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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

NK2 homeobox 1

TTF-1, thyroid transcription factor-1, Nkx2.1
This gene encodes a protein initially identified as a thyroid-specific transcription factor. The encoded protein binds to the thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the expression of genes involved in morphogenesis. Mutations and deletions in this gene are associated with benign hereditary chorea, choreoathetosis, congenital hypothyroidism, and neonatal respiratory distress, and may be associated with thyroid cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares the symbol/alias 'TFF1' with another gene, transcription termination factor 1, which plays a role in ribosomal gene transcription. [provided by RefSeq, Apr 2011] (from NCBI)
Top mentioned proteins: TTF, cytokeratin, HAD, CAN, p63
Papers using TTF-1 antibodies
Differential diagnosis of primary versus metastatic pulmonary adenocarcinomas using gene mutation analyses: a case report
Supplier
Allan Robert W. et al., In Case Reports in Pathology, 2007
These included thyroid transcription factor-1 (TTF-1, 8G7G3/1 clone, Cell Marque, Rocklin, CA, USA), cytokeratin ...
Features of benign granular cell tumor on fine needle aspiration
Supplier
Jhala Darshana N et al., In CytoJournal, 1998
... detect the following antibodies: S-100 (Ventana; predilute), CD68 (Ventana; predilute), thyroglobulin (Cell marque; predilute), and TTF-1 (Dako; 1:50) ...
Association of arsenic-induced malignant transformation with DNA hypomethylation and aberrant gene expression.
Supplier
Yang Chengfeng et al., In Environmental Health Perspectives, 1996
... Anti-thyroid transcription factor 1 (anti-TTF-1; sc-13040) primary antibody was obtained from Santa Cruz Biotechnology.
Architecture of the human lung. Use of quantitative methods establishes fundamental relations between size and number of lung structures
Supplier
Snyder Brian D. et al., In Clinical Orthopaedics and Related Research, 1961
... TTF-1Type II pneumocytesDAKO, Carpinteria, CA (M3575) ...
Papers on TTF-1
Peritoneal malignant mesothelioma (PMM), and primary peritoneal serous carcinoma (PPSC) and reactive mesothelial hyperplasia (RMH) of the peritoneum. Immunohistochemical and fluorescence in situ hybridisation (FISH) analyses.
New
Hiroshima et al., Tokorozawa, Japan. In J Clin Pathol, Feb 2016
METHODS: To help differentiate PMM from PPSC and RMH, we used immunohistochemistry to examine mesothelial-associated markers (calretinin, AE1/AE3, CK5/6, CAM5.2, D2-40, WT-1, HBME1, thrombomodulin), adenocarcinoma-associated markers (CEA, BerEP4, MOC31, ER (estrogen receptor), PgR, TTF-1, Claudin-4, Pax8), and malignant-related and benign-related markers (epithelial membrane antigen (EMA), desmin, GLUT-1, CD146 and IMP3), and FISH to examine for homozygous deletion of 9p21.
Small Cell Carcinoma of the Urinary Bladder: KIT and PDGFRA Gene Mutations.
New
Kozacioğlu et al., İzmir, Turkey. In Rare Tumors, Jan 2016
The tumor cells were negative for CK7, CK20, CD3, CD20, LCA, CDX2, uroplakin, thyroid transcription factor 1, PSA and p63.
[Bilateral Pneumothorax due to Pulmonary Metastasis from Angiosarcoma of the Forehead;Report of a Case].
New
Yamamoto et al., Itami, Japan. In Kyobu Geka, Dec 2015
These cells were cluster differentiation(CD)31 and CD34 positive and negative for calretinin, cytokeratin, carcinoembryonic antigen (CEA), thyroid transcription factor(TTF-1)and epithelial membrane antigen(EMA).
Comparison of immunohistochemistry and mRNA in situ hybridization in detecting thyroid transcription factor-1 expression in non-small cell lung carcinomas tissue.
New
Zhang et al., Shenyang, China. In Oncol Lett, Dec 2015
UNASSIGNED: Thyroid transcription factor-1 (TTF-1) reportedly possesses oncogenic and suppressive roles within the same tumor type and may play a dual function in the progression of lung cancer.
Thyroid-like follicular carcinoma of the kidney: one case report and review of the literature.
Review
New
Nodit et al., Pittsburgh, United States. In Am J Clin Pathol, Nov 2015
Our goal is to expand the knowledge of this rare renal cell carcinoma subtype, which is morphologically similar to follicular carcinoma of the thyroid but lacks expression of characteristic thyroid immunohistochemical markers such as TTF-1 and thyroglobulin.
Thyroid Paraganglioma.
Review
New
Policarpio-Nicolas et al., San Antonio, United States. In Arch Pathol Lab Med, Aug 2015
Immunohistochemical stains (cytokeratin, parathyroid hormone, thyroid transcription factor 1, tyrosine hydroxylase, chromogranin A, synaptophysin, S100, calcitonin, carcinoembryonic antigen) are essential in establishing the diagnosis.
Cutaneous metastases from gastric adenocarcinoma 15 years after curative gastrectomy.
Review
New
Sang et al., Nanjing, China. In An Bras Dermatol, May 2015
They were stained positive for villin, CDX-2, CKpan (AE1/ AE3), CEA, CK8/18, CK19, CK7, EMA, Ki-67 (50%), and negative for S-100, CK20, CD34, GCDFP-15 and TTF-1.
A rare case of pulmonary sclerosing hemagioma with lymph node metastasis and review of the literature.
Review
Zhang et al., Hangzhou, China. In Int J Clin Exp Pathol, 2014
Immunohistochemistry (IHC) revealed that both surface-lining cuboidal and polygonal cells expressed EMA and thyroid transcription factor 1 (TTF-1), but were negative for CD34, VIII factor, CD68 and Claratinin.
Benign Hereditary Chorea: An Update.
Review
Kurian et al., London, United Kingdom. In Tremor Other Hyperkinet Mov (n Y), 2014
The disorder is caused by mutations to the NKX2.1 (TITF1) gene and also forms part of the "brain-lung-thyroid syndrome", in which additional developmental abnormalities of lung and thyroid tissue are observed.
Numerous osteoclast-like giant cells in metastases from lung adenocarcinoma, but absent from primary tumor.
Sato et al., Tokyo, Japan. In Thorac Cancer, 2014
Primary lung carcinoma cells were positive for cytokeratin 7 (CK7), epithelial membrane antigen (EMA), thyroid transcription factor 1 (TTF-1), and Napsin A, but were negative for vimentin and CD68.
Maintenance therapy for advanced lung cancer: who, what, and when?
Impact
Gerber, Dallas, United States. In J Clin Oncol, 2013
Immunohistochemical stains were positive for napsin A and thyroid transcription factor 1, suggestive of adenocarcinoma (Fig 1).
NKX2-1/TTF-1: an enigmatic oncogene that functions as a double-edged sword for cancer cell survival and progression.
Review
Impact
Takahashi et al., Nagoya, Japan. In Cancer Cell, 2013
Emerging evidence indicates that NKX2-1, a homeobox-containing transcription factor also known as TTF-1, plays a role as a "lineage-survival" oncogene in lung adenocarcinomas.
Directed differentiation and functional maturation of cortical interneurons from human embryonic stem cells.
Impact
Studer et al., New York City, United States. In Cell Stem Cell, 2013
Here, we demonstrate the highly efficient derivation of human cortical interneurons in an NKX2.1::GFP human embryonic stem cell reporter line.
Medial ganglionic eminence-like cells derived from human embryonic stem cells correct learning and memory deficits.
Impact
Zhang et al., Madison, United States. In Nat Biotechnol, 2013
Here we present a method for differentiating human embryonic stem cells (hESCs) to a nearly uniform population of NKX2.1(+)
Occludin is a direct target of thyroid transcription factor-1 (TTF-1/NKX2-1).
GeneRIF
Mu et al., United States. In J Biol Chem, 2012
TTF-1 transcriptionally regulates occludin, which represents another avenue of TTF-1-mediated metastasis suppression
Thyroid transcription factor 1, a homeodomain containing transcription factor, contributes to regulating periodic oscillations in GnRH gene expression.
GeneRIF
Ojeda et al., Beaverton, United States. In J Neuroendocrinol, 2012
TTF1 contributes to regulating periodic oscillations in expression of the gonadotrophin-releasing hormone (GnRH) gene expression; TTF1 transactivates GnRH transcription by binding to two sites in the GnRH promoter.
Opposite roles of FOXA1 and NKX2-1 in lung cancer progression.
GeneRIF
Wikman et al., Hamburg, Germany. In Genes Chromosomes Cancer, 2012
Assessed gene amplifications and protein expression of NKX2-1 and FOXA1 in primary lung tumors (n = 554) and brain metastases (n = 68).
Generation of multipotent lung and airway progenitors from mouse ESCs and patient-specific cystic fibrosis iPSCs.
Impact
Rajagopal et al., Boston, United States. In Cell Stem Cell, 2012
Definitive endoderm derived from mouse embryonic stem cells (ESCs) was converted into foregut endoderm, then into replicating Nkx2.1+ lung endoderm, and finally into multipotent embryonic lung progenitor and airway progenitor cells.
NKX2-1/TITF1/TTF-1-Induced ROR1 is required to sustain EGFR survival signaling in lung adenocarcinoma.
Impact
GeneRIF
Takahashi et al., Nagoya, Japan. In Cancer Cell, 2012
NKX2-1 induces the expression of the receptor tyrosine kinase-like orphan receptor 1 (ROR1), which in turn sustains a favorable balance between prosurvival PI3K-AKT and pro-apoptotic p38 signaling.
Genome-wide analyses of Nkx2-1 binding to transcriptional target genes uncover novel regulatory patterns conserved in lung development and tumors.
GeneRIF
Ramirez et al., Boston, United States. In Plos One, 2011
Expression levels of Nkx2-1 direct target genes identified in mouse development significantly correlate or anti-correlate to the levels of endogenous NKX2-1 in a dosage-dependent manner in multiple human lung tumor expression data sets.
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