Distal convoluted tubule.
Portland, United States. In Compr Physiol, 2015
These cells also play a key role in magnesium reabsorption, which occurs predominantly, via a transient receptor potential channel (TRPM6).
Magnesium in man: implications for health and disease.
Nijmegen, Netherlands. In Physiol Rev, 2015
Over the last decade, several hereditary forms of hypomagnesemia have been deciphered, including mutations in transient receptor potential melastatin type 6 (TRPM6), claudin 16, and cyclin M2 (CNNM2).
TRPM channels and magnesium in early embryonic development.
United States. In Int J Dev Biol, 2014
Mutations in TRPM6, including amino acid substitutions that prevent its heterooligomerization with TRPM7, occur in the rare autosomal-recessive disease hypomagnesemia with secondary hypocalcemia (HSH).
Mg2+ homeostasis: the balancing act of TRPM6.
Nijmegen, Netherlands. In Curr Opin Nephrol Hypertens, 2014
This review aims to give an up-to-date overview of transient receptor potential melastatin 6 (TRPM6) regulation and its role in the maintenance of Mg homeostasis.