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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Testis-specific serine kinase 1

Tsk1, TSSK1, testis-specific serine/threonine kinase, TSKI, TSSK
TSSK1 belongs to a family of serine/threonine kinases highly expressed in testis (Hao et al., 2004 [PubMed 15044604]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: Tsk2, CAN, clone 4, AGE, HAD
Papers on Tsk1
Recombinant production of enzymatically active male contraceptive drug target hTSSK2 - Localization of the TSKS domain phosphorylated by TSSK2.
Herr et al., Charlottesville, United States. In Protein Expr Purif, Feb 2016
UNASSIGNED: The testis-specific serine/threonine kinase 2 (TSSK2) has been proposed as a candidate male contraceptive target.
Patient kinesiophobia affects both recovery time and final outcome after total knee arthroplasty.
Marcacci et al., Bologna, Italy. In Knee Surg Sports Traumatol Arthrosc, Jan 2016
Kinesiophobia was assessed with the Tampa Scale for Kinesiophobia (TSK: Activity Avoidance-TSK1 and Harm-TSK2 subscales), and results were evaluated with range of motion, pain and function on 0-10 numeric rating scales, WOMAC and SF-12 (Physical and Mental subscales) scores.
Daily oscillations of skin temperature in military personnel using thermography.
Marins et al., Viçosa, Brazil. In J R Army Med Corps, Oct 2015
The purpose of this study was to determine oscillations in the skin temperature (Tsk-1-Tsk-25) at 25 body regions of interest (ROIs) over 1 day using infrared thermography.
S100A4 amplifies TGF-β-induced fibroblast activation in systemic sclerosis.
Distler et al., Praha, Czech Republic. In Ann Rheum Dis, Sep 2015
Deficiency of S100A4 also ameliorated fibrosis in the tight-skin-1 (Tsk-1) mouse model.
Activation of liver X receptors inhibits experimental fibrosis by interfering with interleukin-6 release from macrophages.
Distler et al., Erlangen, Germany. In Ann Rheum Dis, Jun 2015
METHODS: We studied the role of LXRs in bleomycin-induced skin fibrosis, in the model of sclerodermatous graft-versus-host disease (sclGvHD) and in tight skin-1 (Tsk-1) mice, reflecting different subtypes of fibrotic disease.
Testis specific serine/threonine protein kinase 4 (TSSK4) leads to cell apoptosis relying on its kinase activity.
Yu et al., Shanghai, China. In J Huazhong Univ Sci Technolog Med Sci, Apr 2015
Testis specific serine/threonine protein kinase 4 (TSSK4) belongs to the TSSK family, and its members play an important role in spermatogenesis and/or spermiogenesis.
Tssk4 is essential for maintaining the structural integrity of sperm flagellum.
Yu et al., Wuhan, China. In Mol Hum Reprod, Feb 2015
Tssk4 belongs to the Testis Specific Serine/threonine protein Kinase (TSSK) family, members of which play an important role in spermatogenesis and/or spermiogenesis.
Cardiomyopathy in murine models of systemic sclerosis.
Distler et al., Stockholm, Sweden. In Arthritis Rheumatol, Feb 2015
METHODS: The histopathologic features of myocardial tissue specimens obtained at autopsy from 5 subjects with SSc and 5 control subjects matched for sex, age, and cardiovascular risk factors were evaluated and compared with those of myocardial tissue specimens obtained from 3 common mouse models of SSc with systemic manifestations: Fra-2-transgenic mice, mice with sclerodermatous chronic graft-versus-host disease (GVHD), and TSK-1 mice.
Cloning, sequence characterization, and expression patterns of members of the porcine TSSK family.
Xiao et al., Kunming, China. In Genet Mol Res, 2014
Here, five members of the TSSK family from a Banna mini-pig inbred line (BMI) were cloned, sequenced, and characterized.
PPP1CC2 can form a kinase/phosphatase complex with the testis-specific proteins TSSK1 and TSKS in the mouse testis.
Varmuza et al., Toronto, Canada. In Reproduction, 2014
Amongst the identified candidate interactors was the testis-specific protein kinase TSSK1, which is also essential for male fertility.
Levels of target activation predict antifibrotic responses to tyrosine kinase inhibitors.
Distler et al., Zürich, Switzerland. In Ann Rheum Dis, 2013
METHODS: Skin sections of bleomycin, TSK1, Fra-2 transgenic mice, SSc patients and controls were analysed by histology and immunohistochemistry. Subgroups of mice were treated with the TKIs nilotinib or imatinib.
Targeting IL-6 by both passive or active immunization strategies prevents bleomycin-induced skin fibrosis.
Allanore et al., In Arthritis Res Ther, 2013
Then, we assessed the efficacy of MR16-1 in tight skin-1 (Tsk-1) mice, an inflammation-independent model of skin fibrosis.
Functional transformation of the chromatoid body in mouse spermatids requires testis-specific serine/threonine kinases.
Grootegoed et al., Rotterdam, Netherlands. In J Cell Sci, 2010
Results reveal TSSK1- and TSSK2-dependent functions of a transformed chromatoid body in post-meiotic cytodifferentiation of spermatids.
TSKS concentrates in spermatid centrioles during flagellogenesis.
Herr et al., Charlottesville, United States. In Dev Biol, 2008
Deletion of Tssk2 kinase/substrate pair is predicted to play an indispensable role during spermiogenesis
Targeted deletion of Tssk1 and 2 causes male infertility due to haploinsufficiency.
Herr et al., Charlottesville, United States. In Dev Biol, 2008
Results confirm both TSSK 2 and TSKS persist in sperm, define a critical role of TSKS' N-terminus in enzyme interaction, identify Ser 281 as a TSKS phosphorylation site and indicate an indispensable role for TSSK 1 and 2 in spermiogenesis.
Validation of a testis specific serine/threonine kinase [TSSK] family and the substrate of TSSK1 & 2, TSKS, as contraceptive targets.
Herr et al., Charlottesville, United States. In Soc Reprod Fertil Suppl, 2006
A family of testis specific serine/threonine kinases, TSSK1-4 and SSTK, in addition to the substrate of TSSK1 & 2, TSKS, have been studied during the past several years in our laboratory.
Fibrosis in connective tissue disease: the role of the myofibroblast and fibroblast-epithelial cell interactions.
Lafyatis et al., Köln, Germany. In Arthritis Res Ther, 2006
The tight skin mouse (Tsk-1) model of cutaneous fibrosis suggests that numerous other genes may also be important.
Transgenic analysis of scleroderma: understanding key pathogenic events in vivo.
Abraham et al., London, United Kingdom. In Autoimmun Rev, 2004
The best characterized scleroderma animal model is the type 1 tight skin mouse (Tsk1).
Immunohistochemical analysis of the expression of two serine-threonine kinases in the maturing mouse testis.
Buck et al., Philadelphia, United States. In Mech Dev, 1998
The expression patterns of Tsk1 is documented throughout spermiogenesis showing an initial association of Tsk1 with cells in meiotic metaphase.
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