TRP channel functions in the gastrointestinal tract.
Baltimore, United States. In Semin Immunopathol, Nov 2015
In this review, we focus on the expressions and functions of TRPV1, TRPA1, and TRPM8 in primary extrinsic afferent nerves innervated in the esophagus, stomach, intestine, and colon and briefly discuss their potential roles in relevant GI disorders.
New therapeutic approaches for the prevention and treatment of migraine.
Essen, Germany. In Lancet Neurol, Oct 2015
Other approaches targeting the transient receptor potential vanilloid (TRPV1) receptor, glutamate, GABAA receptors, or a combination of 5-HT1B/1D receptors and neuronal nitric oxide synthesis have been investigated but have not been successful in clinical trials thus far.
Wireless magnetothermal deep brain stimulation.
Cambridge, United States. In Science, Apr 2015
Here, we demonstrate minimally invasive and remote neural excitation through the activation of the heat-sensitive capsaicin receptor TRPV1 by magnetic nanoparticles.
GABA blocks pathological but not acute TRPV1 pain signals.
Heidelberg, Germany. In Cell, Mar 2015
Sensitization of the capsaicin receptor TRPV1 is central to the initiation of pathological forms of pain, and multiple signaling cascades are known to enhance TRPV1 activity under inflammatory conditions.