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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Dynamin binding protein

Tuba, DNMBP
DNMBP belongs to the DBL (MIM 311030) family of guanine nucleotide exchange factors and plays a role in the regulation of cell junctions (Otani et al., 2006 [PubMed 17015620]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: Actin, Cdc42, GAPDH, Dynamin I, N-WASP
Papers on Tuba
The proline-rich region of glyceraldehyde-3-phosphate dehydrogenase from human sperm may bind SH3 domains, as revealed by a bioinformatic study of low-complexity protein segments.
New
Grynberg et al., Warsaw, Poland. In Mol Reprod Dev, Jan 2016
By conducting a large-scale sequence comparison on low-complexity sequences available in databases, we identified a strong similarity between the proline-rich motif from GAPDHS and the proline-rich sequence from Ena/vasodilator-stimulated phosphoprotein-like (EVL), which is known to bind an SH3 domain of dynamin-binding protein (DNMBP).
Differential expression of genes involved in Bengal macrothrombocytopenia (BMTCP).
New
Shetty et al., Mumbai, India. In Blood Cells Mol Dis, Dec 2015
Four genes i.e. myotubularin related protein 9 (MTMR9), iron responsive element binding protein 2 (IREB2), alpha tubulin(TUBA) and tyrosine kinase ligand (TKL) were found to be differentially expressed in patient platelets as compared to that of normal healthy controls which was further confirmed by quantitative RT PCR analysis.
The Shp2-induced epithelial disorganization defect is reversed by HDAC6 inhibition independent of Cdc42.
New
Chang et al., Taipei, Taiwan. In Nat Commun, Dec 2015
Here we show that oncogenic Shp2 dephosphorylates Tuba to decrease Cdc42 activation, leading to the abnormal multi-lumen formation of epithelial cells.
Endothelial RhoGEFs: A systematic analysis of their expression profiles in VEGF-stimulated and tumor endothelial cells.
New
Vázquez-Prado et al., Mexico. In Vascul Pharmacol, Nov 2015
Among them, we found that the most abundant endothelial RhoGEFs were: Tuba, FGD5, Farp1, ARHGEF17, TRIO, P-Rex1, ARHGEF15, ARHGEF11, ABR, Farp2, ARHGEF40, ALS, DOCK1, DOCK7 and DOCK6.
Phosphorylation-dependent inhibition of Cdc42 GEF Gef1 by 14-3-3 protein Rad24 spatially regulates Cdc42 GTPase activity and oscillatory dynamics during cell morphogenesis.
New
Verde et al., Miami, United States. In Mol Biol Cell, Nov 2015
Our findings show how the 14-3-3 protein Rad24 modulates the availability of Cdc42 GEF Gef1, a homologue of mammalian Cdc42 GEF DNMBP/TUBA, to spatially control Cdc42 GTPase activity and promote cell polarization and cell shape emergence.
Transcription Factor Brn-3b Overexpression Enhances Neurite Outgrowth in PC12 Cells Under Condition of Hypoxia.
New
Krishnamoorthy et al., Fort Worth, United States. In Cell Mol Neurobiol, Aug 2015
Immunoblot analysis showed that overexpression of Brn-3b in PC12 cells as well as 661W cells produced significant increase in the growth cone marker, growth-associated protein-43 (GAP-43), and acetylated-tubulin (ac-TUBA).
Host endoplasmic reticulum COPII proteins control cell-to-cell spread of the bacterial pathogen Listeria monocytogenes.
New
Ireton et al., Dunedin, New Zealand. In Cell Microbiol, Jun 2015
In cultured enterocytes, the secreted Listeria protein InlC promotes protrusion formation by binding and inhibiting the human scaffolding protein Tuba.
Neuroprotective effects of transcription factor Brn3b in an ocular hypertension rat model of glaucoma.
New
Krishnamoorthy et al., Fort Worth, United States. In Invest Ophthalmol Vis Sci, Feb 2015
RESULTS: Adeno-associated virus-mediated expression of the Brn3b protein in IOP-elevated rat eyes promoted an upregulation of growth associated protein-43 (GAP-43), actin binding LIM protein (abLIM) and acetylated α-tubulin (ac-Tuba) both posterior to the ONH and in RGCs.
Evaluation and Selection of Appropriate Reference Genes for Real-Time Quantitative PCR Analysis of Gene Expression in Nile Tilapia (Oreochromis niloticus) during Vaccination and Infection.
Lai et al., Chengdu, China. In Int J Mol Sci, 2014
Among them, EF1A was the most stable reference with RefFinder, followed by 18S rRNA, ACTB, UBCE, TUBA and GAPDH respectively and the optimal number of reference genes for IgM normalization under different experiment sets was two with GeNorm.
Genetic association of CUGBP2 and DNMBP with Alzheimer' s disease in the Chinese Han population.
Wu et al., Hangzhou, China. In Curr Alzheimer Res, 2014
OBJECTIVE: Recently, candidate genetic studies revealed the single nucleotide polymorphisms (SNPs) of CUGBP2 (rs2242451) and DNMBP (rs11190305 and rs3740058) associated with Alzheimer's disease (AD).
Discoidin domain receptor 1 controls linear invadosome formation via a Cdc42-Tuba pathway.
Saltel et al., Bordeaux, France. In J Cell Biol, 2014
Cdc42 and its specific guanine nucleotide-exchange factor (GEF), Tuba, localize to linear invadosomes, and both are required for linear invadosome formation.
Role of host GTPases in infection by Listeria monocytogenes.
Review
Dowd et al., Dunedin, New Zealand. In Cell Microbiol, 2014
The human GTPase Cdc42, its activator Tuba, and its effector N-WASP form a complex with the potential to restrict Listeria protrusions.
Molecular mechanism of protrusion formation during cell-to-cell spread of Listeria.
Review
Schubert et al., Dunedin, New Zealand. In Front Cell Infect Microbiol, 2013
Recent results indicate that formation of Listeria protrusions in polarized human cells involves bacterial antagonism of a host signaling pathway comprised of the scaffolding protein Tuba and its effectors N-WASP and Cdc42.
Tuba and N-WASP function cooperatively to position the central lumen during epithelial cyst morphogenesis.
GeneRIF
Yap et al., Australia. In Cell Adh Migr, 2011
Polyproline region of N-WASP is required for the localization of Tuba at the pre-apical patch.
A molecular network for de novo generation of the apical surface and lumen.
Impact
Mostov et al., San Francisco, United States. In Nat Cell Biol, 2010
Rab8a and Rab11a function through the exocyst to target Par3 to the apical surface, and control apical Cdc42 activation through the Cdc42 GEF, Tuba.
DNMBP is genetically associated with Alzheimer dementia in the Belgian population.
GeneRIF
Van Broeckhoven et al., Antwerp, Belgium. In Neurobiol Aging, 2009
findings underscore a role for DNMBP in the genetic risk for late-onset Alzheimer's disease in the Belgian population
The bacterial virulence factor InlC perturbs apical cell junctions and promotes cell-to-cell spread of Listeria.
Impact
Ireton et al., Toronto, Canada. In Nat Cell Biol, 2009
We next identify the mammalian adaptor protein Tuba as a ligand of InlC.
Association analysis of dynamin-binding protein (DNMBP) on chromosome 10q with late onset Alzheimer's disease in a large caucasian UK sample.
GeneRIF
Williams et al., Cardiff, United Kingdom. In Am J Med Genet B Neuropsychiatr Genet, 2009
Although DNMBP is an excellent candidate gene because of its role in the APP recycling pathways and being located within a chromosome 10 linkage region, we are unable to confirm that DNMBP is associated with LOAD
No association of dynamin binding protein (DNMBP) gene SNPs and Alzheimer's disease.
GeneRIF
Kamboh et al., Pittsburgh, United States. In Neurobiol Aging, 2008
We observed no association of statistical significance in either the total sample or the APOE*4 non-carriers for any of the SNPs of Dynamin Binding Protein.
Cdc42 GEF Tuba regulates the junctional configuration of simple epithelial cells.
GeneRIF
Takeichi et al., Kyoto, Japan. In J Cell Biol, 2006
Tuba controls the shaping of cell junctions through the local activation of Cdc42 and its effectors.
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