Hyaluronan Rafts on Airway Epithelial Cells.
Cleveland, United States. In J Biol Chem, Feb 2016
The transesterification transfer of HCs from chondroitin sulfate to HA is mediated by tumor necrosis factor-induced gene 6 (TSG-6), which is up-regulated in inflammatory reactions.
JNK2 controls aggrecan degradation in murine articular cartilage and the development of experimental osteoarthritis.
Oxford, United Kingdom. In Arthritis Rheumatol, Jan 2016
These included Has1, ADAMTS4, Tnf, IL6, IL18, Inhba, Cd68, Ngf, Ccr2, Wnt16, Tnfaip6 and Il1r, but not ADAMTS-5.
An RNA interference screen identifies new avenues for nephroprotection.
Buffalo, United States. In Cell Death Differ, Dec 2015
We used an RNA interference screen to identify genes (BCL2L14, BLOC1S2, C2ORF42, CPT1A, FBP1, GCNT3, RHOB, SCIN, TACR1, and TNFAIP6) whose suppression improves survival of kidney epithelial cells in in vitro models of oxygen and glucose deprivation.
The Rise and Fall of Hyaluronan in Respiratory Diseases.
Cleveland, United States. In Int J Cell Biol, 2014
During inflammation in the airways, HA is often covalently modified with heavy chains from inter-alpha-inhibitor via the enzyme tumor-necrosis-factor-stimulated-gene-6 (TSG-6) and this modification promotes the interaction of leukocytes with HA matrices at sites of inflammation.