The role of TRPMLs in endolysosomal trafficking and function.
Houston, United States. In Cell Calcium, Jul 2015
Whereas loss-of-function mutations in human TRPML1 were first identified as being causative for the lysosomal storage disease, Mucolipidosis type IV, most mammals also express two other TRPML isoforms called TRPML2 and TRPML3.
Role of the transient receptor potential (TRP) channel gene expressions and TRP melastatin (TRPM) channel gene polymorphisms in obesity-related metabolic syndrome.
Gaziantep, Turkey. In Eur Rev Med Pharmacol Sci, Apr 2015
Although there were marked decreases in TRPC1, TRPC3, TRPM2, TRPM5, TRPV4, TRPV5, TRPV6, MCOLN2 (TRPML2), and MCOLN3 (TRPML3) gene expressions, an augmentation was noted in TRPC6 gene expression.
TRPs in hearing.
Göttingen, Germany. In Handb Exp Pharmacol, 2013
In vertebrates, TRPs are unlikely to form auditory transduction channels, yet most TRPs are expressed in inner ear tissues, and mutations in TRPN1, TRPVA1, TRPML3, TRPV4, and TRPC3/TRPC6 have been implicated in inner ear function.
München, Germany. In Handb Exp Pharmacol, 2013
TRPML3 belongs to the MCOLN (TRPML) subfamily of transient receptor potential (TRP) channels comprising three genes in mammals.
TRPML2 and mucolipin evolution.
Chicago, United States. In Handb Exp Pharmacol, 2013
This contrasts with the ubiquitous expression of TRPML1 and the limited but diverse expression of TRPML3 and clearly suggests a specialized role for TRPML2 in immunity.