PTH modulation of NCC activity regulates TRPV5 Ca2+ reabsorption.
Atlanta, United States. In Am J Physiol Renal Physiol, Feb 2016
Since parathyroid hormone (PTH) is known to increase transient receptor potential vanilloid (TRPV)5 activity and decrease Na(+)-Cl(-) cotransporter (NCC) activity, we hypothesized that decreased NCC-mediated Na(+) reabsorption contributes to the enhanced TRPV5 Ca(2+) reabsorption seen with PTH.
FGF23 regulation of renal tubular solute transport.
Vienna, Austria. In Curr Opin Nephrol Hypertens, Sep 2015
By targeting WNK4, FGF23 has been shown to increase the membrane abundance of the epithelial calcium channel TRPV5 and of the sodium-chloride cotransporter NCC, resulting in augmented renal calcium and sodium reabsorption.
Molecular aspects of intestinal calcium absorption.
Córdoba, Argentina. In World J Gastroenterol, Jul 2015
The first route comprises 3 steps: the entrance of Ca(2+) across the brush border membranes (BBM) of enterocytes through epithelial Ca(2+) channels TRPV6, TRPV5, and Cav1.3;
Nucleoside diphosphate kinase as protein histidine kinase.
Crawley, United Kingdom. In Naunyn Schmiedebergs Arch Pharmacol, Feb 2015
Especially for the isoform NDPK B, at least three defined substrates, the β subunit of heterotrimeric G proteins (Gβ), the intermediate conductance potassium channel KCa3.1, and the Ca(2+)-conducting TRP channel family member, TRPV5, have been identified.
Vitamin D-enhanced duodenal calcium transport.
Thailand. In Vitam Horm, 2014
After binding to the nuclear vitamin D receptor, 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] upregulates the expression of several calcium transporter genes, e.g., TRPV5/6, calbindin-D9k, plasma membrane Ca(2+)-ATPase1b, and NCX1, thereby enhancing the transcellular calcium transport.
(Patho)physiological significance of the serum- and glucocorticoid-inducible kinase isoforms.
Tübingen, Germany. In Physiol Rev, 2006
SGKs activate ion channels (e.g., ENaC, TRPV5, ROMK, Kv1.3, KCNE1/KCNQ1, GluR1, GluR6), carriers (e.g., NHE3, GLUT1, SGLT1, EAAT1-5), and the Na+-K+-ATPase.
Calcium absorption across epithelia.
Nijmegen, Netherlands. In Physiol Rev, 2005
A major breakthrough in completing the molecular details of these pathways was the identification of the epithelial Ca(2+) channel family consisting of two members: TRPV5 and TRPV6.
Transporters for cationic amino acids in animal cells: discovery, structure, and function.
Santiago, Chile. In Physiol Rev, 1998
In the CAT family, three genes encode for four different isoforms [CAT-1, CAT-2A, CAT-2(B) and CAT-3]; these are approximately 70-kDa proteins with multiple transmembrane segments (12-14), and despite their structural similarity, they differ in tissue distribution, kinetics, and regulatory properties.