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Tryptophan hydroxylase 1

tryptophan hydroxylase, TPH1
This gene encodes a member of the aromatic amino acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene have been associated with an elevated risk for a variety of diseases and disorders, including schizophrenia, somatic anxiety, anger-related traits, bipolar disorder, suicidal behavior, addictions, and others.[provided by RefSeq, Apr 2009] (from NCBI)
Top mentioned proteins: TPH2, HAD, ACID, CAN, V1a
Papers on tryptophan hydroxylase
Gastric ghrelin, GOAT, leptin, and leptinR expression as well as peripheral serotonin are dysregulated in humans with obesity.
New
Bischoff et al., Stuttgart, Germany. In Neurogastroenterol Motil, Feb 2016
Ghrelin, ghrelin O-acyl transferase (GOAT), leptin, leptin receptor, and tryptophan hydroxylase 1 (TPH1) mRNA expression were measured by qRT-PCR.
Lipidomic profiling of tryptophan hydroxylase 2 knockout mice reveals novel lipid biomarkers associated with serotonin deficiency.
New
Liu et al., Beijing, China. In Anal Bioanal Chem, Feb 2016
This study therefore aimed to identify novel lipid biomarkers associated with serotonin deficiency by lipidomic profiling of tryptophan hydroxylase 2 knockout (Tph2-/-) mice.
Genetic variation in the tryptophan hydroxylase 2 gene moderates depressive symptom trajectories and remission over 8 weeks of escitalopram treatment.
New
Si et al., Beijing, China. In Int Clin Psychopharmacol, Feb 2016
UNASSIGNED: The serotonin system plays an important role in the pathogenesis of major depressive disorder (MDD) and genetic variations in serotonin-related genes affect the efficacy of antidepressants.
Imaging genetics studies on monoaminergic genes in major depressive disorder.
Review
New
Ham et al., Seoul, South Korea. In Prog Neuropsychopharmacol Biol Psychiatry, Feb 2016
This paper attempts to provide a comprehensive review of available imaging genetics studies, including reports on genetic variants that have most frequently been linked to MDD, such as the monoaminergic genes (serotonin transporter gene, monoamine oxidase A gene, tryptophan hydroxylase-2 gene, serotonin receptor 1A gene and catechol-O-methyl transferase gene), with regard to key structures involved in emotion processing, such as the hippocampus, amygdala, anterior cingulate cortex and orbitofrontal cortex.
Generation of serotonin neurons from human pluripotent stem cells.
New
Impact
Zhang et al., Madison, United States. In Nat Biotechnol, Jan 2016
The serotonin neurons express a series of molecules essential for serotonergic development, including tryptophan hydroxylase 2, exhibit typical electrophysiological properties and release serotonin in an activity-dependent manner.
A review of genetic alterations in the serotonin pathway and their correlation with psychotic diseases and response to atypical antipsychotics.
Review
New
Mavreas et al., Ioánnina, Greece. In Schizophr Res, Jan 2016
All the serotonin elements - serotonin receptors, serotonin transporter, tryptophan hydroxylase and monoamine oxidase proteins - can show alterations in terms of mRNA or protein levels and protein sequence, in schizophrenia and bipolar disorder.
The combination of ethanol with mephedrone increases the signs of neurotoxicity and impairs neurogenesis and learning in adolescent CD-1 mice.
New
Escubedo et al., Barcelona, Spain. In Toxicol Appl Pharmacol, Jan 2016
The combination with ethanol impaired mephedrone-induced decreases in dopamine transporter and tyrosine hydroxylase in the frontal cortex; and in serotonin transporter and tryptophan hydroxylase in the hippocampus by approximately 2-fold, 7days post-treatment.
Structural insights into the regulation of aromatic amino acid hydroxylation.
Review
New
Fitzpatrick, San Antonio, United States. In Curr Opin Struct Biol, Dec 2015
The aromatic amino acid hydroxylases phenylalanine hydroxylase, tyrosine hydroxylase, and tryptophan hydroxylase are homotetramers, with each subunit containing a homologous catalytic domain and a divergent regulatory domain.
The profile of melatonin receptors gene expression and genes associated with their activity in colorectal cancer: a preliminary report.
New
Muc-Wierzgoń et al., Bytom, Poland. In J Biol Regul Homeost Agents, Oct 2015
Among the genes participating in the cascade of signal transfer in cells activated by MLT via melatonin receptors, we found encoding genes (GNA11, OXTR, TPH1) only for differentiating stage III - IV of CRC.
Inhibiting peripheral serotonin synthesis reduces obesity and metabolic dysfunction by promoting brown adipose tissue thermogenesis.
New
Impact
Steinberg et al., Hamilton, Canada. In Nat Med, Feb 2015
Serotonin (5-hydroxytryptamine, 5-HT) is a highly conserved biogenic amine that resides in non-neuronal and neuronal tissues that are specifically regulated via tryptophan hydroxylase 1 (Tph1) and Tph2, respectively.
Clinical Syndromes Related to Gastrointestinal Neuroendocrine Neoplasms.
Review
Kaltsas et al., Athens, Greece. In Front Horm Res, 2014
Telotristat etiprate is a novel oral agent that inhibits tryptophan hydroxylase, the key enzyme responsible for serotonin production, and can improve the symptoms of CS.
Serotonergic gene variation in substance use pharmacotherapy: a systematic review.
Review
Nielsen et al., Houston, United States. In Pharmacogenomics, 2014
Current evidence suggests that genetic variability of the serotonergic biosynthesis enzyme tryptophan hydroxylase 2 (TPH2) and the serotonin transporter (SLC6A4) genes mediates the efficacy of several addiction treatments, such as ondansetron and disulfiram, and the antidepressants bupropion, nortriptyline and sertraline.
SERT and TPH-1 mRNA expression are reduced in irritable bowel syndrome patients regardless of visceral sensitivity state in large intestine.
GeneRIF
Samsom et al., Utrecht, Netherlands. In Am J Physiol Gastrointest Liver Physiol, 2012
In conclusion, regardless of visceral hypersensitivity state, several serotonergic signaling components are altered in IBS patients.
Effect of tryptophan hydroxylase gene polymorphism on aggression in major depressive disorder and undifferentiated somatoform disorder.
GeneRIF
Seo et al., Seoul, South Korea. In J Clin Psychiatry, 2012
Aggression in MDD patients is more susceptible to an excess of TPH1 CC homozygote than in undifferentiated somatoform disorder patients. TPH1 gene is most likely to have a shared effect on aggression and MDD.
Interaction between tryptophan hydroxylase I polymorphisms and childhood abuse is associated with increased risk for borderline personality disorder in adulthood.
GeneRIF
Mann et al., New York City, United States. In Psychiatr Genet, 2012
Variation in TPH1 may increase risk for developing borderline personality disorder as a result of childhood abuse.
The relation of serotonin-related gene and COMT gene polymorphisms with criminal behavior in schizophrenic disorder.
GeneRIF
Lee et al., Seoul, South Korea. In J Clin Psychiatry, 2012
results indicate that the TPH1 CC recessive genotype is likely to be a genetic risk factor for criminal behavior, especially homicidal behavior in patients with schizophrenia.
Association of variations in TPH1 and HTR2B with gestational weight gain and measures of obesity.
GeneRIF
Park et al., Seoul, South Korea. In Obesity (silver Spring), 2012
In non-diabetic controls, SNPs of TPH1 were associated with waist circumference and BMI.
Molecular regulation of sexual preference revealed by genetic studies of 5-HT in the brains of male mice.
Impact
Rao et al., Beijing, China. In Nature, 2011
A role for 5-HT was demonstrated by the phenotype of mice lacking tryptophan hydroxylase 2 (Tph2), which is required for the first step of 5-HT synthesis in the brain.
Serotonin regulates pancreatic beta cell mass during pregnancy.
Impact
German et al., San Francisco, United States. In Nat Med, 2010
Expression of serotonin synthetic enzyme tryptophan hydroxylase-1 (Tph1) and serotonin production rose sharply in beta cells during pregnancy or after treatment with lactogens in vitro.
Pharmacological inhibition of gut-derived serotonin synthesis is a potential bone anabolic treatment for osteoporosis.
Impact
Ducy et al., New York City, United States. In Nat Med, 2010
We synthesized and used LP533401, a small molecule inhibitor of tryptophan hydroxylase-1 (Tph-1), the initial enzyme in GDS biosynthesis.
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