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Transient receptor potential cation channel, subfamily V, member 3

TRPV3
This gene product belongs to a family of nonselective cation channels that function in a variety of processes, including temperature sensation and vasoregulation. The thermosensitive members of this family are expressed in subsets of sensory neurons that terminate in the skin, and are activated at distinct physiological temperatures. This channel is activated at temperatures between 22 and 40 degrees C. This gene lies in close proximity to another family member (TRPV1) gene on chromosome 17, and the two encoded proteins are thought to associate with each other to form heteromeric channels. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: TRPV1, TRPV4, TRPV2, TRPM8, TRPA1
Papers using TRPV3 antibodies
Physiological roles of TRPV2 expressed in the olfactory axon
Supplier
Hirakawa Katsuhiro et al., In Acta Oto-Laryngologica, 2006
... mg/ml), rabbit polyclonal antibody to TRPV2 (abcam, Tokyo, Japan) (diluted 1:1000), goat polyclonal antibody to TRPV3 (Santa Cruz Biotechnology Inc, CA, USA) (diluted ...
Papers on TRPV3
TRPV3 channels mediate Ca(2+) influx induced by 2-APB in mouse eggs.
New
Carvacho et al., Amherst Center, United States. In Cell Calcium, Jan 2016
The TRP Ca(2+) channel TRPV3 is differentially expressed during oocyte maturation, being most active at the MII stage.
P2Y1 Receptor Activation of the TRPV4 Ion Channel Enhances Purinergic Signaling in Satellite Glial Cells.
New
Veldhuis et al., Melbourne, Australia. In J Biol Chem, Dec 2015
SGCs did not express functional TRPV1, TRPV3, or TRP ankyrin 1 channels.
The Xenopus tropicalis orthologue of TRPV3 is heat sensitive.
New
Qin et al., Buffalo, United States. In J Gen Physiol, Nov 2015
For example, whereas the mammalian TRPV3 channel is activated by heat, frog TRPV3 is reportedly activated by cold.
Olmsted syndrome: clinical, molecular and therapeutic aspects.
Review
Hovnanian et al., Paris, France. In Orphanet J Rare Dis, 2014
Mutations in TRPV3 (Transient receptor potential vanilloid-3) gene have recently been identified as a cause of autosomal dominant (gain-of-function mutations) or recessive OS.
Transient Receptor Potential Cation Channel Subfamily Vanilloid Member 3 is not Involved in Plasma Membrane Stretch-induced Intracellular Calcium Signaling in Merkel Cells.
Tazaki et al., Tokyo, Japan. In Bull Tokyo Dent Coll, 2014
While these proteins are involved in sensing plasma membrane stretch, less is known about the functional properties of TRPV subfamily member 3 (TRPV3) during membrane stretch in MCs.
Systemic Administration of the TRPV3 Ion Channel Agonist Carvacrol Induces Hypothermia in Conscious Rodents.
Marrelli et al., Houston, United States. In Plos One, 2014
The current study explored the Transient Receptor Potential Vanilloid 3 (TRPV3) channel activation by the agonist carvacrol as a potential hypothermic strategy.
Thermally activated TRPV3 channels.
Review
Hu et al., Saint Louis, United States. In Curr Top Membr, 2013
TRPV3 is a temperature-sensitive transient receptor potential (TRP) ion channel.
Gating of thermally activated channels.
Review
Latorre et al., Valparaíso, Chile. In Curr Top Membr, 2013
The identification of molecular determinants of temperature sensitivity in TRPV1, TRPA1, and TRPV3 strongly suggest that thermal sensitivity arises from a specific protein domain.
TRPs in taste and chemesthesis.
Review
Roper, Miami, United States. In Handb Exp Pharmacol, 2013
Other TRP channels, including TRPM8, TRPV3, and TRPV4, play less prominent roles in chemesthesis and no known role in taste, per se.
TRPV3 as a therapeutic target for itch.
GeneRIF
Yoshioka et al., In J Invest Dermatol, 2012
TRPV3 is a therapeutic target for itch
Exome sequencing reveals mutations in TRPV3 as a cause of Olmsted syndrome.
GeneRIF
Yang et al., Beijing, China. In Am J Hum Genet, 2012
Nucleotide sequencing of five additional affected individuals also revealed missense mutations in TRPV3.
SNP variants within the vanilloid TRPV1 and TRPV3 receptor genes are associated with migraine in the Spanish population.
GeneRIF
Macaya et al., Barcelona, Spain. In Am J Med Genet B Neuropsychiatr Genet, 2012
Nominal association was confirmed for TRPV3 rs7217270 in migraine with aura and TRPV1 rs222741 in the overall migraine group.
Hysteresis of gating underlines sensitization of TRPV3 channels.
GeneRIF
Qin et al., Buffalo, United States. In J Gen Physiol, 2011
It was concluded that the sensitization of TRPV3 is intrinsic to the channel itself and occurs as a result of hysteresis of channel gating.
Evolution of vertebrate transient receptor potential vanilloid 3 channels: opposite temperature sensitivity between mammals and western clawed frogs.
GeneRIF
Tominaga et al., Okazaki, Japan. In Plos Genet, 2011
TRPV3 channel is expressed in skin, its likely role is to detect noxious cold temperatures.
TRP channel regulates EGFR signaling in hair morphogenesis and skin barrier formation.
Impact
Xu et al., Ann Arbor, United States. In Cell, 2010
Unexpectedly, we found that mice lacking the Trpv3 gene also exhibit wavy hair coat and curly whiskers.
Preventing a Perm with TRPV3.
Impact
Montell, Baltimore, United States. In Cell, 2010
Cheng et al. (2010) now demonstrate that the calcium-permeable channel TRPV3 is required for these EGFR-dependent functions.
Impaired thermosensation in mice lacking TRPV3, a heat and camphor sensor in the skin.
Impact
Patapoutian et al., Los Angeles, United States. In Science, 2005
TRPV3 is activated by heat (>33 degrees C) and, unlike most thermoTRPs, is expressed in mouse keratinocytes.
TRPV3 is a calcium-permeable temperature-sensitive cation channel.
Impact
GeneRIF
Clapham et al., Boston, United States. In Nature, 2002
member of the vanilloid channel family that is expressed in skin, tongue, dorsal root ganglion, trigeminal ganglion, spinal cord and brain; a calcium-permeable temperature-sensitive cation channel
TRPV3 is a temperature-sensitive vanilloid receptor-like protein.
Impact
GeneRIF
Davis et al., Harlow, United Kingdom. In Nature, 2002
temperature-sensitive (but capsaicin-insensitive) vanilloid receptor-like protein; may represent an additional vanilloid receptor subunit involved in the formation of heteromeric vanilloid receptor channels
Role of Transient Receptor Potential Channels in Acute and Chronic Itch
Review
Bautista et al., Boca Raton, United States. In Unknown Journal, 0001
Here, we discuss the role of four TRP channels that have been proposed to play a role in itch transduction: TRPV1, TRPA1, TRPM8, and TRPV3.
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