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Transient receptor potential cation channel, subfamily V, member 2

TRPV2, VRL-1
ion channel that may be activated by high temperature; may transduce high threshold heat responses in sensory ganglia [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: TRPV1, TRPV4, TRPV3, TRPM8, CAN
Papers using TRPV2 antibodies
Physiological roles of TRPV2 expressed in the olfactory axon
Supplier
Hirakawa Katsuhiro et al., In Acta Oto-Laryngologica, 2006
... polyclonal antibody to TRPV1 (Transgenic Inc., Kumamoto, Japan) (diluted 0.1 mg/ml), rabbit polyclonal antibody to TRPV2 (abcam, Tokyo, Japan) (diluted 1:1000), ...
Regulation of Calcium-Permeable TRPV2 Channel by Insulin in Pancreatic β-Cells
Supplier
Kojima Itaru et al., In Diabetes, 2004
... Anti-Myc Tag (clone 9E10) monoclonal IgG was obtained from Upstate (Lake Placid, NY) and anti-TRPV2 antibody was from Biomol (Plymouth Meeting, PA) ...
Papers on TRPV2
Cryo-electron microscopy structure of the TRPV2 ion channel.
New
Lee et al., Durham, United States. In Nat Struct Mol Biol, Feb 2016
TRPV2, a member of the TRPV family, is regulated by temperature, by ligands, such as probenecid and cannabinoids, and by lipids.
Nerve Growth Factor Regulates Transient Receptor Potential Vanilloid 2 via Extracellular Signal-Regulated Kinase Signaling To Enhance Neurite Outgrowth in Developing Neurons.
New
Moiseenkova-Bell et al., Cleveland, United States. In Mol Cell Biol, Jan 2016
Here we report that transient receptor potential vanilloid 2 (TRPV2) is an intracellular Ca(2+)-permeable TRPV channel upregulated by NGF via the mitogen-activated protein kinase (MAPK) signaling pathway to augment neurite outgrowth.
Novel role of TRPV2 in promoting the cytotoxicity of H2O2-mediated oxidative stress in Human hepatoma cells.
New
Li et al., Guangzhou, China. In Free Radic Biol Med, Dec 2015
Herein, we found that H2O2-mediated oxidative stress increases TRPV2 expression in human hepatoma (HepG2 and Huh-7) cells.
The involvement of medial septum 5-HT1 and 5-HT2 receptors on ACPA-induced memory consolidation deficit: Possible role of TRPC3, TRPC6 and TRPV2.
New
Zarrindast et al., Tehrān, Iran. In J Psychopharmacol, Nov 2015
Using SKF-96365 (inhibitor of transient receptor potential TRPC3/6 and TRPV2 channels) demonstrated that TRPC3, TRPC3 and TRPV2 channels have a significant role, according to our results.
Thermosensitive transient receptor potential (TRP) channel agonists and their role in mechanical, thermal and nociceptive sensations as assessed using animal models.
New
Carstens et al., Baltimore, United States. In Chemosens Percept, Aug 2015
Additional roles of other thermosensitive TRP channels (TRPM8 TRPV1, TRPV2, TRPV4, TRPM3, TRPM8, TRPA1, TRPC5) in touch, temperature and pain are reviewed.
Temperature-sensitive transient receptor potential channels in corneal tissue layers and cells.
Review
Reinach et al., Berlin, Germany. In Ophthalmic Res, 2013
Other thermo-TRP family members identified in these tissues are TRPV2, 3 and 4. Finally, there is the TRP ankyrin type 1 (TRPA1) cold receptor.
Trafficking of ThermoTRP Channels.
Review
Ferrer-Montiel et al., Alacant, Spain. In Membranes (basel), 2013
This review will focus on the recent advances trafficking of the thermoTRP channels, TRPV1, TRPV2, TRPV4, TRPM3, TRPM8 and TRPA1, into/from the plasma membrane.
Advances in transient receptor potential vanilloid-2 channel expression and function in tumor growth and progression.
Review
Santoni et al., Macao. In Curr Protein Pept Sci, 2013
Aim of this review is to study the role of the TRPV2 channel, a member of the TRPV subfamily of TRP channels, in tumor progression.
TRPV2.
Review
Nagasawa et al., Maebashi, Japan. In Handb Exp Pharmacol, 2013
Transient receptor potential vanilloid type 2, TRPV2, is a calcium-permeable cation channel belonging to the TRPV channel family.
Neuronal involvement in muscular atrophy.
Review
Sáez et al., Santiago, Chile. In Front Cell Neurosci, 2013
Recently, de novo expression of hemichannels (HCs) formed by connexins (Cxs) and other none selective channels, including P2X7 receptors (P2X7Rs), and transient receptor potential, sub-family V, member 2 (TRPV2) channels was demonstrated in denervated fast skeletal muscles.
Expression and distribution of TRPV2 in rat brain.
GeneRIF
Cunningham et al., Fort Worth, United States. In Exp Neurol, 2012
TRPV2 may play an important role in several central nervous system networks that regulate body fluid homeostasis, autonomic function, and metabolism.
Antiaging gene Klotho enhances glucose-induced insulin secretion by up-regulating plasma membrane levels of TRPV2 in MIN6 β-cells.
GeneRIF
Sun et al., Oklahoma City, United States. In Endocrinology, 2012
Klotho enhances glucose-induced insulin secretion by up-regulating plasma membrane levels of TRPV2 in MIN6 beta-cells
Calcium regulation by thermo- and osmosensing transient receptor potential vanilloid channels (TRPVs) in human conjunctival epithelial cells.
GeneRIF
Pleyer et al., Berlin, Germany. In Histochem Cell Biol, 2012
Cultivated HCjE cells and human conjunctiva express TRPV2, mRNA.
Region-specific changes in transient receptor potential vanilloid channel expression in the vasopressin magnocellular system in hepatic cirrhosis-induced hyponatraemia.
GeneRIF
Cunningham et al., Fort Worth, United States. In J Neuroendocrinol, 2012
data suggest that regionally specific changes in TRPV expression in the magnocellular neurosecretory cell AVP neurones could alter their osmosensing ability.
Translocation of calcium-permeable TRPV2 channel to the podosome: Its role in the regulation of podosome assembly.
GeneRIF
Kojima et al., Maebashi, Japan. In Cell Calcium, 2012
TRPV2 is localized abundantly in the podosome and increases [Ca(2+)](pm) by the podosome.
Sensor Mechanism and Afferent Signal Transduction of the Urinary Bladder: Special Focus on transient receptor potential Ion Channels.
Araki et al., Shenyang, China. In Low Urin Tract Symptoms, 2010
TRPV1, TRPV2, TRPV4, TRPM8, and TRPA1 have been described in different parts of the urogenital tract.
TRPV2 has a pivotal role in macrophage particle binding and phagocytosis.
Impact
GeneRIF
Caterina et al., Baltimore, United States. In Nat Immunol, 2010
TRPV2-deficient mice show accelerated mortality and greater organ bacterial load when challenged ti Listeri monocytogenes
TRPV3 is a calcium-permeable temperature-sensitive cation channel.
Impact
Clapham et al., Boston, United States. In Nature, 2002
1)), noxious heat (>52 degrees C; TRPV2 (ref.
Identification of a cold receptor reveals a general role for TRP channels in thermosensation.
Impact
Julius et al., San Francisco, United States. In Nature, 2002
These findings, together with our previous identification of the heat-sensitive channels VR1 and VRL-1, demonstrate that TRP channels detect temperatures over a wide range and are the principal sensors of thermal stimuli in the mammalian peripheral nervous system.
A capsaicin-receptor homologue with a high threshold for noxious heat.
Impact
Julius et al., San Francisco, United States. In Nature, 1999
Here we identify a structurally related receptor, VRL-1, that does not respond to capsaicin, acid or moderate heat.
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