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Tryptase alpha/beta 1

tryptase
Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, alpha and beta 1. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: MAST, CAN, HAD, IgE, chymase
Papers using tryptase antibodies
Ameliorative effect of pyrrolidinedithiocarbamate on acetic acid-induced colitis in rats
Supplier
Yang Ping-Chang et al., In North American Journal of Medical Sciences, 2006
... Anti-tryptase antibody (DAKO Diagnostics Canada, Mississauga, ON, ...
Amphotericin-B-mediated reactivationof latent HIV-1 infection
Supplier
Man Yan-gao et al., In International Journal of Biological Sciences, 2004
... A mouse monoclonal antibody (clone: AA1) against human mast cell tryptase was purchased from Dako (Giostrup, Denmark) ...
Papers on tryptase
Interaction of stromal and microvascular components in keratocystic odontogenic tumors.
New
Dos Santos et al., Salvador, Brazil. In J Oral Pathol Med, Feb 2016
MATERIAL AND METHODS: Thirty cases of KCOTs were included and analyzed by immunohistochemistry for mast cell tryptase, α-SMA, CD34, CD163, and D240.
IL-6 promotes an increase in human mast cell numbers and reactivity through suppression of suppressor of cytokine signaling 3.
New
Metcalfe et al., Bethesda, United States. In J Allergy Clin Immunol, Feb 2016
Serum samples from healthy control subjects and patients with mastocytosis were assayed for IL-6, tryptase, and sIL-6R.
Hymenoptera Allergy and Mast Cell Activation Syndromes.
Review
New
Zanotti et al., Verona, Italy. In Curr Allergy Asthma Rep, Jan 2016
A normal value of tryptase (≤11.4 ng/ml) in these patients does not exclude a diagnosis of mastocytosis.
Revisiting the role of the mast cell in asthma.
Review
New
Bjermer et al., Lund, Sweden. In Curr Opin Pulm Med, Jan 2016
RECENT FINDINGS: The heterogeneity of human mast cells has been recognized: MCTC expressing both tryptase and chymase and MCT expressing tryptase only.
Bone marrow tryptase as a possible diagnostic criterion for adult systemic mastocytosis.
New
Paul et al., Toulouse, France. In Clin Exp Allergy, Jan 2016
OBJECTIVE: The main objective was to evaluate the accuracy of the bone marrow tryptase level in the diagnosis of systemic mastocytosis in patients with a clinical suspicion of mastocytosis.
Cardiovascular symptoms in patients with systemic mast cell activation disease.
Review
New
Molderings et al., Bonn, Germany. In Transl Res, Jan 2016
UNASSIGNED: Traditionally, mast cell activation disease (MCAD) has been considered as just one rare (neoplastic) disease, mastocytosis, focused on the mast cell (MC) mediators tryptase and histamine and the suggestive, blatant symptoms of flushing and anaphylaxis.
Increased asthma and adipose tissue inflammatory gene expression with obesity and Inuit migration to a western country.
New
Gibson et al., Copenhagen, Denmark. In Respir Med, Jan 2016
Adipose tissue biopsies were homogenised, RNA extracted, and PCR was performed to determine the relative gene expression of mast cell (tryptase, chymase, CPA3) and inflammatory markers (IL-6, IL-1β, and CD163).
Morphometric analysis of inflammation in bronchial biopsies following exposure to inhaled diesel exhaust and allergen challenge in atopic subjects.
New
Carlsten et al., Vancouver, Canada. In Part Fibre Toxicol, Dec 2015
Biopsies sections were immunostained for tryptase, eosinophil cationic protein (ECP), neutrophil elastase (NE), CD138, CD4 and interleukin (IL)-4.
Targeting mast cells in gastric cancer with special reference to bone metastases.
Review
New
Ranieri et al., Catanzaro, Italy. In World J Gastroenterol, Nov 2015
Several lines of evidence from GC patients strongly support the involvement of mast cells (MCs) positive to tryptase (MCPT) in primary gastric tumor angiogenesis.
Allergen-induced asthmatic responses modified by a GATA3-specific DNAzyme.
New
Impact
Renz et al., Marburg an der Lahn, Germany. In N Engl J Med, Jun 2015
Inhibition of the late asthmatic response by SB010 was associated with attenuation of allergen-induced sputum eosinophilia and with lower levels of tryptase in sputum and lower plasma levels of interleukin-5.
An unusual tumour of the lung.
Review
New
Sellami-Boudawara et al., In Pathologica, Mar 2015
The neoplastic mast cells stained strongly with tryptase, CD117, CD68 and CD45, CD14 and CD33; whereas the undifferentiated cells lacked all these markers and expressed EMA and cytokeratin.
Multidimensional endotypes of asthma: topological data analysis of cross-sectional clinical, pathological, and immunological data.
New
Impact
Djukanović et al., Geretsried, Germany. In Lancet, Mar 2015
BNA and TDA identified six novel clinicopathobiological clusters of underlying disease mechanisms, with elevated mast cell mediators tryptase (p<0·0001), chymase (p=0·02), and carboxypeptidase A3 (p=0·02) in severe asthma.
Association of mast cell-derived VEGF and proteases in Dengue shock syndrome.
GeneRIF
Watanabe et al., Tokyo, Japan. In Plos Negl Trop Dis, 2011
As mast cells are an important source of VEGF, tryptase, and chymase, these findings suggest that mast cell activation and mast cell-derived mediators participate in the development of Dengue hemorrhagic fever.
Mast cell tryptase induces microglia activation via protease-activated receptor 2 signaling.
GeneRIF
He et al., Nanjing, China. In Cell Physiol Biochem, 2011
results suggest that tryptase can induce microglia activation and pro-inflammatory mediator release via PAR-2-MAPK-NF-kappa B signaling pathway, which will contribute to the development of microglia-mediated inflammation in brain
Mast cells in melanocytic skin lesions. An immunohistochemical and quantitative study.
GeneRIF
Pescarini et al., Kraków, Poland. In Pol J Pathol, 2011
Two different populations of mast cells were found in melanocytic skin; one expressing both chymase and tryptase and the other with tryptase only.
Mast cell tryptase stimulates myoblast proliferation; a mechanism relying on protease-activated receptor-2 and cyclooxygenase-2.
GeneRIF
Côté et al., Québec, Canada. In Bmc Musculoskelet Disord, 2010
Tryptase can stimulate myoblast proliferation and this effect is part of a signaling cascade dependent on PAR-2 activation and on the downstream activation of COX-2.
Immunoglobulin E and mast cell proteases are potential risk factors of human pre-diabetes and diabetes mellitus.
GeneRIF
Shi et al., Huzhou, China. In Plos One, 2010
Both IgE and chymase associate with diabetes status.
Proteinase-activated receptors: transducers of proteinase-mediated signaling in inflammation and immune response.
Review
Impact
Hollenberg et al., Münster, Germany. In Endocr Rev, 2005
Serine proteinases such as thrombin, mast cell tryptase, trypsin, or cathepsin G, for example, are highly active mediators with diverse biological activities.
Mast cell-derived tumor necrosis factor induces hypertrophy of draining lymph nodes during infection.
Impact
Abraham et al., Durham, United States. In Nat Immunol, 2003
Testing of individual mast cell-derived products in this model indicated that tumor necrosis factor was the main mediator of nodal hypertrophy, whereas tryptase and histamine had no effect.
Mast-cell infiltration of airway smooth muscle in asthma.
Impact
Pavord et al., Leicester, United Kingdom. In N Engl J Med, 2002
By contrast, the number of tryptase-positive mast cells in the bundles of airway smooth muscle from subjects with asthma (median, 5.1 mast cells per square millimeter of smooth muscle [range, 0 to 33.3]) was substantially higher than that in subjects with eosinophilic bronchitis (median, 0 mast cells per square millimeter; range, 0 to 4.8) and that in normal controls (median, 0 mast cells per square millimeter [range, 0 to 6.4]; P<0.001 for the comparison among the three groups).
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