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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Twisted gastrulation homolog 1

TSG
Top mentioned proteins: TSG-6, CAN, HAD, p53, V1a
Papers on TSG
Mesenchymal stem/stromal cells precondition lung monocytes/macrophages to produce tolerance against allo- and autoimmunity in the eye.
New
Oh et al., Seoul, South Korea. In Proc Natl Acad Sci U S A, Feb 2016
infusion of MSCs preconditioned lung monocytes/macrophages toward an immune regulatory phenotype in a TNF-α-stimulated gene/protein (TSG)-6-dependent manner.
Niche Regulation of Limbal Epithelial Stem Cells: Relationship between Inflammation and Regeneration.
Review
New
Chen et al., Miami, United States. In Ocul Surf, Feb 2016
HC-HA complex is covalently formed by hyaluronan (HA) and heavy chain 1 (HC1) of inter-α-trypsin inhibitor by the catalytic action of tumor necrosis factor-stimulated gene-6 (TSG-6) and are tightly associated with pentraxin 3 (PTX3) to form HC-HA/PTX3.
Targeting calcium signaling induces epigenetic reactivation of tumor suppressor genes in cancer.
New
Issa et al., Temple, United States. In Cancer Res, Jan 2016
Here, we report on the unexpected finding that targeting calcium signaling can reverse epigenetic silencing of tumor suppressor genes (TSG).
Re-expression of selected epigenetically silenced candidate tumor suppressor genes in cervical cancer by TET2-directed demethylation.
New
Rots et al., Groningen, Netherlands. In Mol Ther, Jan 2016
To redirect TET2 to hypermethylated TSGs, we engineered zinc finger proteins (ZFPs), which were first fused to the transcriptional activator VP64 to validate effective gene re-expression and confirm TSG function.
Oncogene-tumor suppressor gene feedback interactions and their control.
New
Chan et al., Bethesda, United States. In Math Biosci Eng, Jan 2016
We propose the hypothesis that for a particular type of cancer there exists a key pair of oncogene (OCG) and tumor suppressor gene (TSG) that is normally involved in strong stabilizing negative feedback loops (nFBLs) of molecular interactions, and it is these interactions that are sufficiently perturbed during cancer development.
The role of chordin fragments generated by partial tolloid cleavage in regulating BMP activity.
Review
New
Baldock et al., Köln, Germany. In Biochem Soc Trans, Nov 2015
The chordin-BMP inhibitory complex is strengthened by the secreted glycoprotein twisted gastrulation (Tsg); however, inhibition is relieved by cleavage of chordin at two specific sites by tolloid family metalloproteases.
Influence of colorectal cancer tumor suppressor gene CHD5 methylation on its clinical and pathological characteristics.
New
Yuan et al., Zhengzhou, China. In J Biol Regul Homeost Agents, Oct 2015
Recently, abnormal tumor suppressor gene (TSG) methylation has become a hotspot in the research on colorectal cancer (CRC).
The Rise and Fall of Hyaluronan in Respiratory Diseases.
Review
Aronica et al., Cleveland, United States. In Int J Cell Biol, 2014
During inflammation in the airways, HA is often covalently modified with heavy chains from inter-alpha-inhibitor via the enzyme tumor-necrosis-factor-stimulated-gene-6 (TSG-6) and this modification promotes the interaction of leukocytes with HA matrices at sites of inflammation.
The Bone Morphogenetic Proteins and Their Antagonists.
Review
Rider et al., London, United Kingdom. In Vitam Horm, 2014
One mechanism for enabling tight spatiotemporal control of their activities is through a number of antagonist proteins, including Noggin, Follistatin, Chordin, Twisted gastrulation (TSG), and the seven members of the Cerberus and Dan family.
ROS-mediated DNA methylation pattern alterations in carcinogenesis.
Review
Ni et al., Shanghai, China. In Curr Drug Targets, 2014
ROS-induced oxidative stress is associated with both aberrant hypermethylation of tumor suppressor gene (TSG) promoter regions and global hypomethylation.
Cumulative haploinsufficiency and triplosensitivity drive aneuploidy patterns and shape the cancer genome.
Impact
Elledge et al., Boston, United States. In Cell, 2013
Here, we develop Tumor Suppressor and Oncogene (TUSON) Explorer, a computational method that analyzes the patterns of mutational signatures in tumors and predicts the likelihood that any individual gene functions as a tumor suppressor (TSG) or oncogene (OG).
Compartmentalization of bone morphogenetic proteins and their antagonists in lymphoid progenitors and supporting microenvironments and functional implications.
GeneRIF
Graf et al., Greece. In Immunology, 2011
Data show that Bmp4, Bmp7, Gremlin and Twisted gastrulation (Twsg1) are all expressed in the thymus and expression was clearly different for each gene investigated.
The molecular and cellular basis of variable craniofacial phenotypes and their genetic rescue in Twisted gastrulation mutant mice.
GeneRIF
Petryk et al., Minneapolis, United States. In Dev Biol, 2011
These results demonstrate that phenotypic variability in Twsg1-/- mice is associated with differential expression of certain developmentally regulated genes, and that craniofacial defects can be partially rescued by reduced p53 levels.
Involvement of twisted gastrulation in T cell-independent plasma cell production.
GeneRIF
Graf et al., Greece. In J Immunol, 2011
suggesting that Twsg1 expression in B cells serves to interpret BMP signals on a per-cell basis
Minimal evidence for a direct involvement of twisted gastrulation homolog 1 (TWSG1) gene in human holoprosencephaly.
GeneRIF
Muenke et al., Bethesda, United States. In Mol Genet Metab, 2011
mutations in the twisted gastrulation homolog 1 gene are neither a common direct cause nor a frequent modifying factor for human holoprosencephaly pathologies
Bone morphogenetic protein 2 signaling in osteoclasts is negatively regulated by the BMP antagonist, twisted gastrulation.
GeneRIF
Mansky et al., Minneapolis, United States. In J Cell Biochem, 2011
TWSG1 overexpression inhibits RANKL-induced osteoclast differentiation
Wilms' tumours: about tumour suppressor genes, an oncogene and a chameleon gene.
Review
Impact
Huff, Houston, United States. In Nat Rev Cancer, 2011
Genes identified as being mutated in Wilms' tumour include TP53, a classic tumour suppressor gene (TSG); CTNNB1 (encoding β-catenin), a classic oncogene; WTX, which accumulating data indicate is a TSG; and WT1, which is inactivated in some Wilms' tumours, similar to a TSG.
Subtle variations in Pten dose determine cancer susceptibility.
Impact
Pandolfi et al., Boston, United States. In Nat Genet, 2010
Cancer susceptibility has been attributed to at least one heterozygous genetic alteration in a tumor suppressor gene (TSG).
Sleuthing the source of regeneration by MSCs.
Impact
Pittenger, Baltimore, United States. In Cell Stem Cell, 2009
In this issue of Cell Stem Cell, Lee et al. (2009) investigate the production of the soluble inflammation inhibitor TSG-6 by MSCs.
Intravenous hMSCs improve myocardial infarction in mice because cells embolized in lung are activated to secrete the anti-inflammatory protein TSG-6.
Impact
Prockop et al., New Orleans, United States. In Cell Stem Cell, 2009
The hMSCs in lung upregulated expression of multiple genes, with a large increase in the anti-inflammatory protein TSG-6.
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