gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Transient receptor potential cation channel, subfamily V, member 1

TRPV1, VR1, capsaicin receptor
Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. Four transcript variants encoding the same protein, but with different 5' UTR sequence, have been described for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, TRPA1, V1a, ACID, HAD
Papers using TRPV1 antibodies
Physiological roles of TRPV2 expressed in the olfactory axon
Supplier
Hirakawa Katsuhiro et al., In Acta Oto-Laryngologica, 2006
... After pretreatment with blocking serum, the specimens were incubated with a rabbit polyclonal antibody to TRPV1 (Transgenic Inc., Kumamoto, Japan) (diluted ...
Airway reflexes, autonomic function, and cardiovascular responses.
Supplier
Farraj Aimen K. et al., In Environmental Health Perspectives, 2000
... Louis, MO) and the specific TRPV1 antagonist SB366791 (Tocris, Ellisville, MO) were dissolved ...
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.
Supplier
Wang Haibin, In PLoS ONE, 1975
... TRPV1 antibodies were purchased from Santa Cruz Biotechnology (peptide fragment: (C)EDAEVFKDSMVPGEK corresponding ...
Papers on TRPV1
Direct action of capsaicin in brown adipogenesis and activation of brown adipocytes.
New
Funaba et al., Kyoto, Japan. In Cell Biochem Funct, Feb 2016
We herein demonstrated that Trpv1, a capsaicin receptor, is expressed in brown adipose tissue, and that its expression level is increased during the differentiation of HB2 brown preadipocytes.
Cryo-electron microscopy structure of the TRPV2 ion channel.
New
Lee et al., Durham, United States. In Nat Struct Mol Biol, Feb 2016
In the TRPV2 structure, the transmembrane segment 6 (S6), which is involved in gate opening, adopts a conformation different from the one observed in TRPV1.
Persistent alterations in colonic afferent innervation in a rat model of postinfectious gut dysfunction: Role for changes in peripheral neurotrophic factors.
New
Vergara et al., Barcelona, Spain. In Neurogastroenterol Motil, Feb 2016
Stimulation with intracolonic capsaicin induced a down-regulation of TRPV1 levels in TL and LS DRGs, an effect enhanced in LS DRGs of infected animals, regardless the postinfection time considered.
ARA 290 relieves pathophysiological pain by targeting TRPV1 channel: integration between immune system and nociception.
New
Zhang et al., Jinan, China. In Peptides, Feb 2016
Using calcium imaging, cell culture and behavioral tests, we demonstrated that ARA 290 was able to specifically inhibit TRPV1 channel activity, and relieve the mechanical hypersensitivity induced by capsaicin.
The endocannabinoid system in the human granulosa cell line KGN.
New
Dehghani et al., Halle, Germany. In Mol Cell Endocrinol, Feb 2016
CB1, CB2, DAGL, FAAH, GPR55, MAGL, NAPE-PLD and TRPV1 were expressed without FSH-dependent effects.
TRP channel mediated neuronal activation and ablation in freely behaving zebrafish.
New
Impact
Prober et al., Pasadena, United States. In Nat Methods, Jan 2016
We exploit these properties by using transient receptor potential (TRP) channels to activate or ablate specific neuronal populations using the chemical and thermal agonists of heterologously expressed TRPV1, TRPM8 and TRPA1.
Receptome: Interactions between three pain-related receptors or the "Triumvirate" of cannabinoid, opioid and TRPV1 receptors.
Review
New
Wollemann et al., Szeged, Hungary. In Pharmacol Res, Dec 2015
A growing amount of data demonstrates the interactions between cannabinoid, opioid and the transient receptor potential (TRP) vanilloid type 1 (TRPV1) receptors.
Roles of Proton-Sensing Receptors in the Transition from Acute to Chronic Pain.
Review
New
Chen et al., Taiwan. In J Dent Res, Dec 2015
Acid-sensing ion channel 3 (ASIC3) and transient receptor potential/vanilloid receptor subtype 1 (TRPV1) are 2 major acid sensors involved in the proton-induced hyperalgesic priming.
TRP channel functions in the gastrointestinal tract.
Review
New
Yu et al., Baltimore, United States. In Semin Immunopathol, Nov 2015
In this review, we focus on the expressions and functions of TRPV1, TRPA1, and TRPM8 in primary extrinsic afferent nerves innervated in the esophagus, stomach, intestine, and colon and briefly discuss their potential roles in relevant GI disorders.
New therapeutic approaches for the prevention and treatment of migraine.
Review
New
Impact
Holle et al., Essen, Germany. In Lancet Neurol, Oct 2015
Other approaches targeting the transient receptor potential vanilloid (TRPV1) receptor, glutamate, GABAA receptors, or a combination of 5-HT1B/1D receptors and neuronal nitric oxide synthesis have been investigated but have not been successful in clinical trials thus far.
Role of oxidative stress & transient receptor potential in chronic obstructive pulmonary disease.
Review
New
Maudar et al., Bhopāl, India. In Indian J Med Res, Sep 2015
Nociceptor neurons include transient receptor potential (TRP) ion channels, especially the vanilloid and ankyrin subfamilies, TRPV1/A1 which can be activated by noxious chemical challenges in models of airways disease.
Wireless magnetothermal deep brain stimulation.
New
Impact
Anikeeva et al., Cambridge, United States. In Science, Apr 2015
Here, we demonstrate minimally invasive and remote neural excitation through the activation of the heat-sensitive capsaicin receptor TRPV1 by magnetic nanoparticles.
GABA blocks pathological but not acute TRPV1 pain signals.
New
Impact
Siemens et al., Heidelberg, Germany. In Cell, Mar 2015
Sensitization of the capsaicin receptor TRPV1 is central to the initiation of pathological forms of pain, and multiple signaling cascades are known to enhance TRPV1 activity under inflammatory conditions.
Remote regulation of glucose homeostasis in mice using genetically encoded nanoparticles.
Impact
Friedman et al., New York City, United States. In Nat Med, 2015
The ferritin nanoparticles associate with a camelid anti-GFP-transient receptor potential vanilloid 1 fusion protein, αGFP-TRPV1, and can transduce noninvasive RF or magnetic fields into channel activation, also showing that TRPV1 can transduce a mechanical stimulus.
Capsaicin and Related Food Ingredients Reducing Body Fat Through the Activation of TRP and Brown Fat Thermogenesis.
Review
Saito, Sapporo, Japan. In Adv Food Nutr Res, 2014
Capsaicin and its analog capsinoids, representative agonists of TRPV1, mimic the effects of cold to decrease body fatness through the activation and recruitment of BAT.
The C-type natriuretic peptide induces thermal hyperalgesia through a noncanonical Gβγ-dependent modulation of TRPV1 channel.
GeneRIF
Mohapatra et al., Iowa City, United States. In J Neurosci, 2012
Potentiation of TRPV1 as a novel signaling cascade recruited by C-type natriuretic peptide CNP in dorsal root ganglia neurons leads to enhanced nociceptor excitability and thermal hypersensitivity and increases neuronal firing frequency.
Activation of NMDA receptors leads to phosphorylation of TRPV1 S800 by protein kinase C and A-Kinase anchoring protein 150 in rat trigeminal ganglia.
GeneRIF
Ro et al., Baltimore, United States. In Biochem Biophys Res Commun, 2012
NMDA receptor, AKAP150, and TRPV1 forms a signaling complex that underlies the sensitization of trigeminal nociceptors by modulating phosphorylation of specific TRPV1 residues.
[Etiology of nonspecific chronic cough in children and relationship between TRPV1 gene polymorphisms and nonspecific chronic cough].
GeneRIF
Liu et al., Chongqing, China. In Zhongguo Dang Dai Er Ke Za Zhi, 2012
TRPV1 gene polymorphisms at positions rs222748 and rs8065080 may be unrelated to nonspecific chronic cough in children.
Association between single nucleotide polymorphisms of the transient receptor potential vanilloid 1 (TRPV-1) gene and patients with irritable bowel syndrome in Korean populations.
GeneRIF
Joo et al., Kwangju, South Korea. In Acta Gastroenterol Belg, 2012
Results suggest that the single nucleotide polymorphisms of the TRPV1 gene may not be associated with irritable bowel syndrome in Korean populations.
[Interaction of sea amemone Heteractis crispa Kunitz type polypeptides with pain vanilloid receptor TRPV1: in silico investigation].
GeneRIF
Kozlovskaia et al., In Bioorg Khim, 2012
Interaction of sea amemone Heteractis crispa Kunitz type polypeptides with pain vanilloid receptor TRPV1
share on facebooktweetadd +1mail to friends