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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Transient receptor potential cation channel, subfamily M, member 7

The protein encoded by this gene is both an ion channel and a serine/threonine protein kinase. The kinase activity is essential for the ion channel function, which serves to increase intracellular calcium levels and to help regulate magnesium ion homeostasis. Defects in this gene are a cause of amyotrophic lateral sclerosis-parkinsonism/dementia complex of Guam.[provided by RefSeq, May 2010] (from NCBI)
Top mentioned proteins: melastatin, TRPM6, V1a, CAN, Trp7
Papers on TRPM7
Functional characterization of TRPM7 in nasopharyngeal carcinoma and its knockdown effects on tumorigenesis.
Wang et al., Zhuhai, China. In Tumour Biol, Feb 2016
UNASSIGNED: The aim of this study was to evaluate the association of functional expression of TRPM7 with nasopharyngeal carcinoma (NPC) growth.
Stress hormone potentiates Zn(2+)-induced neurotoxicity via TRPM7 channel in dopaminergic neuron.
Chung et al., Suwŏn, South Korea. In Biochem Biophys Res Commun, Feb 2016
Recently, it was reported that the zinc permeable transient receptor potential melastatin 7 (TRPM7) channel may represent a novel target for neurological disorders where zinc toxicity plays an important role.
Mesendogen, a novel inhibitor of TRPM6, promotes mesoderm and definitive endoderm differentiation of human embryonic stem cells through alteration of magnesium homeostasis.
Feng et al., Urbana, United States. In Heliyon, Jan 2016
UNASSIGNED: The homo- and hetero-tetrameric channel complexes formed by transient receptor potential cation channel, subfamily M, member 6 (TRPM6) and 7 (TRPM7) (collectively referred to as TRPM6/TRPM7 channels in this study) are the major regulators of cellular magnesium uptake, yet the exact roles of TRPM6/TRPM7 channels and cellular magnesium homeostasis during development are poorly understood.
Plasma membrane calcium channels in cancer: Alterations and consequences for cell proliferation and migration.
Constantin et al., Poitiers, France. In Biochim Biophys Acta, Oct 2015
TRPV can sense changes in the physical and chemical environment of cancer cells and TRPM7 are stretch activated and sensitive to cholesterol.
Non-NMDAR neuronal Ca(2+)-permeable channels in delayed neuronal death and as potential therapeutic targets for ischemic brain damage.
Jiang et al., Xinxiang, China. In Expert Opin Ther Targets, Jul 2015
AREAS COVERED: In this review, the authors discuss the GluA2-lacking AMPARs, acid-sensing ion channel 1a, melastatin-related transient receptor potential 2 (TRPM2), TRPM7 and store-operated Ca(2+) channels expressed in ischemia-vulnerable neurons, and focus on the studies using in vitro and in vivo models of transient ischemia that supports a significant role for these channels in inducing increases in the [Ca(2+)]c and/or [Zn(2+)]c and delayed neuronal death, and their potential as therapeutic targets.
Novel insights into TRPM7 function in fibrotic diseases: a potential therapeutic target.
Li et al., Hefei, China. In J Cell Physiol, Jun 2015
Accumulating evidence has demonstrated that TRPM7, a member of TRP channels superfamily, participates in the development and pathogenesis of fibrotic diseases, such as hepatic, pulmonary and cardiac fibrosis.
TRPM channels and magnesium in early embryonic development.
Runnels et al., United States. In Int J Dev Biol, 2014
Recent studies have continued to add to the growing number of Mg (2+)transporters and ion channels involved in Mg (2+)homeostasis, including TRPM6 and TRPM7, members of the transient receptor potential (TRP) ion channel family.
Hepatocystin is Essential for TRPM7 Function During Early Embryogenesis.
Runnels et al., United States. In Sci Rep, 2014
Here, we investigated the function of hepatocystin during Xenopus laevis embryogenesis and identified hepatocystin as a binding partner of the TRPM7 ion channel, whose function is required for vertebrate gastrulation.
The Different Roles of The Channel-Kinases TRPM6 and TRPM7.
Colenso et al., Valdivia, Chile. In Curr Med Chem, 2014
Melastatin-related Transient Receptor Potential 6 and 7 (TRPM6 and TRPM7) are cation channels with the almost unique trait of each possessing a kinase domain in its C terminus.
The TRPM7 chanzyme is cleaved to release a chromatin-modifying kinase.
Clapham et al., Boston, United States. In Cell, 2014
TRPM7 is a ubiquitous ion channel and kinase, a unique "chanzyme," required for proper early embryonic development.
Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis.
Liu et al., Bethesda, United States. In Nat Cell Biol, 2014
Furthermore, we identified that TRPM7 (transient receptor potential melastatin related 7) is a MLKL downstream target for the mediation of Ca(2+) influx and TNF-induced necroptosis.
Natural and Synthetic Modulators of the TRPM7 Channel.
Gudermann et al., München, Germany. In Cells, 2013
Transient receptor potential cation channel subfamily M member 7 (TRPM7) is a bi-functional protein comprising a TRP ion channel segment linked to an α-type protein kinase domain.
Magnesium and its transporters in cancer: a novel paradigm in tumour development.
Trapani et al., Roma, Italy. In Clin Sci (lond), 2012
Alteration in the expression and/or activity of magnesium channels is a frequent finding in cancer cells.
Evidence for functional expression of TRPM7 channels in human atrial myocytes.
Li et al., Hong Kong, Hong Kong. In Basic Res Cardiol, 2012
TRPM7 channels are present in human atrial myocytes, and the channel expression is upregulated in the atria with atrial fibrillation.
TRPM7: a unique channel involved in magnesium homeostasis.
Gudermann et al., Australia. In Int J Biochem Cell Biol, 2012
Studies indicate functional roles of TRPM7 in neurological and cardiovascular disease.
Cleavage of TRPM7 releases the kinase domain from the ion channel and regulates its participation in Fas-induced apoptosis.
Clapham et al., Boston, United States. In Dev Cell, 2012
It was shown that TRPM7 regulates endocytic compartmentalization of the Fas receptor after receptor stimulation, an important process for apoptotic signaling.
Expression of transient receptor potential melastatin 7 up-regulated in the early stage of renal ischemia-reperfusion.
Xiang et al., Wuhan, China. In Transplant Proc, 2012
The expressions of TRPM7 mRNA and protein levels was up-regulated at 24 hours after renal ischemia.
Calcium flickers steer cell migration.
Cheng et al., Beijing, China. In Nature, 2009
Calcium flicker activity is dually coupled to membrane tension (by means of TRPM7, a stretch-activated Ca(2+)-permeant channel of the transient receptor potential superfamily) and chemoattractant signal transduction (by means of type 2 inositol-1,4,5-trisphosphate receptors).
Deletion of Trpm7 disrupts embryonic development and thymopoiesis without altering Mg2+ homeostasis.
Clapham et al., Boston, United States. In Science, 2008
deletion of Trpm7 showed it is essential for embryo development; tissue-specific deletion of Trpm7 in T cell lineage disrupted thymopoiesis, which led to developmental block of thymocytes at the double-negative stage & depletion of thymic medullary cells
TRPM7 ion channels are required for sustained phosphoinositide 3-kinase signaling in lymphocytes.
Scharenberg et al., Seattle, United States. In Cell Metab, 2008
Lymphocytes lacking the TRPM7 (transient receptor potential cation channel, subfamily M, member 7) dual function ion channel/protein kinase exhibit a unique phenotype: they are unable to proliferate in regular media, but proliferate normally in media supplemented with 10-15 mM extracellular Mg(2+).
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