Physiological role of aquaporin 5 in salivary glands.
Tokushima, Japan. In Pflugers Arch, Dec 2015
First, the involvement of AQP5 in water secretion from acinar cells was demonstrated by measuring volume changes of acini/acinar cells, as well as activation energy (E a) in transepithelial water movement by NMR spectrometry, and a functional linkage between AQP5 and TRPV4 was suggested.
An intelligent nano-antenna: Primary cilium harnesses TRP channels to decode polymodal stimuli.
Baltimore, United States. In Cell Calcium, Oct 2015
Each subfamily member, namely TRPP2 TRPP3, TRPC1 and TRPV4, is gated by multiple environmental factors, including chemical (receptor ligands, intracellular second messengers such as Ca(2+)), mechanical (fluid shear stress, hypo-osmotic swelling), or physical (temperature, voltage) stimuli.
Mutations in TRPV4 cause an inherited arthropathy of hands and feet.
Melbourne, Australia. In Nat Genet, 2011
data indicate TRPV4 mutations that reduce channel activity cause inherited osteoarthropathy and show importance of TRPV4 activity in articular cartilage homeostasis; data raise possibility TRPV4 may have a role in age- or injury-related osteoarthritis
Channelopathies converge on TRPV4.
In Nat Genet, 2010
Three new studies demonstrate that they are allelic disorders caused by mutations in the vanilloid transient receptor potential cation-channel gene TRPV4.