ABCE-1 and inhibits HIV-1 life cycle, most likely by disrupting essential ubiquitylation-dependent events.
T-cell ubiquitin ligand affects cell death through a functional interaction with apoptosis-inducing factor, a key factor of caspase-independent apoptosis.
GeneRIF
Tsygankov et al., Philadelphia, United States. In J Biol Chem, 2007
TULA enhances the apoptotic effect of AIF by facilitating the interactions of AIF with its apoptotic co-factors
The Cbl-interacting protein TULA inhibits dynamin-dependent endocytosis.
GeneRIF
Madshus et al., Oslo, Norway. In Exp Cell Res, 2007
TULA inhibits both clathrin-dependent and clathrin-independent endocytic pathways by functionally sequestering dynamin via the SH3 domain of TULA binding proline-rich sequences in dynamin
[Prevalence of hantavirus infections in Germany].
Review
Koch et al., Berlin, Germany. In Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz, 2004
Neutralization assays detected almost exclusively human infections caused by Puumala and Dobrava viruses, only very rarely by Tula virus.
Regulation of ZAP-70 activation and TCR signaling by two related proteins, Sts-1 and Sts-2.
Impact
Ihle et al., Memphis, United States. In Immunity, 2004
Herein, we describe two related proteins, Sts-1 and Sts-2, that negatively regulate TCR signaling.
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