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Transient receptor potential cation channel, subfamily V, member 6

TRPV6, C at, CaT1
This gene encodes a member of the vanilloid family of transient receptor potential (TRP) calcium channel proteins. Proteins in this TRP family have an N-terminal ankyrin repeat domain, which is required for channel assembly and regulation. [provided by RefSeq, Nov 2011] (from NCBI)
Papers using TRPV6 antibodies
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.
Obukhov Alexander G., In PLoS ONE, 2000
... For immunohistological studies a goat polyclonal IgG against TRPV6 (sc-31445) was purchased from Santa Cruz Biotechnology, USA, and a horseradish peroxidase-conjugated ...
Papers on TRPV6
The TRPV5/6 calcium channels contain multiple calmodulin binding sites with differential binding properties.
Vuister et al., Nijmegen, Netherlands. In J Struct Funct Genomics, 2012
The TRPV6 is a close homolog of TRPV5, yet their calmodulin binding sites display diversity in binding modes, binding stoichiometries and binding affinities which may fine-tune the response of the channels to varying Ca(2+)-concentrations.
Excision of Trpv6 gene leads to severe defects in epididymal Ca2+ absorption and male fertility much like single D541A pore mutation.
Freichel et al., Homburg, Germany. In J Biol Chem, 2012
Trpv6 excision affects epididymal Ca(2+) handling and male fertility to the same extent as the introduction of the D541A pore mutation, arguing against residual functions of the TRPV6(D541A) pore mutant in epididymal epithelial cells
Suppression of intestinal calcium entry channel TRPV6 by OCRL, a lipid phosphatase associated with Lowe syndrome and Dent disease.
Peng et al., Birmingham, United States. In Am J Physiol Cell Physiol, 2012
Knocking down endogenous OCRL by antisense approach increased TRPV6-mediated Ca(2+) transport and TRPV6 forward trafficking.
Calcium transport genes are differently regulated in maternal and fetal placenta in the knockout mice of calbindin-D(9k) and -D(28k).
Jeung et al., Ch'ŏngju, South Korea. In Mol Reprod Dev, 2012
TRPV6, NCX1, and CaBP-9k in the fetal placenta and CaBP-28k in the maternal placenta may play key roles in controlling calcium transport across the placenta during pregnancy.
The transient receptor potential ion channel TRPV6 is expressed at low levels in osteoblasts and has little role in osteoblast calcium uptake.
Grabowski et al., Sheffield, United Kingdom. In Plos One, 2010
Data show that the transient receptor potential ion channel TRPV6 is expressed only at low levels in osteoblasts and plays little functional role in osteoblastic calcium uptake.
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