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Tubulin, gamma 1

TUBG1, GCP1
This gene encodes a member of the tubulin superfamily. The encoded protein localizes to the centrosome where it binds to microtubules as part of a complex referred to as the gamma-tubulin ring complex. The protein mediates microtubule nucleation and is required for microtubule formation and progression of the cell cycle. A pseudogene of this gene is found on chromosome 7. [provided by RefSeq, Jan 2009] (from NCBI)
Top mentioned proteins: gamma-tubulin, CAN, beta-4, Spc97p, GCP
Papers on TUBG1
Assessing associations between the AURKA-HMMR-TPX2-TUBG1 functional module and breast cancer risk in BRCA1/2 mutation carriers.
Pujana et al., l'Hospitalet de Llobregat, Spain. In Plos One, 2014
While interplay between BRCA1 and AURKA-RHAMM-TPX2-TUBG1 regulates mammary epithelial polarization, common genetic variation in HMMR (gene product RHAMM) may be associated with risk of breast cancer in BRCA1 mutation carriers.
The wide spectrum of tubulinopathies: what are the key features for the diagnosis?
Chelly et al., Paris, France. In Brain, 2014
Complex cortical malformations associated with mutations in tubulin genes: TUBA1A, TUBA8, TUBB2B, TUBB3, TUBB5 and TUBG1 commonly referred to as tubulinopathies, are a heterogeneous group of conditions with a wide spectrum of clinical severity.
Beta tubulin isoforms are not interchangeable for rescuing impaired radial migration due to Tubb3 knockdown.
Chelly et al., Paris, France. In Hum Mol Genet, 2014
Inputs from genetic studies were provided through the identification of several mutated genes encoding either proteins associated with microtubules (DCX, LIS1, KIF2A, KIF5C, DYNC1H1) or tubulin subunits (TUBA1A, TUBB2B, TUBB5 and TUBG1), in malformations of cortical development (MCD).
Fission yeast MOZART1/Mzt1 is an essential γ-tubulin complex component required for complex recruitment to the microtubule organizing center, but not its assembly.
Toda et al., Hiroshima, Japan. In Mol Biol Cell, 2013
γ-Tubulin functions as a multiprotein complex called the γ-tubulin complex (γ-TuC), consisting of GCP1-6 (GCP1 is γ-tubulin).
Mutations in TUBG1, DYNC1H1, KIF5C and KIF2A cause malformations of cortical development and microcephaly.
Impact
Chelly et al., Paris, France. In Nat Genet, 2013
Here we report the discovery of multiple pathogenic missense mutations in TUBG1, DYNC1H1 and KIF2A, as well as a single germline mosaic mutation in KIF5C, in subjects with MCD.
Clinical implication of centrosome amplification and expression of centrosomal functional genes in multiple myeloma.
Hajek et al., Brno, Czech Republic. In J Transl Med, 2012
Gene expression was significantly down-regulated in the CA positive group in comparison to CA negative in the following genes: AURKB, PLK4, TUBG1 (P < 0.05).
Chromosome painting reveals multiple rearrangements between Gymnotus capanema and Gymnotus carapo (Gymnotidae, Gymnotiformes).
Ferguson-Smith et al., Belém, Brazil. In Cytogenet Genome Res, 2012
From these 4, GCA6 and GCA20 correspond to individual chromosomes (GCP8 and GCP15), while the other 2 share homology with parts of GCP1 and GCP2, respectively.
Overexpression of γ-tubulin in non-small cell lung cancer.
GeneRIF
Katsetos et al., Philadelphia, United States. In Histol Histopathol, 2012
Our results reveal for the first time an increased expression of TUBG1 and TUBG2 in lung cancer
Nuclear γ-tubulin associates with nucleoli and interacts with tumor suppressor protein C53.
GeneRIF
Dráber et al., Czech Republic. In J Cell Physiol, 2012
in transformed as well as in non-transformed interphase mammalian cells gamma-tubulin is present not only in cytoplasm but also in nuclei and nucleoli where it can be translocated during mitosis
Feeding cells induced by phytoparasitic nematodes require γ-tubulin ring complex for microtubule reorganization.
de Almeida Engler et al., Antibes, France. In Plos Pathog, 2011
The transcripts of two Arabidopsis γ-tubulin (TUBG1 and TUBG2) and two γ-tubulin complex proteins genes (GCP3 and GCP4) are upregulated in galls.
Cdk1 and BRCA1 target γ-tubulin to microtubule domains.
GeneRIF
Gettemans et al., Gent, Belgium. In Biochem Biophys Res Commun, 2011
overexpression of Cdk1 or BRCA1 greatly expands the gamma-tubulin coating of microtubules, suggesting that the microtubule-bound gamma-tubulin is involved in DNA damage response.
CEP70 protein interacts with γ-tubulin to localize at the centrosome and is critical for mitotic spindle assembly.
GeneRIF
Zhou et al., Tianjin, China. In J Biol Chem, 2011
These results thus report for the first time the identification of Cep70 as an important centrosomal protein that interacts with gamma-tubulin and underscore its critical role in the regulation of mitotic spindle assembly.
γ-Tubulin localizes at actin-based membrane protrusions and inhibits formation of stress-fibers.
GeneRIF
Gettemans et al., Gent, Belgium. In Biochem Biophys Res Commun, 2011
The data presented here indicate that gamma-tubulin has a profound relationship with actin filament dynamics
Centrosome-related genes, genetic variation, and risk of breast cancer.
Couch et al., Rochester, United States. In Breast Cancer Res Treat, 2011
A two SNP combination of rs10145182 in NIN and rs2134808 in the TUBG1 locus (P-interaction = 0.00001), suggested SNPs in mediators of microtubule nucleation from the centrosome contribute to breast cancer.
Regulation of human adipose-derived stromal cell osteogenic differentiation by insulin-like growth factor-1 and platelet-derived growth factor-alpha.
Longaker et al., Stanford, United States. In Plast Reconstr Surg, 2010
Osteogenesis and adipogenesis were assessed by alkaline phosphatase, alizarin red, and oil red O staining, and quantitative real-time polymerase chain reaction (RUNX2, ALP, OCN, IGF1, PPARG, LPL, AP2, and GCP1).
Differential expression and cellular distribution of gamma-tubulin and betaIII-tubulin in medulloblastomas and human medulloblastoma cell lines.
Katsetos et al., Philadelphia, United States. In J Cell Physiol, 2010
By quantitative real-time PCR, gamma-tubulin transcripts for TUBG1, TUBG2, and TUBB3 genes were detected in both cell lines but expression was less prominent when compared with the human glioblastoma cell lines.
The environmental toxicant 2,3,7,8-tetrachlorodibenzo-p-dioxin disturbs the establishment and maintenance of cell polarity in preimplantation rat embryos.
Albertini et al., Kansas City, United States. In Biol Reprod, 2010
The subcellular localization of the centrosomal marker TUBG1 was analyzed in preimplantation embryos collected from female rats exposed to either chronic (50 ng kg(-1) wk(-1) for 3 wk) or acute (50 ng/kg or 1 microg/kg at proestrus) doses of TCDD.
Eukaryotic GCP1 is a conserved mitochondrial protein required for progression of embryo development beyond the globular stage in Arabidopsis thaliana.
Adamska et al., Hilden, Germany. In Biochem J, 2009
Our survey of genome databases revealed that all eukaryotic organisms contain two GCP genes [called GCP1 and GCP2/Kae1 (kinase-associated endopeptidase 1)], whereas prokaryotes have only one, either of the GCP1- (Bacteria) or the GCP2/Kae1- (Archaea) type.
Identifying concerted evolution and gene conversion in mammalian gene pairs lasting over 100 million years.
Scherer et al., Toronto, Canada. In Bmc Evol Biol, 2008
RESULTS: We identified three human gene pairs undergoing concerted evolution (BMP8A/B, DDX19A/B, and TUBG1/2).
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