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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Ras homolog gene family, member H

TTF, RhoH
The protein encoded by this gene is a member of the Ras superfamily of small GTPases. Expression of a chimeric transcript of LAZ3 and this gene has been reported as a result of the translocation t(3;4) in non-Hodgkin's lymphomas. This gene encodes a small G-like protein, and unlike most other small G proteins which are expressed ubiquitously, this gene is transcribed only in hemopoietic cells. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: TTF-1, CAN, HAD, cytokeratin, EGFR
Papers on TTF
Functional characterization of two novel mutations in TTF-1/NKX2.1 homeodomain in patients with benign hereditary chorea.
New
Civitareale et al., Monterotondo, Italy. In J Neurol Sci, Feb 2016
The thyroid transcription factor 1 (TTF-1) is encoded, on chromosome 14q13, by the gene termed TITF-1/NKX2.1.
Peritoneal malignant mesothelioma (PMM), and primary peritoneal serous carcinoma (PPSC) and reactive mesothelial hyperplasia (RMH) of the peritoneum. Immunohistochemical and fluorescence in situ hybridisation (FISH) analyses.
New
Hiroshima et al., Tokorozawa, Japan. In J Clin Pathol, Feb 2016
METHODS: To help differentiate PMM from PPSC and RMH, we used immunohistochemistry to examine mesothelial-associated markers (calretinin, AE1/AE3, CK5/6, CAM5.2, D2-40, WT-1, HBME1, thrombomodulin), adenocarcinoma-associated markers (CEA, BerEP4, MOC31, ER (estrogen receptor), PgR, TTF-1, Claudin-4, Pax8), and malignant-related and benign-related markers (epithelial membrane antigen (EMA), desmin, GLUT-1, CD146 and IMP3), and FISH to examine for homozygous deletion of 9p21.
Comparison of immunohistochemistry and mRNA in situ hybridization in detecting thyroid transcription factor-1 expression in non-small cell lung carcinomas tissue.
New
Zhang et al., Shenyang, China. In Oncol Lett, Dec 2015
UNASSIGNED: Thyroid transcription factor-1 (TTF-1) reportedly possesses oncogenic and suppressive roles within the same tumor type and may play a dual function in the progression of lung cancer.
ROR1 sustains caveolae and survival signalling as a scaffold of cavin-1 and caveolin-1.
New
Takahashi et al., Nagoya, Japan. In Nat Commun, Dec 2015
The receptor tyrosine kinase-like orphan receptor 1 (ROR1) sustains prosurvival signalling directly downstream of the lineage-survival oncogene NKX2-1/TTF-1 in lung adenocarcinoma.
Mucinous Variant of Follicular Carcinoma of the Thyroid Gland: Case Report and Review of the Literature.
Review
New
Cosimi et al., Novi Ligure, Italy. In Int J Surg Pathol, Dec 2015
We report the fourth case of mucinous variant of follicular carcinoma displaying a minimally invasive tumor with diffuse expression of thyroglobulin, TTF-1, CD56, PAX-8, cytokeratins 7 and 19, in the absence of monoclonal carcinoembryonic antigen (CEA), cytokeratin 20, chromogranin, HBME-1, P63 expression, and BRAF gene mutation, in a 51-year-old woman who is alive without signs of disease 13 months after total thyroidectomy, bilateral neck dissection, and radioactive iodine.
Thyroid-like follicular carcinoma of the kidney: one case report and review of the literature.
Review
New
Nodit et al., Pittsburgh, United States. In Am J Clin Pathol, Nov 2015
Our goal is to expand the knowledge of this rare renal cell carcinoma subtype, which is morphologically similar to follicular carcinoma of the thyroid but lacks expression of characteristic thyroid immunohistochemical markers such as TTF-1 and thyroglobulin.
Design and Synthesis of Nonequilibrium Systems.
Review
New
Astumian et al., Evanston, United States. In Acs Nano, Oct 2015
The launching pad is a bistable [2]rotaxane whose dumbbell component contains two electron-donating recognition sites, one, a tetrathiafulvalene (TTF) unit, which interacts more strongly with the ring component, cyclobis(paraquat-p-phenylene) (CBPQT(4+)), containing two electron-accepting bipyridinium units, than does the other 1,5-dioxynaphthalene (DNP) unit.
Phase III trial evaluating the addition of bevacizumab to endocrine therapy as first-line treatment for advanced breast cancer: the letrozole/fulvestrant and avastin (LEA) study.
New
Impact
De la Haba-Rodriguez et al., A Coruña, Spain. In J Clin Oncol, Apr 2015
We compared progression-free survival (PFS), overall survival (OS), overall response rate (ORR), response duration (RD), time to treatment failure (TTF), clinical benefit rate (CBR), and safety.
Infant pleuropulmonary blastoma: report of a rare case and review of literature.
Wang et al., Beijing, China. In Int J Clin Exp Pathol, 2014
Immunohistochemistry was performed for further detection: vimentin (+), S-100 protein (+), CK (AE1/AE3), EMA and TTF-1 in residual epithelial components (+), NSE (focal +), SMA (mesenchymal cells, focal +), CD99 (weak +), Bcl-2 (weak +), desmin (-), myoglobin (-), calretinin (-), calponin (-), FLI (-), MyoD-1 (-), and CD34 (-).
A rare case of pulmonary sclerosing hemagioma with lymph node metastasis and review of the literature.
Review
Zhang et al., Hangzhou, China. In Int J Clin Exp Pathol, 2014
Immunohistochemistry (IHC) revealed that both surface-lining cuboidal and polygonal cells expressed EMA and thyroid transcription factor 1 (TTF-1), but were negative for CD34, VIII factor, CD68 and Claratinin.
Star-shaped tetrathiafulvalene oligomers towards the construction of conducting supramolecular assembly.
Review
Hasegawa et al., Hachiōji, Japan. In Beilstein J Org Chem, 2014
The construction of redox-active supramolecular assemblies based on star-shaped and radially expanded tetrathiafulvalene (TTF) oligomers with divergent and extended conjugation is summarized.
NKX2-1/TTF-1: an enigmatic oncogene that functions as a double-edged sword for cancer cell survival and progression.
Review
Impact
Takahashi et al., Nagoya, Japan. In Cancer Cell, 2013
Emerging evidence indicates that NKX2-1, a homeobox-containing transcription factor also known as TTF-1, plays a role as a "lineage-survival" oncogene in lung adenocarcinomas.
Human RHOH deficiency causes T cell defects and susceptibility to EV-HPV infections.
GeneRIF
Jouanguy et al., New York City, United States. In J Clin Invest, 2012
RHOH deficiency leads to T cell defects and persistent epidermodysplasia verruciformis-HPV infections.
Opposing roles for RhoH GTPase during T-cell migration and activation.
GeneRIF
Kim et al., Rochester, United States. In Proc Natl Acad Sci U S A, 2012
conclude that RhoH expression provides a key molecular determinant that allows T cells to switch between sensing chemokine-mediated go signals and TCR-dependent stop signals
RhoH is critical for cell-microenvironment interactions in chronic lymphocytic leukemia in mice and humans.
GeneRIF
Williams et al., Boston, United States. In Blood, 2012
RhoH plays a critical role in prosurvival chronic lymphocytic leukemia cell-cell and cell-microenvironment interactions with this agent.
NKX2-1/TITF1/TTF-1-Induced ROR1 is required to sustain EGFR survival signaling in lung adenocarcinoma.
Impact
Takahashi et al., Nagoya, Japan. In Cancer Cell, 2012
We and others previously identified NKX2-1, also known as TITF1 and TTF-1, as a lineage-survival oncogene in lung adenocarcinomas.
Repression of the RHOH gene by JunD.
GeneRIF
Shelley et al., Lille, France. In Biochem J, 2011
Repression of the RHOH gene by JunD
Rhoh deficiency reduces peripheral T-cell function and attenuates allogenic transplant rejection.
GeneRIF
Gröne et al., Heidelberg, Germany. In Eur J Immunol, 2011
These findings stress the importance of Rhoh for the function of peripheral T cells.
Ion-mediated electron transfer in a supramolecular donor-acceptor ensemble.
Impact
Sessler et al., Austin, United States. In Science, 2010
We report here that strong binding of specific anions (chloride, bromide, and methylsulfate but not tetrafluoroborate or hexafluorophosphate) to a tetrathiafulvalene calix[4]pyrrole (TTF-C4P) donor enforces a host conformation that favors electron transfer to a bisimidazolium quinone (BIQ2+) guest acceptor.
NOA-04 randomized phase III trial of sequential radiochemotherapy of anaplastic glioma with procarbazine, lomustine, and vincristine or temozolomide.
Impact
Weller et al., Tübingen, Germany. In J Clin Oncol, 2010
The primary end point was time to treatment failure (TTF), defined as progression after radiotherapy and one chemotherapy in either sequence.
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