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Transient receptor potential cation channel, subfamily V, member 6

TRPV6, C at, CaT1
This gene encodes a member of the vanilloid family of transient receptor potential (TRP) calcium channel proteins. Proteins in this TRP family have an N-terminal ankyrin repeat domain, which is required for channel assembly and regulation. [provided by RefSeq, Nov 2011] (from NCBI)
Top mentioned proteins: TRPV5, ACID, catalase, D28k, HAD
Papers using TRPV6 antibodies
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.
Obukhov Alexander G., In PLoS ONE, 2000
... For immunohistological studies a goat polyclonal IgG against TRPV6 (sc-31445) was purchased from Santa Cruz Biotechnology, USA, and a horseradish peroxidase-conjugated ...
Papers on TRPV6
Uptake of manganese from manganese-lysine complex in the primary rat intestinal epithelial cells.
Bai et al., China. In J Anim Physiol Anim Nutr (berl), Jan 2016
The MnLys increased (p < 0.01) the system y(+) member cationic amino acid transporter (CAT) 1, and system b(0,+) components rBAT and b(0,+) AT mRNA expression when compared to MnSO4 .
USP2-45 Is a Circadian Clock Output Effector Regulating Calcium Absorption at the Post-Translational Level.
Staub et al., Lausanne, Switzerland. In Plos One, Dec 2015
Usp2-KO mice show hyperabsorption of dietary Ca2+ in small intestine, likely due to strong overexpression of the membrane scaffold protein NHERF4, a regulator of the Ca2+ channel TRPV6 mediating dietary Ca2+ uptake.
Intestinal mucosal changes and upregulated calcium transporter and FGF-23 expression during lactation: Contribution of lactogenic hormone prolactin.
Charoenphandhu et al., Bangkok, Thailand. In Arch Biochem Biophys, Dec 2015
PRL also upregulated calcium transporter expression (e.g., TRPV6 and PMCA1b) in the duodenum of lactating rats.
The role of calbindin-D28k on renal calcium and magnesium handling during treatment with loop or thiazide diuretics.
Lien et al., Dschang, Cameroon. In Am J Physiol Renal Physiol, Dec 2015
DCT Ca transport molecules including TRPV5, TRPV6 and CBD-9k were upregulated by CTZ and FSM in WT, but not in KO mice.
Expression of small intestinal nutrient transporters in embryonic and posthatch turkeys.
Wong et al., Edinburgh, United Kingdom. In Poult Sci, Dec 2015
Real-time PCR was used to determine expression of aminopeptidase N (APN), one peptide (PepT1), 6 amino acid (ASCT1, b(o,+)AT, CAT1, EAAT3, LAT1, y(+)LAT2) and 3 monosaccharide (GLUT2, GLUT5, SGLT1) transporters.
Real-time functional characterization of cationic amino acid transporters using a new FRET sensor.
Verrey et al., Zürich, Switzerland. In Pflugers Arch, Dec 2015
By expressing the nanosensor together with SLC7A1, SLC7A2B, or SLC7A3 cationic amino acid transporters (CAT1-3), it was shown that L-arginine was imported at a similar rate via SLC7A1 and SLC7A2B and slower via SLC7A3.
[The role of gastro-intestinal tract in the calcium absorption].
Tanaka et al., Ōsaka, Japan. In Clin Calcium, Nov 2015
For the former, such molecules as transient receptor potential vanilloid type 6(TRPV6), calbindin 9k, and Ca²⁺-ATPase contribute.
Calcium transport in bovine rumen epithelium as affected by luminal Ca concentrations and Ca sources.
Breves et al., Hannover, Germany. In Physiol Rep, Nov 2015
Standard RT-PCR method was used to characterize TRPV6 and PMCA1 as potential contributors to transepithelial active Ca transport.
Pathogenesis and treatment of the cardiorenal syndrome: Implications of L-arginine-nitric oxide pathway impairment.
Kaye et al., Melbourne, Australia. In Pharmacol Ther, Oct 2015
The synthesis of NO by the endothelium is critically dependent on the plasmalemmal transport of its substrate, L-arginine, via the cationic amino acid transporter-1 (CAT1).
Molecular aspects of intestinal calcium absorption.
Tolosa de Talamoni et al., Córdoba, Argentina. In World J Gastroenterol, Jul 2015
The first route comprises 3 steps: the entrance of Ca(2+) across the brush border membranes (BBM) of enterocytes through epithelial Ca(2+) channels TRPV6, TRPV5, and Cav1.3;
Fluid shear triggers microvilli formation via mechanosensitive activation of TRPV6.
Takeuchi et al., Tokyo, Japan. In Nat Commun, 2014
We further reveal that the transient receptor potential, vanilloid family type-6 (TRPV6) calcium ion channel plays a critical role in flow-induced Ca(2+) influx and microvilli formation.
The transient receptor potential cation channel subfamily V member 6 (TRPV6): genetics, biochemical properties, and functions of exceptional calcium channel proteins.
Flockerzi et al., Homburg, Germany. In Biochem Cell Biol, 2014
The transient receptor potential cation channel subfamily V member 6 (TRPV6) gene and cDNA were identified 15 years ago and exceptional observations on TrpV6 proteins and their function as a Ca(2+)-selective cation channel have been made since then.
TRPV6 channels.
Wissenbach et al., Homburg, Germany. In Handb Exp Pharmacol, 2013
TRPV6 (former synonyms ECAC2, CaT1, CaT-like) displays several specific features which makes it unique among the members of the mammalian Trp gene family (1) TRPV6 (and its closest relative, TRPV5) are the only highly Ca(2+)-selective channels of the entire TRP superfamily (Peng et al. 1999; Wissenbach et al. 2001; Voets et al. 2004).
The TRPV5/6 calcium channels contain multiple calmodulin binding sites with differential binding properties.
Vuister et al., Nijmegen, Netherlands. In J Struct Funct Genomics, 2012
The TRPV6 is a close homolog of TRPV5, yet their calmodulin binding sites display diversity in binding modes, binding stoichiometries and binding affinities which may fine-tune the response of the channels to varying Ca(2+)-concentrations.
Excision of Trpv6 gene leads to severe defects in epididymal Ca2+ absorption and male fertility much like single D541A pore mutation.
Freichel et al., Homburg, Germany. In J Biol Chem, 2012
Trpv6 excision affects epididymal Ca(2+) handling and male fertility to the same extent as the introduction of the D541A pore mutation, arguing against residual functions of the TRPV6(D541A) pore mutant in epididymal epithelial cells
Suppression of intestinal calcium entry channel TRPV6 by OCRL, a lipid phosphatase associated with Lowe syndrome and Dent disease.
Peng et al., Birmingham, United States. In Am J Physiol Cell Physiol, 2012
Knocking down endogenous OCRL by antisense approach increased TRPV6-mediated Ca(2+) transport and TRPV6 forward trafficking.
Calcium transport genes are differently regulated in maternal and fetal placenta in the knockout mice of calbindin-D(9k) and -D(28k).
Jeung et al., Ch'ŏngju, South Korea. In Mol Reprod Dev, 2012
TRPV6, NCX1, and CaBP-9k in the fetal placenta and CaBP-28k in the maternal placenta may play key roles in controlling calcium transport across the placenta during pregnancy.
The transient receptor potential ion channel TRPV6 is expressed at low levels in osteoblasts and has little role in osteoblast calcium uptake.
Grabowski et al., Sheffield, United Kingdom. In Plos One, 2010
Data show that the transient receptor potential ion channel TRPV6 is expressed only at low levels in osteoblasts and plays little functional role in osteoblastic calcium uptake.
Calcium absorption across epithelia.
Bindels et al., Nijmegen, Netherlands. In Physiol Rev, 2005
A major breakthrough in completing the molecular details of these pathways was the identification of the epithelial Ca(2+) channel family consisting of two members: TRPV5 and TRPV6.
CaT1 manifests the pore properties of the calcium-release-activated calcium channel.
Clapham et al., Boston, United States. In Nature, 2001
Here we show that the protein CaT1 (ref.
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