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Transient receptor potential cation channel, subfamily M, member 6

This gene is predominantly expressed in the kidney and colon, and encodes a protein containing an ion channel domain and a protein kinase domain. It is crucial for magnesium homeostasis, and plays an essential role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Mutations in this gene are associated with hypomagnesemia with secondary hypocalcemia. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Apr 2010] (from NCBI)
Top mentioned proteins: TRPM7, melastatin, V1a, TRPV5, CAN
Papers on TRPM6
Clinical presentation of a patient with a novel homozygous mutation in the TRPM6 gene.
Tosun et al., In J Clin Res Pediatr Endocrinol, Jan 2016
UNASSIGNED: Hereditary hypomagnesemia with secondary hypocalcemia (HSH) is a rare autosomal recessive disease caused by mutations in the Transient Receptor Potential Melastatin 6 (TRPM6) gene.
Mesendogen, a novel inhibitor of TRPM6, promotes mesoderm and definitive endoderm differentiation of human embryonic stem cells through alteration of magnesium homeostasis.
Feng et al., Urbana, United States. In Heliyon, Jan 2016
UNASSIGNED: The homo- and hetero-tetrameric channel complexes formed by transient receptor potential cation channel, subfamily M, member 6 (TRPM6) and 7 (TRPM7) (collectively referred to as TRPM6/TRPM7 channels in this study) are the major regulators of cellular magnesium uptake, yet the exact roles of TRPM6/TRPM7 channels and cellular magnesium homeostasis during development are poorly understood.
The role of calbindin-D28k on renal calcium and magnesium handling during treatment with loop or thiazide diuretics.
Lien et al., Dschang, Cameroon. In Am J Physiol Renal Physiol, Dec 2015
Urine Mg excretion was increased and TRPM6 was upregulated by both CTZ and FSM in WT and KO mice.
'Lemonade Legs': Why do Some Patients Get Profound Hypomagnesaemia on Proton-Pump Inhibitors?
Travis et al., Oxford, United Kingdom. In Intestinal Res, Jul 2015
The cellular mechanisms of magnesium homeostasis are increasingly being understood, including both passive paracellular absorption through claudins and active transcellular transporters, including the transient receptor potential channels (TRPM6) identified in the intestine and nephron.
Distal convoluted tubule.
Ellison et al., Portland, United States. In Compr Physiol, 2015
These cells also play a key role in magnesium reabsorption, which occurs predominantly, via a transient receptor potential channel (TRPM6).
Magnesium in man: implications for health and disease.
Bindels et al., Nijmegen, Netherlands. In Physiol Rev, 2015
Over the last decade, several hereditary forms of hypomagnesemia have been deciphered, including mutations in transient receptor potential melastatin type 6 (TRPM6), claudin 16, and cyclin M2 (CNNM2).
Magnesium homeostasis in colon carcinoma LoVo cells sensitive or resistant to doxorubicin.
Maier et al., Roma, Italy. In Sci Rep, 2014
Accordingly, resistant cells express lower amounts of the TRPM6 and 7, both involved in magnesium transport.
The Different Roles of The Channel-Kinases TRPM6 and TRPM7.
Colenso et al., Valdivia, Chile. In Curr Med Chem, 2014
Melastatin-related Transient Receptor Potential 6 and 7 (TRPM6 and TRPM7) are cation channels with the almost unique trait of each possessing a kinase domain in its C terminus.
TRPM channels and magnesium in early embryonic development.
Runnels et al., United States. In Int J Dev Biol, 2014
Mutations in TRPM6, including amino acid substitutions that prevent its heterooligomerization with TRPM7, occur in the rare autosomal-recessive disease hypomagnesemia with secondary hypocalcemia (HSH).
Analysis of Factors Influencing the Development of Hypomagnesemia in Patients Receiving Cetuximab Therapy for Head and Neck Cancer.
Nagayama et al., Ōsaka, Japan. In Yakugaku Zasshi, 2014
Magnesium is reabsorbed by transient receptor potential subfamily melastatin 6 (TRPM6) in the distal convoluted tubule.
Novel Alleles of gon-2, a C. elegans Ortholog of Mammalian TRPM6 and TRPM7, Obtained by Genetic Reversion Screens.
Yuen et al., München, Germany. In Plos One, 2014
The C. elegans genes, gon-2, gtl-1 and gtl-2, encode paralogous TRP cation channel proteins that are similar in sequence and function to human TRPM6 and TRPM7.
Mg, Zn and Cu Transport Proteins: A Brief Overview from Physiological and Molecular Perspectives.
Kambe et al., Kyoto, Japan. In J Nutr Sci Vitaminol (tokyo), 2014
Specifically, TRPM6 channels in Mg absorption, ZIP4 and ZnT1 transporters for Zn absorption, and CTR1 and ATP7A for Cu absorption are overviewed.
Mg2+ homeostasis: the balancing act of TRPM6.
Hoenderop et al., Nijmegen, Netherlands. In Curr Opin Nephrol Hypertens, 2014
This review aims to give an up-to-date overview of transient receptor potential melastatin 6 (TRPM6) regulation and its role in the maintenance of Mg homeostasis.
Magnesium and its transporters in cancer: a novel paradigm in tumour development.
Trapani et al., Roma, Italy. In Clin Sci (lond), 2012
Alteration in the expression and/or activity of magnesium channels is a frequent finding in cancer cells.
Loss of insulin-induced activation of TRPM6 magnesium channels results in impaired glucose tolerance during pregnancy.
Hoenderop et al., Nijmegen, Netherlands. In Proc Natl Acad Sci U S A, 2012
Loss of insulin-induced activation of TRPM6 magnesium channels results in impaired glucose tolerance during pregnancy
Clinical and molecular characterization of Turkish patients with familial hypomagnesaemia: novel mutations in TRPM6 and CLDN16 genes.
Schlingmann et al., İstanbul, Turkey. In Nephrol Dial Transplant, 2012
A novel mutation of TRPM6 gene is responsible for the development of familial hypommagnesaemia in Turkish children.
Dietary Mg2+ regulates the epithelial Mg2+ channel TRPM6 in rat mammary tissue.
Wolf et al., Roma, Italy. In Magnes Res, 2011
This work confirms and extends our previous results on TRPM6 modulation by Mg(2+) availability in mammary tissues.
Dysregulation of renal transient receptor potential melastatin 6/7 but not paracellin-1 in aldosterone-induced hypertension and kidney damage in a model of hereditary hypomagnesemia.
Touyz et al., Ottawa, Canada. In J Hypertens, 2011
in a model of inherited hypomagnesemia, TRPM6 and TRPM7, but not paracellin-1, are downregulated
Mutation of TRPM6 causes familial hypomagnesemia with secondary hypocalcemia.
Sheffield et al., Iowa City, United States. In Nat Genet, 2002
Individuals with TRPM6 mutations have abnormal renal magnesium excretion. Deficiency causes hypomagnesemia with secondary hypocalcemia.
Hypomagnesemia with secondary hypocalcemia is caused by mutations in TRPM6, a new member of the TRPM gene family.
Konrad et al., Marburg an der Lahn, Germany. In Nat Genet, 2002
Deficiency /mutations of TRPM6 causes hypomagnesemia with secondary hypocalcemia
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