TSH receptor - autoantibody interactions.
Cardiff, United Kingdom. In Horm Metab Res, 2009
Comparison of M22 and TSH interactions with the TSHR at the atomic level reveal that M22 heavy and light chains mimic TSH alpha and beta chains, respectively, in the way they bind to the receptor, but the evolutionary forces which have caused this close molecular mimicry are as yet completely unknown.
Involvement of thyrotropin in photoperiodic signal transduction in mice.
Nagoya, Japan. In Proc Natl Acad Sci U S A, 2008
Although most mouse strains are considered to be nonseasonal, a robust photoperiodic response comprising induced expression of TSHB (TSH beta subunit), CGA (TSH alpha subunit), and DIO2, and reduced expression of DIO3, was observed in melatonin-proficient CBA/N mice.
Cranial irradiation and central hypothyroidism.
Cincinnati, United States. In Trends Endocrinol Metab, 2001
TRH deficiency leads to abnormal glycosylation of TSH alpha and beta subunits and loss of the normal circadian pattern of TSH secretion (low in the afternoon, a surge in the evening, higher at night).