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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Forkhead box E1

TTF-2, FOXE1, Titf2
This intronless gene belongs to the forkhead family of transcription factors, which is characterized by a distinct forkhead domain. This gene functions as a thyroid transcription factor which likely plays a crucial role in thyroid morphogenesis. Mutations in this gene are associated with congenital hypothyroidism and cleft palate with thyroid dysgenesis. The map localization of this gene suggests it may also be a candidate gene for squamous cell epithelioma and hereditary sensory neuropathy type I. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: TTF, PAX8, TTF-1, thyroglobulin, CAN
Papers on TTF-2
Nitric oxide-repressed Forkhead factor FoxE1 expression is involved in the inhibition of TSH-induced thyroid peroxidase levels.
New
Masini-Repiso et al., Córdoba, Argentina. In Mol Cell Endocrinol, Feb 2016
Moreover, we characterized the FoxE1 binding site Z as mediator of the NO-inhibited TPO expression.
FOXE1 polymorphisms and non-syndromic orofacial clefts susceptibility in a Chinese Han population.
New
Pan et al., Nanjing, China. In Oral Dis, Feb 2016
OBJECTIVE: FOXE1 plays an important role in craniofacial development.
Development of new quantitative mass spectrometry and semi-automatic isofocusing methods for the determination of Apolipoprotein E typing.
New
Lehmann et al., Montpellier, France. In Clin Chim Acta, Jan 2016
Then, incubation of the gel with HRP secondary antibody followed by TTF1/TTF2 substrate allowed the visualization of ApoE bands.
Identification and functional analysis of novel facial patterning genes in the duplicated beak chicken embryo.
New
Richman et al., Vancouver, Canada. In Dev Biol, Dec 2015
Expression of TP63, TBX22, BMP4 and FOXE1, all human clefting genes, were upregulated.
Gene expression of thyroid-specific transcription factors may help diagnose thyroid lesions but are not determinants of tumor progression.
New
Assumpção et al., Campinas, Brazil. In J Endocrinol Invest, Oct 2015
METHODS: We quantified TTF-1, FOXE1 and PAX8 mRNA levels, relating their expression to diagnostic and prognostic features of thyroid tumors.
Heterogeneous phenotype in children affected by non-autoimmune hypothyroidism: an update.
Review
New
Weber et al., Milano, Italy. In J Endocrinol Invest, Aug 2015
Finally, an increased prevalence of hypothyroidism has been documented in obese children and patients with syndromic forms (Williams, Down, Turner, pseudohypoparathyroidism). The clinical and molecular phenotype of patients with CH will be better defined thanks to novel genetic approach based on the systematic analysis of a panel of genes (TSHR, DUOX2, DUOXA, TPO, PDS, TG, NKX2.1, JAG1, GLIS3, FOXE1, PAX-8).
Thyroid transcription factors in development, differentiation and disease.
Review
Santisteban et al., Madrid, Spain. In Nat Rev Endocrinol, 2015
Identification of the thyroid transcription factors (TTFs), NKX2-1, FOXE1, PAX8 and HHEX, has considerably advanced our understanding of thyroid development, congenital thyroid disorders and thyroid cancer.
Genetic Defects in Thyroid Hormone Supply
Review
Macchia et al., Madagascar. In Unknown Journal, 2015
Several genes have been associated to TD, including PAX8, NKX2-5, FOXE1, NKX2-5 and TSH-receptor genes.
The investigation of foxe1 variations in papillary thyroid carcinoma.
Kapan et al., Erzincan, Turkey. In Int J Clin Exp Pathol, 2014
The aim of our study was to determine a possible relationship between Forkhead box E1 (FOXE1) gene variants and histopathological features of papillary thyroid carcinoma.
Clinical genetics of congenital hypothyroidism.
Review
Szinnai, Basel, Switzerland. In Endocr Dev, 2013
Five monogenetic forms due to mutations in TSHR, PAX8, NKX2-1, FOXE1 and NKX2-5 have been identified so far.
The molecular causes of thyroid dysgenesis: a systematic review.
Review
Macchia et al., Napoli, Italy. In J Endocrinol Invest, 2013
In these cases, mutations in genes playing a role during thyroid morphogenesis (NKX2-1, PAX8, FOXE1, NKX2-5, TSHR) have been reported.
Association of candidate genes with nonsyndromic clefts in Honduran and Colombian populations.
GeneRIF
Haddad et al., New York City, United States. In Laryngoscope, 2012
FOXE1 genes suggest a role for orofacial clefting in hispanic polulation.
Suppression of estrogen receptor-alpha transactivation by thyroid transcription factor-2 in breast cancer cells.
GeneRIF
Lee et al., Kwangju, South Korea. In Biochem Biophys Res Commun, 2012
these data suggest that TTF-2 may modulate the function of ERalpha as a corepressor and play a role in ER-dependent proliferation of mammary cells.
Novel associations for hypothyroidism include known autoimmune risk loci.
GeneRIF
Do et al., Mountain View, United States. In Plos One, 2011
Novel associations for hypothyroidism and autoimmune risk loci include SNPs near the FOXE1 gene.
FOXE1 polyalanine tract length screening by MLPA in idiopathic premature ovarian failure.
GeneRIF
Xie et al., Shenzhen, China. In Reprod Biol Endocrinol, 2010
Polyalanine repeat expansions in FOXE1 is associated with the genetic aetiology of POF in Chinese women.
Genetic investigation of FOXE1 polyalanine tract in thyroid diseases: new insight on the role of FOXE1 in thyroid carcinoma.
GeneRIF
Hadj Kacem et al., Sfax, Tunisia. In Cancer Biomark, 2009
these results excluded the association of poly (Ala) polymorphism with autoimmune thyroid diseases; however it confirms the involvement of FOXE1 in the genesis of thyroid carcinoma.
SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas.
Impact
Meyerson et al., In Nat Genet, 2009
Furthermore, ectopic expression of SOX2 here cooperated with FOXE1 or FGFR2 to transform immortalized tracheobronchial epithelial cells.
Common variants on 9q22.33 and 14q13.3 predispose to thyroid cancer in European populations.
Impact
Stefansson et al., Reykjavík, Iceland. In Nat Genet, 2009
The gene nearest to the 9q22.33 locus is FOXE1 (TTF2) and NKX2-1 (TTF1) is among the genes located at the 14q13.3
Mutation of the gene encoding human TTF-2 associated with thyroid agenesis, cleft palate and choanal atresia.
Impact
Chatterjee et al., Cambridge, United Kingdom. In Nat Genet, 1998
11) is the human homologue of mouse TTF-2 (encoded by the Titf2 gene) and that two siblings with thyroid agenesis, cleft palate and choanal atresia are homozygous for a missense mutation (Ala65Val) within its forkhead domain.
A mouse model for hereditary thyroid dysgenesis and cleft palate.
Impact
Di Lauro et al., Napoli, Italy. In Nat Genet, 1998
We have recently cloned cDNA encoding a forkhead domain-containing transcription factor, TTF-2, and have located the position of the gene, designated Titf2, to mouse chromosome 4 (ref.
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