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Transient receptor potential cation channel, subfamily V, member 5

TRPV5, Cat2, Cationic Amino Acid Transporter 2
This gene is a member of the transient receptor family and the TrpV subfamily. The calcium-selective channel encoded by this gene has 6 transmembrane-spanning domains, multiple potential phosphorylation sites, an N-linked glycosylation site, and 5 ANK repeats. This protein forms homotetramers or heterotetramers and is activated by a low internal calcium level. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: TRPV6, catalase, ACID, V1a, CAN
Papers on TRPV5
PTH modulation of NCC activity regulates TRPV5 Ca2+ reabsorption.
Ko et al., Atlanta, United States. In Am J Physiol Renal Physiol, Feb 2016
Since parathyroid hormone (PTH) is known to increase transient receptor potential vanilloid (TRPV)5 activity and decrease Na(+)-Cl(-) cotransporter (NCC) activity, we hypothesized that decreased NCC-mediated Na(+) reabsorption contributes to the enhanced TRPV5 Ca(2+) reabsorption seen with PTH.
Urinary β-galactosidase stimulates Ca2+ transport by stabilizing TRPV5 at the plasma membrane.
Hoenderop et al., Nijmegen, Netherlands. In Glycobiology, Feb 2016
UNASSIGNED: Transcellular Ca(2+) transport in the late distal convoluted tubule and connecting tubule (DCT2/CNT) of the kidney is a finely controlled process mediated by the transient receptor potential vanilloid type 5 (TRPV5) channel.
The role of calbindin-D28k on renal calcium and magnesium handling during treatment with loop or thiazide diuretics.
Lien et al., Dschang, Cameroon. In Am J Physiol Renal Physiol, Dec 2015
DCT Ca transport molecules including TRPV5, TRPV6 and CBD-9k were upregulated by CTZ and FSM in WT, but not in KO mice.
[Effect of Zhibai Dihuang Decoction on Expressions of TRPV1 and TRPV5 in Spermatogenic Cells of UU-infected Rats].
Liu et al., In Zhongguo Zhong Xi Yi Jie He Za Zhi, Oct 2015
OBJECTIVE: To observe the effect of Zhibai Dihuang Decoction (ZDD) on mRNA and protein expressions of transient receptor potential family vanilloid subtype 1 (TRPV1) and transient receptor potential family vanilloid subtype 5 (TRPV5) in Ureaplasma urealyticum (UU)-infected rat semens and spermatogenic cells, and to explore the pathomechanism of UU-infected infertility and the intervention of ZDD.
FGF23 regulation of renal tubular solute transport.
Andrukhova et al., Vienna, Austria. In Curr Opin Nephrol Hypertens, Sep 2015
By targeting WNK4, FGF23 has been shown to increase the membrane abundance of the epithelial calcium channel TRPV5 and of the sodium-chloride cotransporter NCC, resulting in augmented renal calcium and sodium reabsorption.
Molecular aspects of intestinal calcium absorption.
Tolosa de Talamoni et al., Córdoba, Argentina. In World J Gastroenterol, Jul 2015
The first route comprises 3 steps: the entrance of Ca(2+) across the brush border membranes (BBM) of enterocytes through epithelial Ca(2+) channels TRPV6, TRPV5, and Cav1.3;
Nucleoside diphosphate kinase as protein histidine kinase.
Wieland et al., Crawley, United Kingdom. In Naunyn Schmiedebergs Arch Pharmacol, Feb 2015
Especially for the isoform NDPK B, at least three defined substrates, the β subunit of heterotrimeric G proteins (Gβ), the intermediate conductance potassium channel KCa3.1, and the Ca(2+)-conducting TRP channel family member, TRPV5, have been identified.
Vitamin D-enhanced duodenal calcium transport.
Charoenphandhu et al., Thailand. In Vitam Horm, 2014
After binding to the nuclear vitamin D receptor, 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] upregulates the expression of several calcium transporter genes, e.g., TRPV5/6, calbindin-D9k, plasma membrane Ca(2+)-ATPase1b, and NCX1, thereby enhancing the transcellular calcium transport.
Alterations in reversible protein histidine phosphorylation as intracellular signals in cardiovascular disease.
Attwood et al., Mannheim, Germany. In Front Pharmacol, 2014
At least three well defined substrates of NDPK-B are known: The β-subunit of heterotrimeric G-proteins (Gβ), the intermediate conductance potassium channel SK4 and the Ca(2+) conducting TRP channel family member, TRPV5.
A chimera carrying the functional domain of the orphan protein SLC7A14 in the backbone of SLC7A2 mediates trans-stimulated arginine transport.
Closs et al., Mainz, Germany. In J Biol Chem, 2012
A chimera carrying the functional domain of the orphan protein SLC7A14 in the backbone of SLC7A2 mediates trans-stimulated arginine transport.
The TRPV5/6 calcium channels contain multiple calmodulin binding sites with differential binding properties.
Vuister et al., Nijmegen, Netherlands. In J Struct Funct Genomics, 2012
The TRPV6 is a close homolog of TRPV5, yet their calmodulin binding sites display diversity in binding modes, binding stoichiometries and binding affinities which may fine-tune the response of the channels to varying Ca(2+)-concentrations.
Treatment outcome and mortality: Their predictors among HIV/TB co-infected patients from Iran.
Mansouri et al., Tehrān, Iran. In Int J Mycobacteriol, 2012
The route of transmission of HIV was intravenous drug use in 88 of the patients (79.3%); 23 patients (20.7%) had a history of Category 1 (CAT-1) (5.4%) and CAT-2 treatment.
L-arginine uptake by cationic amino acid transporter 2 is essential for colonic epithelial cell restitution.
Wilson et al., Nashville, United States. In Am J Physiol Gastrointest Liver Physiol, 2012
Uptake of L-Arg, and its metabolism by Arg1 to L-Orn and conversion to L-Pro by OAT is essential for colonic epithelial wound repair.
GIT2 acts as a potential keystone protein in functional hypothalamic networks associated with age-related phenotypic changes in rats.
Maudsley et al., Baltimore, United States. In Plos One, 2011
potentially identified the G protein-coupled receptor/cytoskeletal-associated protein GIT2 as a vital integrator and modulator of the normal aging process
Cationic amino acid transporter 2 enhances innate immunity during Helicobacter pylori infection.
Wilson et al., Nashville, United States. In Plos One, 2010
CAT2 is an important regulator of the immune response during H. pylori infection.
(Patho)physiological significance of the serum- and glucocorticoid-inducible kinase isoforms.
Vallon et al., Tübingen, Germany. In Physiol Rev, 2006
SGKs activate ion channels (e.g., ENaC, TRPV5, ROMK, Kv1.3, KCNE1/KCNQ1, GluR1, GluR6), carriers (e.g., NHE3, GLUT1, SGLT1, EAAT1-5), and the Na+-K+-ATPase.
Regulating gene expression through RNA nuclear retention.
Spector et al., New York City, United States. In Cell, 2005
CTN-RNA is transcribed from the protein-coding mouse cationic amino acid transporter 2 (mCAT2) gene through alternative promoter and poly(A) site usage.
The beta-glucuronidase klotho hydrolyzes and activates the TRPV5 channel.
Hoenderop et al., Nijmegen, Netherlands. In Science, 2005
TRPV5 is stimulated by klotho; klotho hydrolyzes extracellular sugar residues on TRPV5, entrapping the channel in the plasma membrane
Calcium absorption across epithelia.
Bindels et al., Nijmegen, Netherlands. In Physiol Rev, 2005
A major breakthrough in completing the molecular details of these pathways was the identification of the epithelial Ca(2+) channel family consisting of two members: TRPV5 and TRPV6.
Transporters for cationic amino acids in animal cells: discovery, structure, and function.
Boyd et al., Santiago, Chile. In Physiol Rev, 1998
In the CAT family, three genes encode for four different isoforms [CAT-1, CAT-2A, CAT-2(B) and CAT-3]; these are approximately 70-kDa proteins with multiple transmembrane segments (12-14), and despite their structural similarity, they differ in tissue distribution, kinetics, and regulatory properties.
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