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Transient receptor potential cation channel, subfamily V, member 4

TRPV4, Trp12
This gene encodes a member of the OSM9-like transient receptor potential channel (OTRPC) subfamily in the transient receptor potential (TRP) superfamily of ion channels. The encoded protein is a Ca2+-permeable, nonselective cation channel that is thought to be involved in the regulation of systemic osmotic pressure. Mutations in this gene are the cause of spondylometaphyseal and metatropic dysplasia and hereditary motor and sensory neuropathy type IIC. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010] (from NCBI)
Top mentioned proteins: TRPV1, CAN, ACID, V1a, TRPV2
Papers using TRPV4 antibodies
Physiological roles of TRPV2 expressed in the olfactory axon
Supplier
Hirakawa Katsuhiro et al., In Acta Oto-Laryngologica, 2006
... antibody to TRPV3 (Santa Cruz Biotechnology Inc, CA, USA) (diluted 1:50), a rabbit polyclonal antibody to TRPV4 (Alomone Labs Ltd, Jerusalem, Israel) (diluted ...
Myosin Vb interacts with Rab8a on a tubular network containing EHD1 and EHD3.
Supplier
Ulrich Henning, In PLoS ONE, 2006
... The recombinant TRPV4-mCerulean and TRPV4-mVenus proteins were also characterized by western blots using both anti-TRPV4 antibody (Alomone Labs, Jerusalem, Israel) and anti-GFP ...
Homo- and heteromeric assembly of TRP channel subunits
Supplier
Gaudet Rachelle et al., In Biochemistry, 2004
... TRPV4 as osmosensor: A transgenic approach ...
Papers on TRPV4
Data-driven Analysis of TRP Channels in Cancer: Linking Variation in Gene Expression to Clinical Significance.
New
Shin et al., Seoul, South Korea. In Cancer Genomics Proteomics, Feb 2016
TRPV4 and TRPA1 were found up- and down-regulated respectively in a cancer type-specific manner.
The functions of TRPP2 in the vascular system.
Review
New
Shen et al., Hefei, China. In Acta Pharmacol Sin, Jan 2016
In cell membrane, TRPP2, along with polycystin-1, TRPV4 and TRPC1, functions as a mechanotransduction channel.
Involvement of TRPV4 in Serotonin-Evoked Scratching.
New
Carstens et al., Davis, United States. In J Invest Dermatol, Jan 2016
In contrast, the role of transient receptor potential vanilloid type-4 (TRPV4) in itch is unknown.
An Unexpected Role for TRPV4 in Serotonin-Mediated Itch.
New
Ross et al., Pittsburgh, United States. In J Invest Dermatol, Jan 2016
Although other TRP channels, such as TRPV4, are expressed in primary afferents, whether or not they play an analogous role in itch was previously unknown.
Anthropogenic Radio-Frequency Electromagnetic Fields Elicit Neuropathic Pain in an Amputation Model.
New
Romero-Ortega et al., Arlington, United States. In Plos One, Dec 2015
Furthermore, immunofluorescence revealed an increased expression of temperature sensitive cation channels (TRPV4) in the neuroma bulb, suggesting that RF EMF-induced pain may be due to cytokine-mediated channel dysregulation and hypersensitization, leading to thermal allodynia.
Physiological role of aquaporin 5 in salivary glands.
Review
New
Hosoi, Tokushima, Japan. In Pflugers Arch, Dec 2015
First, the involvement of AQP5 in water secretion from acinar cells was demonstrated by measuring volume changes of acini/acinar cells, as well as activation energy (E a) in transepithelial water movement by NMR spectrometry, and a functional linkage between AQP5 and TRPV4 was suggested.
TRPV4 channels: physiological and pathological role in cardiovascular system.
Review
New
Jaggi et al., Patiāla, India. In Basic Res Cardiol, Nov 2015
TRPV4 channels are non-selective cation channels permeable to Ca(2+), Na(+), and Mg(2+) ions.
[Research progress of TRPV4 and cerebral ischemic reperfusion injury].
Review
New
Chen et al., Nanjing, China. In Sheng Li Xue Bao, Nov 2015
Transient receptor potential vanilloid 4 (TRPV4) channel is a member of transient receptor potential superfamily.
An intelligent nano-antenna: Primary cilium harnesses TRP channels to decode polymodal stimuli.
Review
New
Inoue et al., Baltimore, United States. In Cell Calcium, Oct 2015
Each subfamily member, namely TRPP2 TRPP3, TRPC1 and TRPV4, is gated by multiple environmental factors, including chemical (receptor ligands, intracellular second messengers such as Ca(2+)), mechanical (fluid shear stress, hypo-osmotic swelling), or physical (temperature, voltage) stimuli.
Yiqi Huayu recipe relieves nerve root constriction induced radicular neuralgia by down-regulating TRPV4 expression in dorsal root ganglion.
Shi et al., Shanghai, China. In Int J Clin Exp Med, 2014
The aim of this study was to observe the effects of Yiqi Huayu recipe on TRPV4 expression in radicular neuralgia model induced by chronic constriction to the rat lumber nerve root.
TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis.
Impact
Spiegelman et al., Boston, United States. In Cell, 2012
In particular, TRPV4 negatively regulated the expression of PGC1α, UCP1, and cellular respiration.
A novel zebrafish model of hyperthermia-induced seizures reveals a role for TRPV4 channels and NMDA-type glutamate receptors.
GeneRIF
Baraban et al., San Francisco, United States. In Exp Neurol, 2012
Age-dependence of heat-activated seizure susceptibility mimicks the mRNA expression of TRPV4 and glutamate receptors.
Vascular hypoxic preconditioning relies on TRPV4-dependent calcium influx and proper intercellular gap junctions communication.
GeneRIF
Dessy et al., Brussels, Belgium. In Arterioscler Thromb Vasc Biol, 2012
TRPV4 and connexins might participate in preserving vasorelaxation under hypoxia and restoring the NO-mediated pathway in hypoxic preconditioning conditions.
Exome sequencing identifies a novel TRPV4 mutation in a CMT2C family.
GeneRIF
Sumner et al., United States. In Neurology, 2012
A novel TRPV4 mutation is identified by exome sequencing in a family with Charcot-Marie-tooth disease type 2.
TRPV4 axonal neuropathy spectrum disorder.
Review
GeneRIF
McEntagart, London, United Kingdom. In J Clin Neurosci, 2012
Mutations in TRPV4 were implicated in a family of short-stature skeletal dysplasias.
Mutations in the TRPV4 gene are not associated with sporadic progressive muscular atrophy.
GeneRIF
van den Berg et al., In Arch Neurol, 2012
The results of this study demonistrated that the Mutations in the TRPV4 gene are not associated with sporadic progressive muscular atrophy.
Elementary Ca2+ signals through endothelial TRPV4 channels regulate vascular function.
Impact
GeneRIF
Nelson et al., Burlington, United States. In Science, 2012
results support the concept that Ca(2 ) influx through single TRPV4 channels is leveraged by the amplifier effect of cooperative channel gating and the high Ca(2 ) sensitivity of IK and SK channels to cause vasodilation
Mutations in TRPV4 cause an inherited arthropathy of hands and feet.
Impact
GeneRIF
Bateman et al., Melbourne, Australia. In Nat Genet, 2011
data indicate TRPV4 mutations that reduce channel activity cause inherited osteoarthropathy and show importance of TRPV4 activity in articular cartilage homeostasis; data raise possibility TRPV4 may have a role in age- or injury-related osteoarthritis
Alterations in the ankyrin domain of TRPV4 cause congenital distal SMA, scapuloperoneal SMA and HMSN2C.
Impact
GeneRIF
Guelly et al., Graz, Austria. In Nat Genet, 2010
Mutations in the TRPV4 gene cause congenital distal Spinal muscular atrophies (SMA), scapuloperoneal Spinal muscular atrophies, hereditary motor and sensory neuropathies 2C.
Channelopathies converge on TRPV4.
Impact
Owsianik et al., In Nat Genet, 2010
Three new studies demonstrate that they are allelic disorders caused by mutations in the vanilloid transient receptor potential cation-channel gene TRPV4.
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