Cholinergic chemosensory cells of the thymic medulla express the bitter receptor Tas2r131.
Gießen, Germany. In Int Immunopharmacol, Nov 2015
We recently described a distinct subset of medullary epithelial cells in the murine thymus which express the acetylcholine-synthesizing enzyme choline acetyltransferase (ChAT) and components of the canonical taste transduction cascade, i.e. transient receptor potential melastatin-like subtype 5 channel (TRPM5), phospholipase Cβ2, and Gα-gustducin.
TRPs in taste and chemesthesis.
Miami, United States. In Handb Exp Pharmacol, 2013
Specifically, TRPM5 acts downstream of taste receptors in the taste transduction pathway.
Los Angeles, United States. In Handb Exp Pharmacol, 2013
TRPM5 is a Ca(2+)-activated cation channel that mediates signaling in taste and other chemosensory cells.
Leuven, Belgium. In Handb Exp Pharmacol, 2013
Unlike TRPM5, its closest relative in the transient receptor potential family, TRPM4 proteins are widely expressed in the body.
TRPs in olfaction.
Homburg, Germany. In Handb Exp Pharmacol, 2013
There is mounting evidence that TRPC2 is not the only TRP channel expressed in cells of the olfactory system but that other TRP channel subtypes such as TRPC1, TRPC4, TRPC6, TRPM4, and TRPM5 could also play important functional roles in mammalian olfaction.
FXYD6, a Na,K-ATPase regulator, is expressed in type II taste cells.
Moriya, Japan. In Biosci Biotechnol Biochem, 2010
FXYD6, a Na,K-ATPase regulator, is expressed in type II taste cells. Fxyd6 is coexpressed with transient receptor potential cation channel, subfamily M, member 5 (Trpm5), a critical component of the taste signal transduction pathways.