Genetics of Graves' Disease: Special Focus on the Role of TSHR Gene.
Barcelona, Spain. In Horm Metab Res, Sep 2015
Also, as in other autoimmune diseases, family linkage, candidate gene association, and GWAS studies have identified an expanding number of predisposing genes (CTLA4, CD40, PTPN22...) and 2 of them, TG and TSHR, are thyroid specific.
Mechanisms of Action of TSHR Autoantibodies.
Cardiff, United Kingdom. In Horm Metab Res, Sep 2015
The availability of human monoclonal antibodies (MAbs) to the TSHR has enabled major advances in our understanding of how TSHR autoantibodies interact with the receptor.
Human fibrocytes coexpress thyroglobulin and thyrotropin receptor.
Ann Arbor, United States. In Proc Natl Acad Sci U S A, 2012
Findings suggest that thyroglobulin (Tg) and thyroid-stimulating hormone receptor (TSHR) detected in orbital connective tissues in thyroid-associated ophthalmopathy (TAO) result from local fibrocyte biosynthetic activity.