Generation of serotonin neurons from human pluripotent stem cells.
Madison, United States. In Nat Biotechnol, Jan 2016
The serotonin neurons express a series of molecules essential for serotonergic development, including tryptophan hydroxylase 2, exhibit typical electrophysiological properties and release serotonin in an activity-dependent manner.
Serotonergic gene variation in substance use pharmacotherapy: a systematic review.
Houston, United States. In Pharmacogenomics, 2014
Current evidence suggests that genetic variability of the serotonergic biosynthesis enzyme tryptophan hydroxylase 2 (TPH2) and the serotonin transporter (SLC6A4) genes mediates the efficacy of several addiction treatments, such as ondansetron and disulfiram, and the antidepressants bupropion, nortriptyline and sertraline.
[Difference in target antigens between central tolerance and peripheral tolerance deficiencies].
Japan. In Nihon Rinsho Meneki Gakkai Kaishi, 2014
In addition to the differences in target organs, we have found differences in the target antigens in the same organ, small intestine, between both disorders; anti-autoimmune enteropathy-related 75 kDa antigen (AIE-75) antibodies are specific to IPEX syndrome, whereas anti-tryptophan hydroxylase-1 (TPH-1) antibodies are specific to APECED.