TRPM7 and its role in neurodegenerative diseases.
Grand Forks, United States. In Channels (austin), Oct 2015
Among the known 8 TRPM channels only TRPM6 and TRPM7 channels are highly permeable to both Ca(2+) and Mg(2+); however here we will only focus on TRPM7 as unlike TRPM6, TRPM7 channels are abundantly expressed in neuronal cells.
The art of magnesium transport.
Nijmegen, Netherlands. In Magnes Res, Sep 2015
TRPM6 mediates apical Mg(2+) entry into the DCT cell and is highly regulated by EGF, insulin and pH.
Magnesium in man: implications for health and disease.
Nijmegen, Netherlands. In Physiol Rev, 2015
Over the last decade, several hereditary forms of hypomagnesemia have been deciphered, including mutations in transient receptor potential melastatin type 6 (TRPM6), claudin 16, and cyclin M2 (CNNM2).
Distal convoluted tubule.
Portland, United States. In Compr Physiol, 2015
These cells also play a key role in magnesium reabsorption, which occurs predominantly, via a transient receptor potential channel (TRPM6).
TRPM channels and magnesium in early embryonic development.
United States. In Int J Dev Biol, 2014
Mutations in TRPM6, including amino acid substitutions that prevent its heterooligomerization with TRPM7, occur in the rare autosomal-recessive disease hypomagnesemia with secondary hypocalcemia (HSH).