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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Transient receptor potential cation channel, subfamily M, member 8

TRPM8
excitatory ion channel; may be involved in transducing cold stimuli [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: TRPV1, TRPA1, melastatin, CAN, TRPV4
Papers on TRPM8
TRPing on the pore phenomenon: what do we know about transient receptor potential ion channel-related pore dilation up to now?
New
Faria et al., Rio de Janeiro, Brazil. In J Bioenerg Biomembr, Feb 2016
The TRPA1, TRPM8, and TRPV1-4 subtypes have been shown to promote large-molecular-weight solute uptake, including impermeable fluorescent dyes, QX-314 hydrophilic lidocaine derivative, gabapentin, and antineoplastic drugs.
Data-driven Analysis of TRP Channels in Cancer: Linking Variation in Gene Expression to Clinical Significance.
New
Shin et al., Seoul, South Korea. In Cancer Genomics Proteomics, Feb 2016
TRPM8 was identified as a new molecular marker for lung cancer diagnosis and TRPP1 for kidney cancer prognosis.
Enhancement by citral of glutamatergic spontaneous excitatory transmission in adult rat substantia gelatinosa neurons.
New
Kumamoto et al., Saga, Japan. In Neuroreport, Jan 2016
Citral activates in heterologous cells transient receptor potential vanilloid-1, ankyrin-1, and melastatin-8 (TRPV1, TRPA1, and TRPM8, respectively) channels, the activation of which in the spinal lamina II [substantia gelatinosa (SG)] increases the spontaneous release of L-glutamate from nerve terminals.
TRP channel mediated neuronal activation and ablation in freely behaving zebrafish.
New
Impact
Prober et al., Pasadena, United States. In Nat Methods, Jan 2016
We exploit these properties by using transient receptor potential (TRP) channels to activate or ablate specific neuronal populations using the chemical and thermal agonists of heterologously expressed TRPV1, TRPM8 and TRPA1.
3-Iodothyronamine increases transient receptor potential melastatin channel 8 (TRPM8) activity in immortalized human corneal epithelial cells.
New
Mergler et al., Berlin, Germany. In Cell Signal, Jan 2016
3T1AM also directly activates cold-sensitive transient receptor potential melastatin 8 (TRPM8) channels in human conjunctival epithelial cells (HCjEC) at constant temperature as well as reducing rises in IL-6 release induced by transient receptor potential vanilloid 1 (TRPV1) activation by capsaicin (CAP).
TRP channel functions in the gastrointestinal tract.
Review
New
Yu et al., Baltimore, United States. In Semin Immunopathol, Nov 2015
In this review, we focus on the expressions and functions of TRPV1, TRPA1, and TRPM8 in primary extrinsic afferent nerves innervated in the esophagus, stomach, intestine, and colon and briefly discuss their potential roles in relevant GI disorders.
TRPs and pain.
Review
New
Dai, Kōbe, Japan. In Semin Immunopathol, Oct 2015
Several member of this family, at least six channels from three TRP family subtypes (TRPV1-4, TRPM8, and TRPA1), are expressed in nociceptors, where they act as transducers for signals from thermal, chemical, and mechanical stimuli and play crucial roles in the generation and development of pathological pain perception.
TRP Channels in Respiratory Pathophysiology: the Role of Oxidative, Chemical Irritant and Temperature Stimuli.
Review
Zholos, Kiev, Ukraine. In Curr Neuropharmacol, 2014
Several of these channels, such as TRPM2, TRPM8, TRPA1 and TRPV1, are discussed in much detail to show that they perform diverse, and often overlapping or contributory, roles in airway hyperreactivity, inflammation, asthma, chronic obstructive pulmonary disease and other respiratory disorders.
Roles of TRPM8 Ion Channels in Cancer: Proliferation, Survival, and Invasion.
Review
Yee, State College, United States. In Cancers (basel), 2014
The goal of this article is to provide a critical review of the transient receptor potential melastatin-subfamily member 8 (TRPM8) in cancers, with an emphasis on its roles in cellular proliferation, survival, and invasion.
Cooling the Skin: Understanding a Specific Cutaneous Thermosensation.
Review
Kim et al., Kwangju, South Korea. In J Lifestyle Med, 2013
We successively treated her using a topical formulation of TRPM8 agonist which produces a cooling sensation.
Direct inhibition of the cold-activated TRPM8 ion channel by Gαq.
Impact
McNaughton et al., Cambridge, United Kingdom. In Nat Cell Biol, 2012
Activation of the TRPM8 ion channel in sensory nerve endings produces a sensation of pleasant coolness.
Genome-wide association analysis identifies susceptibility loci for migraine without aura.
Impact
International Headache Genetics Consortium et al., München, Germany. In Nat Genet, 2012
We also replicated associations at two previously reported migraine loci in or near TRPM8 and LRP1.
The TRPM8 ion channel comprises direct Gq protein-activating capacity.
GeneRIF
Wetzel et al., Bochum, Germany. In Pflugers Arch, 2012
The TRPM8 ion channel comprises direct Gq protein-activating capacity.
N-glycosylation of TRPM8 ion channels modulates temperature sensitivity of cold thermoreceptor neurons.
GeneRIF
Viana et al., Alacant, Spain. In J Biol Chem, 2012
results indicate that post-translational modification of TRPM8 is an important mechanism modulating cold thermoreceptor function
Blockade of TRPM8 activity reduces the invasion potential of oral squamous carcinoma cell lines.
GeneRIF
Yamazaki et al., Fukuoka, Japan. In Int J Oncol, 2012
Blockade of TRPM8 activity reduces cell migration and the invasion potential of tongue squamous carcinoma cell lines.
Activation of the cold-sensing TRPM8 channel triggers UCP1-dependent thermogenesis and prevents obesity.
GeneRIF
Zhu et al., Chongqing, China. In J Mol Cell Biol, 2012
Activation of the cold-sensing TRPM8 channel triggers UCP1-dependent thermogenesis and prevents obesity.
Cold Stress and Urinary Frequency.
Nishizawa et al., Matsumoto, Japan. In Low Urin Tract Symptoms, 2012
In 2002, it was reported that a nonselective cation channel, TRPM8, could be activated by both menthol and thermal stimuli (8-28 °C).
[Effects of transient receptor potential melastatin 8 cation channels on inflammatory reaction induced by cold temperatures in human airway epithelial cells].
GeneRIF
Zhou et al., Chongqing, China. In Zhonghua Jie He He Hu Xi Za Zhi, 2011
Cold temperature may induce Ca(2+) influx and up-regulate IL-6, IL-8, and TNF-alpha expression in 16HBE cells by activating TRPM8 ion channels.
Genome-wide association study reveals three susceptibility loci for common migraine in the general population.
Impact
Kurth et al., Boston, United States. In Nat Genet, 2011
TRPM8) and rs11172113 (12q13.3,
Ocular surface wetness is regulated by TRPM8-dependent cold thermoreceptors of the cornea.
Impact
GeneRIF
Belmonte et al., San Juan de Alicante, Spain. In Nat Med, 2010
Ocular surface wetness is regulated by TRPM8-dependent cold thermoreceptors of the cornea.
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