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Tumor susceptibility gene 101

TSG101, CC2, DPP6, tumor susceptibility gene 101
The protein encoded by this gene belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. The gene product contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated in tumorigenesis. The protein may play a role in cell growth and differentiation and act as a negative growth regulator. In vitro steady-state expression of this tumor susceptibility gene appears to be important for maintenance of genomic stability and cell cycle regulation. Mutations and alternative splicing in this gene occur in high frequency in breast cancer and suggest that defects occur during breast cancer tumorigenesis and/or progression. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, V1a, Ubiquitin, HAD, SET
Papers using TSG101 antibodies
SNX1 defines an early endosomal recycling exit for sortilin and mannose 6-phosphate receptors
Pfeffer Suzanne, In PLoS Biology, 2007
... (BD Biosciences); α-tubulin (Sigma-Aldrich); ubiquitinated proteins (FK2) (Affinity Research Products); clathrin (X22) (ABR-Affinity BioReagents); and TSG101 (GeneTex).
[DREAM/Calsenilin/KChIP3: a new multifunctional protein in nervous system]
Rudy Bernardo et al., In Frontiers in Molecular Neuroscience, 2004
... (Sf9) cells (Invitrogen) were transfected with pAcGP67A carrying the DPP6 cDNA and linearized AcNPV DNA (Sapphire Baculovirus DNA; Orbigen).
A TSG101/MDM2 regulatory loop modulates MDM2 degradation and MDM2/p53 feedback control.
Farzan Michael, In PLoS Pathogens, 2000
... Mouse mAbs recognizing Hrs and Tsg101 were purchased from Alexis Biochemicals (Lausen, Switzerland) and GeneTex (Irvine, CA), while rabbit ...
Papers on TSG101
Multiple calibrator measurements improve accuracy and stability estimates of automated assays.
Klee et al., Rochester, United States. In Scand J Clin Lab Invest, Feb 2016
Methods Three calibration procedures (CC1, CC2 and CC3) combined 12, 34 and 56 calibrator measurements over 1, 2, and 3 days.
Cell culture density affects the proliferation activity of human adipose tissue stem cells.
Yoo et al., Seoul, South Korea. In Cell Biochem Funct, Feb 2016
Passage #4 (P4) and #12 (P12) AT-MSCs from two donors were plated at a density of 200 (culture condition 1, CC1) or 5000 (culture condition 2, CC2) cells cm(-2) .
Coupled Cluster Evaluation of the Stability of Atmospheric Acid-Base Clusters with up to 10 Molecules.
Vehkamaki et al., In J Phys Chem A, Feb 2016
Using the Atmospheric Cluster Dynamics Code (ACDC) we compare the sulfuric acid dimer formation based on the new DLPNO binding energies with previously published RI-CC2/aug-cc-pV(T+d)Z results.
Theoretical analysis of the S2←S0 vibronic spectrum of the 2-pyridone dimer.
Köppel et al., Heidelberg, Germany. In J Chem Phys, Feb 2016
This is based on potential energy surfaces obtained at the RI-CC2/aug-cc-pVTZ level.
Genetic variants in EBV reactivation-related genes and the risk and survival of breast cancer.
Ren et al., Guangzhou, China. In Tumour Biol, Feb 2016
UNASSIGNED: Tumor susceptibility gene 101 (TSG101) and activating transcription factor 2 (ATF2) have been suggested to involve in the reactivation of EBV which has implications in the development and progression of breast cancer.
Unravelling the immunological roles of dipeptidyl peptidase 4 (DPP4) activity and/or structure homolog (DASH) proteins.
von Hörsten et al., Stuttgart, Germany. In Clin Exp Immunol, Jan 2016
Apart from DPP4, DASH proteins include fibroblast activation protein alpha (FAP), dipeptidyl peptidase 8 (DPP8), dipeptidyl peptidase 9 (DPP9), dipeptidyl peptidase 4-like protein 1 (DPL1, DPP6, DPPX L, DPPX S), dipeptidyl peptidase 4-like protein 2 (DPL2, DPP10) from the DPP4-gene family S9b and structurally unrelated enzyme dipeptiyl peptidase 2 (DPP2), displaying DPP4-like activity.
Complete versus incomplete cytoreduction in peritoneal carcinosis from gastric cancer, with consideration to PCI cut-off. Systematic review and meta-analysis.
Ansaloni et al., Bergamo, Italy. In Eur J Surg Oncol, Jul 2015
RESULTS: Nine trials have been included (748 patients: 417 with CC0-CC1 and 324 with CC2-CC3 cytoreduction).
Role of vascular inflammation in coronary artery disease: potential of anti-inflammatory drugs in the prevention of atherothrombosis. Inflammation and anti-inflammatory drugs in coronary artery disease.
Gottschall et al., Porto Alegre, Brazil. In Am J Cardiovasc Drugs, Feb 2015
The blockage of other potential targets, such as the IL-6 receptor, CC2 chemokine receptor and CD20, could bring benefits in CAD.
Spectroscopy of nitrophenolates in vacuo: effect of spacer, configuration, and microsolvation on the charge-transfer excitation energy.
Rubio et al., Århus, Denmark. In Acc Chem Res, 2014
Our work shows that CC2 coupled-cluster calculations of vertical excitation energies are within 0.2 eV of experimental band maxima, and importantly, that the theoretical method is excellent in predicting the relative order of excitation energies of a series of nitrophenolates.
Polarized release of T-cell-receptor-enriched microvesicles at the immunological synapse.
Dustin et al., New York City, United States. In Nature, 2014
Tumour susceptibility gene 101 (TSG101) sorts TCRs for inclusion in microvesicles, whereas vacuolar protein sorting 4 (VPS4) mediates scission of microvesicles from the T-cell plasma membrane.
Role of TSG101 in cancer.
Cheng et al., Galveston, United States. In Front Biosci, 2012
The tumor susceptibility gene 101 (TSG101) encodes a multidomain protein that contains a UEV (ubiquitin e2 variant) domain at is N-terminus and a putative DNA-binding motif at its C-terminus.
[Multidisciplinary management of rectal cancer].
Valentini et al., Brescia, Italy. In Cancer Radiother, 2012
The aim of this article is to present highlights of multidisciplinary rectal cancer management and to compare the conclusions of the international conference on 'Multidisciplinary Rectal Cancer Treatment: looking for an European Consensus' (EURECA-CC2) with the new National Comprehensive Cancer Network (NCCN) guidelines.
Re-splicing of mature mRNA in cancer cells promotes activation of distant weak alternative splice sites.
Mayeda et al., Japan. In Nucleic Acids Res, 2012
The results provide evidence for a two-step splicing pathway of the TSG101 mRNA in which the initial constitutive splicing removes all 14 authentic splice sites, thereby bringing the weak alternative splice sites into close proximity.
[Expression and significance of tumor susceptibility gene 101 in hepatocellular carcinoma tissues].
Liu et al., Xinpu, China. In Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2012
The expression of TSG101 in HCC is higher than that in corresponding non-cancer tissues and the expression level is closely correlated with TNM stage and metastasis of HCC.
Genome wide analysis of acute myeloid leukemia reveal leukemia specific methylome and subtype specific hypomethylation of repeats.
Young et al., London, United Kingdom. In Plos One, 2011
Results showed that DPP6, SPHKAP and ID4 were down regulated in acute myeloid leukemia (AML) patients.
A knockout of the Tsg101 gene leads to decreased expression of ErbB receptor tyrosine kinases and induction of autophagy prior to cell death.
Wagner et al., Omaha, United States. In Plos One, 2011
Tsg101 has a role in expression of EGFR and ErbB2 and preventing induction of autophagy prior to cell death
Incorporation of DPP6a and DPP6K variants in ternary Kv4 channel complex reconstitutes properties of A-type K current in rat cerebellar granule cells.
Pfaffinger et al., Houston, United States. In Plos One, 2011
The unique N-terminus of DPP6K modulates the effects of KChIP proteins, slowing recovery and producing a negative shift in the steady-state inactivation curve.
Essential role of ubiquitin and TSG101 protein in formation and function of the central supramolecular activation cluster.
Dustin et al., New York City, United States. In Immunity, 2010
show that ubiquitin recognition by TSG101 is required for cSMAC formation, T cell receptor (TCR) microcluster signal termination, TCR downregulation.
Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation.
Iwai et al., Suita, Japan. In Nat Cell Biol, 2009
Here, we demonstrate that LUBAC activates the canonical NF-kappaB pathway by binding to NEMO (NF-kappaB essential modulator, also called IKKgamma) and conjugates linear polyubiquitin chains onto specific Lys residues in the CC2-LZ domain of NEMO in a Ubc13-independent manner.
Midbody targeting of the ESCRT machinery by a noncanonical coiled coil in CEP55.
Hurley et al., Bethesda, United States. In Science, 2008
Biochemical experiments show that peptides from ALIX and the ESCRT-I subunit TSG101 compete for binding to the ESCRT and ALIX-binding region (EABR) of CEP55.
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