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Thyroid stimulating hormone receptor

TSHR, thyrotropin receptor
The protein encoded by this gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008] (from NCBI)
Papers on TSHR
Expression of functional TSH receptor in white adipose tissues of hyt/hyt mice induces lipolysis in vivo.
Kobayashi et al., Japan. In Am J Physiol Endocrinol Metab, 2012
Messenger RNA levels of hormone-sensitive lipase in epididymal fat containing the transferred TSHR gene were twofold higher than those in tissue from the control side
R450H TSH receptor mutation in congenital hypothyroidism in Taiwanese children.
Chao et al., Kao-hsiung, Taiwan. In Clin Chim Acta, 2012
R450H TSH receptor mutation was relatively important in the Taiwanese children with congenital hypothyroidism
PDGF enhances orbital fibroblast responses to TSHR stimulating autoantibodies in Graves' ophthalmopathy patients.
Dik et al., Rotterdam, Netherlands. In J Clin Endocrinol Metab, 2012
PDGF-B containing PDGF isoforms amplify the immunopathological effects of TSHR-stimulating autoantibodies in Graves ophthalmopathy patients by stimulating TSHR expression on orbital fibroblasts.
Human fibrocytes coexpress thyroglobulin and thyrotropin receptor.
Smith et al., Ann Arbor, United States. In Proc Natl Acad Sci U S A, 2012
Findings suggest that thyroglobulin (Tg) and thyroid-stimulating hormone receptor (TSHR) detected in orbital connective tissues in thyroid-associated ophthalmopathy (TAO) result from local fibrocyte biosynthetic activity.
TSHR is the main causative locus in autosomal recessively inherited thyroid dysgenesis.
Maher et al., Birmingham, United Kingdom. In J Pediatr Endocrinol Metab, 2011
We conclude that TSHR mutations are the main detectable cause of autosomal recessively inherited thyroid dysgenesis.
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