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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Thrombospondin 2

TSP2, thrombospondin-2, THBS2
The protein encoded by this gene belongs to the thrombospondin family. It is a disulfide-linked homotrimeric glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein has been shown to function as a potent inhibitor of tumor growth and angiogenesis. Studies of the mouse counterpart suggest that this protein may modulate the cell surface properties of mesenchymal cells and be involved in cell adhesion and migration. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: thrombospondin-1, CAN, HAD, vascular endothelial growth factor, V1a
Papers on TSP2
Mesenchymal Cancer Cell-Stroma Crosstalk Promotes Niche Activation, Epithelial Reversion, and Metastatic Colonization.
New
Malanchi et al., London, United Kingdom. In Cell Rep, Jan 2016
Here, we found that metastatic initiating cells (MICs) exhibit a high capacity for lung fibroblast activation as a result of Thrombospondin 2 (THBS2) expression.
Adolescent Intermittent Alcohol Exposure: Dysregulation of Thrombospondins and Synapse Formation are Associated with Decreased Neuronal Density in the Adult Hippocampus.
New
Swartzwelder et al., Durham, United States. In Alcohol Clin Exp Res, Dec 2015
By the 10th dose, increased TSP2 levels were accompanied by an increase in colocalized pre- and postsynaptic puncta, while α2δ-1 returned to control levels.
Expression of genes involved in cellular adhesion and ECM-remodelling correlates with poor survival of renal cancer patients.
New
Piekielko-Witkowska et al., Warsaw, Poland. In J Urol, Dec 2015
The 10-gene expression signature (COL1A1, COL5A1, COL11A1, FN1, ICAM1, ITGAL, ITGAM, ITGB2, THBS2, and TIMP1) correlated with poor survival (HR=2.85,
Human Umbilical Tissue-Derived Cells Promote Synapse Formation and Neurite Outgrowth via Thrombospondin Family Proteins.
New
Eroglu et al., Durham, United States. In J Neurosci, Dec 2015
Furthermore, through biochemical fractionation and pharmacology, we identified the major hUTC-secreted synaptogenic factors as the thrombospondin family proteins (TSPs), TSP1, TSP2, and TSP4.
Human umbilical tissue-derived cells rescue retinal pigment epithelium dysfunction in retinal degeneration.
New
Inana et al., United States. In Stem Cells, Dec 2015
hUTC secrete receptor tyrosine kinase (RTK) ligands brain-derived neurotrophic factor (BDNF), hepatocyte growth factor (HGF), and glial cell-derived neurotrophic factor (GDNF), as well as opsonizing bridge molecules milk-fat-globule-epidermal growth factor 8 (MFG-E8), growth arrest-specific 6 (Gas6), thrombospondin (TSP)-1, and TSP-2.
Reduced Supply of Monocyte-Derived Macrophages Leads to a Transition from Nodular to Diffuse Lesions and Tissue Cell Activation in Silica-Induced Pulmonary Fibrosis in Mice.
New
Matsushima et al., Tokyo, Japan. In Am J Pathol, Nov 2015
In gene ontology network analyses, many of these genes were associated with tissue remodeling and included genes not previously associated with PF, such as Mmp14, Thbs2, and Fgfr4.
Identification of Commonly Dysregulated Genes in Non-small-cell Lung Cancer by Integrated Analysis of Microarray Data and qRT-PCR Validation.
Review
New
Wang et al., Shijiazhuang, China. In Lung, Aug 2015
Our data suggested that some of the DEGs, including MMP12, COL11A1, THBS2, FAP, and CAV1, may participate in the pathology of NSCLC and could be applied as potential markers or therapeutic targets for NSCLC.
Delineation of candidate genes responsible for structural brain abnormalities in patients with terminal deletions of chromosome 6q27.
Review
Cheung et al., Houston, United States. In Eur J Hum Genet, 2015
The smallest region of overlap spans 1.7 Mb and contains DLL1, THBS2, PHF10, and C6orf70 (ERMARD) that are plausible candidates for the causation of structural brain abnormalities.
DNA hypermethylation and decreased mRNA expression of MAL, PRIMA1, PTGDR and SFRP1 in colorectal adenoma and cancer.
Molnár et al., Budapest, Hungary. In Bmc Cancer, 2014
Three of those (COL1A2, SFRP2, SOCS3) showed hypermethylation and THBS2 showed hypomethylation both in AD and in CRC samples compared to NAT, while BCL2, PRIMA1 and PTGDR showed hypermethylation only in the CRC group.
Matricellular protein thrombospondins: influence on ocular angiogenesis, wound healing and immuneregulation.
Review
Zieske et al., Boston, United States. In Curr Eye Res, 2014
Two members of the thrombospondin family, thrombospondin 1 (TSP-1) and thrombospondin 2 (TSP-2) are studied extensively to determine their structure and function.
Thrombospondin-2 and extracellular matrix assembly.
Review
Kyriakides et al., New Haven, United States. In Biochim Biophys Acta, 2014
Based on findings in TSP2-null mice and in vitro studies, we describe the participation of TSP2 in ECM assembly, cell-ECM interactions, and modulation of the levels of matrix metalloproteinases (MMPs).
Defects in tendon, ligament, and enthesis in response to genetic alterations in key proteoglycans and glycoproteins: a review.
Review
Veillette et al., Toronto, Canada. In Arthritis, 2012
The genes reviewed are for small leucine-rich proteoglycans (lumican, fibromodulin, biglycan, decorin, and asporin); dermatan sulfate epimerase (Dse) that alters structure of glycosaminoglycan and hence the function of small leucine-rich proteoglycans by converting glucuronic to iduronic acid; matricellular proteins (thrombospondin 2, secreted phosphoprotein 1 (Spp1), secreted protein acidic and rich in cysteine (Sparc), periostin, and tenascin X) including human tenascin C variants; and others, such as tenomodulin, leukocyte cell derived chemotaxin 1 (chondromodulin-I, ChM-I), CD44 antigen (Cd44), lubricin (Prg4), and aggrecan degrading gene, a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (Adamts5).
Two molecular weight species of thrombospondin-2 are present in bone and differentially modulated in fractured and nonfractured tibiae in a murine model of bone healing.
GeneRIF
Sharma et al., Ann Arbor, United States. In Calcif Tissue Int, 2012
the two TSP2 isforms are differentially modulated at injured and noninjured skeletal sites in an animal undergoing fracture healing.
Thrombospondin-2 prevents cardiac injury and dysfunction in viral myocarditis through the activation of regulatory T-cells.
GeneRIF
Heymans et al., Maastricht, Netherlands. In Cardiovasc Res, 2012
TSP-2 has a protective role against cardiac inflammation, injury, and dysfunction in acute viral myocarditis.
Increased thrombospondin-2 in human fibrosclerotic and stenotic aortic valves.
GeneRIF
Rysä et al., Oulu, Finland. In Atherosclerosis, 2012
Calcific aortic stenosis in associated with upregulation of TSP-2 expression, and inactivation of Akt and NF-kappaB.
Endothelial nitric oxide synthase controls the expression of the angiogenesis inhibitor thrombospondin 2.
GeneRIF
Kyriakides et al., New Haven, United States. In Proc Natl Acad Sci U S A, 2011
Endothelial nitric oxide synthase controls the expression of the angiogenesis inhibitor thrombospondin 2
An association study of thrombospondin 1 and 2 SNPs with coronary artery disease and myocardial infarction among South Indians.
GeneRIF
Cherian et al., Chennai, India. In Thromb Res, 2011
Data suggests that the presence of thrombospondin-1 (rs2228262) and thrombospondin-2 (rs8089) variants need not be considered a risk for coronary artery disease or myocardial infarction among South Indians.
Tetraspanins on the surface of Schistosoma mansoni are protective antigens against schistosomiasis.
Impact
Loukas et al., Brisbane, Australia. In Nat Med, 2006
Using a signal sequence trap, we cloned from Schistosoma mansoni two cDNAs, Sm-tsp-1 and Sm-tsp-2, encoding the tetraspanin (TSP) integral membrane proteins TSP-1 and TSP-2.
Impact of vascular endothelial growth factor-A expression, thrombospondin-2 expression, and microvessel density on the treatment effect of bevacizumab in metastatic colorectal cancer.
Impact
Koeppen et al., San Francisco, United States. In J Clin Oncol, 2006
The aim of these retrospective subset analyses was to evaluate VEGF, thrombospondin-2 (THBS-2), and microvessel density (MVD) as prognostic factors and/or predictors of benefit from bevacizumab.
Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivo.
Impact
GeneRIF
Byzova et al., Cleveland, United States. In Nat Med, 2005
Re-expression of TSP2 in mice transplanted with wild-type bone marrow corrected the angiogenic abnormalities in Akt1(-/-) mice.
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