Non-NMDAR neuronal Ca(2+)-permeable channels in delayed neuronal death and as potential therapeutic targets for ischemic brain damage.
Xinxiang, China. In Expert Opin Ther Targets, Jul 2015
AREAS COVERED: In this review, the authors discuss the GluA2-lacking AMPARs, acid-sensing ion channel 1a, melastatin-related transient receptor potential 2 (TRPM2), TRPM7 and store-operated Ca(2+) channels expressed in ischemia-vulnerable neurons, and focus on the studies using in vitro and in vivo models of transient ischemia that supports a significant role for these channels in inducing increases in the [Ca(2+)]c and/or [Zn(2+)]c and delayed neuronal death, and their potential as therapeutic targets.
TRPM channels and magnesium in early embryonic development.
United States. In Int J Dev Biol, 2014
Recent studies have continued to add to the growing number of Mg (2+)transporters and ion channels involved in Mg (2+)homeostasis, including TRPM6 and TRPM7, members of the transient receptor potential (TRP) ion channel family.
Calcium flickers steer cell migration.
Beijing, China. In Nature, 2009
Calcium flicker activity is dually coupled to membrane tension (by means of TRPM7, a stretch-activated Ca(2+)-permeant channel of the transient receptor potential superfamily) and chemoattractant signal transduction (by means of type 2 inositol-1,4,5-trisphosphate receptors).