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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Thyroid stimulating hormone receptor

TSHR, thyrotropin receptor
The protein encoded by this gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008] (from NCBI)
Top mentioned proteins: HAD, CAN, thyroglobulin, thrombopoietin, V1a
Papers on TSHR
Synthetic gene network restoring endogenous pituitary-thyroid feedback control in experimental Graves' disease.
Fussenegger et al., Basel, Switzerland. In Proc Natl Acad Sci U S A, Feb 2016
UNASSIGNED: Graves' disease is an autoimmune disorder that causes hyperthyroidism because of autoantibodies that bind to the thyroid-stimulating hormone receptor (TSHR) on the thyroid gland, triggering thyroid hormone release.
The influence of dihydrotestosterone on the development of Graves' disease in female BALB/c mice.
Shi et al., Xi'an, China. In Thyroid, Feb 2016
METHODS: Female BALB/c mice were immunized three times with the thyroid stimulating hormone receptor (TSHR) A-subunit.
Pathogenesis of thyroid eye disease: review and update on molecular mechanisms.
Selva et al., Melbourne, Australia. In Br J Ophthalmol, Jan 2016
Orbital fibroblasts express both thyrotropin receptor (TSHR) and insulin-like growth factor-1 receptor (IGF-1R) at higher levels than normal fibroblasts.
Current perspectives on the role of orbital fibroblasts in the pathogenesis of Graves' ophthalmopathy.
van Steensel et al., Rotterdam, Netherlands. In Exp Eye Res, Jan 2016
Orbital fibroblasts, especially from GO patients, express the thyrotropin receptor (TSH-receptor; TSHR), and activation of the orbital fibroblast population by stimulatory autoantibodies directed against the TSHR may provide an important link between GD and GO.
Novel c.554+5C>T Mutation in the DUOXA2 gene Combinated with p.R885Q Mutation in the DUOX2 Gene Causes Congenital Hypothyroidism.
Shao et al., In J Clin Res Pediatr Endocrinol, Jan 2016
The DUOXA2, DUOX2, thyroid peroxidase (TPO), and thyrotropin receptor (TSHR) genes were considered for genetic defects screening.
Combined analysis of circulating epithelial cells and serum thyroglobulin for distinguishing disease status of the patients with papillary thyroid carcinoma.
Lin et al., Taiwan. In Oncotarget, Jan 2016
The number of CECs expressing epithelial cell adhesion molecule (EpCAM) or thyroid-stimulating hormone receptor (TSHR) was determined by immunofluorescence microscopy analyses.
Current Insights into the Pathogenesis of Graves' Ophthalmopathy.
Bahn, Rochester, United States. In Horm Metab Res, Sep 2015
The finding that the thyrotropin receptor (TSHR) is expressed in orbital fibroblasts, the target cells in GO, supported the notion of a common autoantigen.
Genetics of Graves' Disease: Special Focus on the Role of TSHR Gene.
Colobran et al., Barcelona, Spain. In Horm Metab Res, Sep 2015
Also, as in other autoimmune diseases, family linkage, candidate gene association, and GWAS studies have identified an expanding number of predisposing genes (CTLA4, CD40, PTPN22...) and 2 of them, TG and TSHR, are thyroid specific.
Mechanisms of Action of TSHR Autoantibodies.
Rees Smith et al., Cardiff, United Kingdom. In Horm Metab Res, Sep 2015
The availability of human monoclonal antibodies (MAbs) to the TSHR has enabled major advances in our understanding of how TSHR autoantibodies interact with the receptor.
Mining Chemical Activity Status from High-Throughput Screening Assays.
Bajic et al., Saudi Arabia. In Plos One, 2014
As an example of potential use, we applied DRAMOTE to develop robust models for predicting FDA approved drugs that have high probability to interact with the thyroid stimulating hormone receptor (TSHR) in humans.
Breaking tolerance to thyroid antigens: changing concepts in thyroid autoimmunity.
Rapoport et al., Los Angeles, United States. In Endocr Rev, 2014
The TSH receptor (TSHR), thyroid peroxidase (TPO), and thyroglobulin (Tg) have unusual properties ("immunogenicity") that contribute to breaking tolerance, including size, abundance, membrane association, glycosylation, and polymorphisms.
Novel insights on thyroid-stimulating hormone receptor signal transduction.
Biebermann et al., Berlin, Germany. In Endocr Rev, 2013
The TSH receptor (TSHR) is a member of the glycoprotein hormone receptors, a subfamily of family A G protein-coupled receptors.
Expression of functional TSH receptor in white adipose tissues of hyt/hyt mice induces lipolysis in vivo.
Kobayashi et al., Japan. In Am J Physiol Endocrinol Metab, 2012
Messenger RNA levels of hormone-sensitive lipase in epididymal fat containing the transferred TSHR gene were twofold higher than those in tissue from the control side
R450H TSH receptor mutation in congenital hypothyroidism in Taiwanese children.
Chao et al., Kao-hsiung, Taiwan. In Clin Chim Acta, 2012
R450H TSH receptor mutation was relatively important in the Taiwanese children with congenital hypothyroidism
PDGF enhances orbital fibroblast responses to TSHR stimulating autoantibodies in Graves' ophthalmopathy patients.
Dik et al., Rotterdam, Netherlands. In J Clin Endocrinol Metab, 2012
PDGF-B containing PDGF isoforms amplify the immunopathological effects of TSHR-stimulating autoantibodies in Graves ophthalmopathy patients by stimulating TSHR expression on orbital fibroblasts.
Human fibrocytes coexpress thyroglobulin and thyrotropin receptor.
Smith et al., Ann Arbor, United States. In Proc Natl Acad Sci U S A, 2012
Findings suggest that thyroglobulin (Tg) and thyroid-stimulating hormone receptor (TSHR) detected in orbital connective tissues in thyroid-associated ophthalmopathy (TAO) result from local fibrocyte biosynthetic activity.
TSHR is the main causative locus in autosomal recessively inherited thyroid dysgenesis.
Maher et al., Birmingham, United Kingdom. In J Pediatr Endocrinol Metab, 2011
We conclude that TSHR mutations are the main detectable cause of autosomal recessively inherited thyroid dysgenesis.
A genome-wide association study identifies two new risk loci for Graves' disease.
China Consortium for Genetics of Autoimmune Thyroid Disease et al., Shanghai, China. In Nat Genet, 2011
Graves' disease is a common autoimmune disorder characterized by thyroid stimulating hormone receptor autoantibodies (TRAb) and hyperthyroidism.
Whole-genome resequencing reveals loci under selection during chicken domestication.
Andersson et al., Uppsala, Sweden. In Nature, 2010
One of the most striking selective sweeps found in all domestic chickens occurred at the locus for thyroid stimulating hormone receptor (TSHR), which has a pivotal role in metabolic regulation and photoperiod control of reproduction in vertebrates.
Thyrotropin and homologous glycoprotein hormone receptors: structural and functional aspects of extracellular signaling mechanisms.
Krause et al., Berlin, Germany. In Endocr Rev, 2009
The TSH receptor (TSHR) together with the homologous lutropin/choriogonadotropin receptor and the follitropin receptor are glycoprotein hormone receptors (GPHRs).
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