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Transient receptor potential cation channel, subfamily C, member 5

TRPC5, trp5
This gene belongs to the transient receptor family. It encodes one of the seven mammalian TRPC (transient receptor potential channel) proteins. The encoded protein is a multi-pass membrane protein and is thought to form a receptor-activated non-selective calcium permeant cation channel. The protein is active alone or as a heteromultimeric assembly with TRPC1, TRPC3, and TRPC4. It also interacts with multiple proteins including calmodulin, CABP1, enkurin, Na(+)-H+ exchange regulatory factor (NHERF ), interferon-induced GTP-binding protein (MX1), ring finger protein 24 (RNF24), and SEC14 domain and spectrin repeat-containing protein 1 (SESTD1). [provided by RefSeq, May 2010] (from NCBI)
Top mentioned proteins: TRPC1, TRPC4, TRPC3, Trp6, CAN
Papers on TRPC5
Functional interplay between ganglioside GM1 and cross-linking galectin-1 induces axon-like neuritogenesis via integrin-based signaling and TRPC5-dependent Ca(2+) influx.
New
Ledeen et al., Newark, United States. In J Neurochem, Feb 2016
This leads to a transient increase in the intracellular Ca(2+) concentration by opening of TRPC5 channels, which belong to the signal transduction-gated cation channels.
Critical roles of Gi/o proteins and phospholipase C-δ1 in the activation of receptor-operated TRPC4 channels.
New
Zhu et al., Homburg, Germany. In Proc Natl Acad Sci U S A, Feb 2016
This mechanism is not shared with the closely related TRPC5, implicating unique roles of TRPC4 in signal integration in brain and other systems.
The contribution of TRPC1, TRPC3, TRPC5 and TRPC6 to touch and hearing.
New
Wood et al., London, United Kingdom. In Neurosci Lett, Feb 2016
Evidence is accumulating that members of the canonical subfamily of TRP channels (TRPC) are involved in touch and hearing.
Transient receptor potential channel C5 in cancer chemoresistance.
Review
New
Ma et al., Wuxi, China. In Acta Pharmacol Sin, Jan 2016
This review provides a brief short overview of mammalian TRP channels with a focus on TRPC5 and its role in cancers.
Intracellular spermine blocks TRPC4 channel via electrostatic interaction with C-terminal negative amino acids.
New
So et al., Seoul, South Korea. In Pflugers Arch, Jan 2016
The inhibition was specific to TRPC4 and TRPC5 channels but was not effective to TRPC1/4, TRPC1/5, and TRPC3 channels.
Natural and synthetic flavonoid modulation of TRPC5 channels.
New
Bon et al., Leeds, United Kingdom. In Br J Pharmacol, Dec 2015
BACKGROUND AND PURPOSE: Transient Receptor Potential Canonical 5 (TRPC5) proteins assemble to create calcium-permeable non-selective cationic channels.
Calcium, TRPC channels, and regulation of the actin cytoskeleton in podocytes: towards a future of targeted therapies.
Review
New
Greka et al., Boston, United States. In Pediatr Nephrol, Nov 2015
The identification of the two Ca(2+) permeant channels TRPC5 and TRPC6 as mediators of this pathway not only bolstered the importance of podocyte cytoskeleton dynamics but also revealed promising drug targets for treatment-resistant nephrotic syndrome.
Psychiatric Disorders and TRP Channels: Focus on Psychotropic Drugs.
Review
Demirdaş et al., Isparta, Turkey. In Curr Neuropharmacol, 2014
One calcium channel family is the TRP cation channel family, which contains seven subfamilies.
Insulin excites anorexigenic proopiomelanocortin neurons via activation of canonical transient receptor potential channels.
Impact
Kelly et al., Portland, United States. In Cell Metab, 2014
Using whole-cell recording and selective pharmacological tools, we have found that, similar to leptin, purified insulin depolarized POMC and adjacent kisspeptin neurons via activation of TRPC5 channels, which are highly expressed in these neurons.
Gating of thermally activated channels.
Review
Latorre et al., Valparaíso, Chile. In Curr Top Membr, 2013
A class of ion channels that belongs to the transient receptor potential (TRP) superfamily and is present in specialized neurons that project to the skin has evolved as temperature detectors.
TRPs as chemosensors (ROS, RNS, RCS, gasotransmitters).
Review
Mori et al., Tokyo, Japan. In Handb Exp Pharmacol, 2013
The transient receptor potential (trp) gene superfamily encodes TRP proteins that act as multimodal sensor cation channels for a wide variety of stimuli from outside and inside the cell.
Constitutively active TRPC channels of adipocytes confer a mechanism for sensing dietary fatty acids and regulating adiponectin.
GeneRIF
Beech et al., Leeds, United Kingdom. In Circ Res, 2012
Adipocyte TRPC1 and TRPC5 contribute a constitutively active heteromultimeric channel that negatively regulates adiponectin, and through which the omega-3 fatty acids enhance adiponectin's anti-inflammatory activities.
TRPC5 channel is the mediator of neurotrophin-3 in regulating dendritic growth via CaMKIIα in rat hippocampal neurons.
GeneRIF
Wang et al., Shanghai, China. In J Neurosci, 2012
TRPC5 acts as a novel and specific mediator for neurotrophin (NT)-3 to regulate dendrite development through calcium/calmodulin-dependent protein kinase (CaMK)IIalpha.
Selective Gαi subunits as novel direct activators of transient receptor potential canonical (TRPC)4 and TRPC5 channels.
GeneRIF
So et al., Seoul, South Korea. In J Biol Chem, 2012
an essential role of Galpha(i) proteins as novel activators for TRPC4/5 and reveal the molecular mechanism by which G-proteins activate the channels.
Calpain cleaves and activates the TRPC5 channel to participate in semaphorin 3A-induced neuronal growth cone collapse.
GeneRIF
Clapham et al., Boston, United States. In Proc Natl Acad Sci U S A, 2012
TRPC5 acts downstream of semaphorin signaling to cause changes in neuronal growth cone morphology and nervous system development.
Gs cascade regulates canonical transient receptor potential 5 (TRPC5) through cAMP mediated intracellular Ca2+ release and ion channel trafficking.
GeneRIF
So et al., Seoul, South Korea. In Biochem Biophys Res Commun, 2012
these results suggest that the Galpha(s)-cAMP pathway potentiates the activity of TRPC5 via facilitating intracellular Ca(2+) dynamics and increasing channel trafficking to the plasma membrane.
Essential role for TRPC5 in amygdala function and fear-related behavior.
Impact
GeneRIF
Clapham et al., Boston, United States. In Cell, 2009
These experiments provide genetic evidence that TRPC5, activated via G protein-coupled neuronal receptors, has an essential function in innate fear.
TRPC channel activation by extracellular thioredoxin.
Impact
GeneRIF
Beech et al., Leeds, United Kingdom. In Nature, 2008
TRPC5 and TRPC1 are expressed in secretory fibroblast-like synoviocytes from patients with rheumatoid arthritis, and endogenous TRPC5-TRPC1 channels of the cells are activated by reduced thioredoxin
STIM1 heteromultimerizes TRPC channels to determine their function as store-operated channels.
Impact
Muallem et al., Dallas, United States. In Nat Cell Biol, 2007
Here, we report that STIM1 binds TRPC1, TRPC4 and TRPC5 and determines their function as SOCs.
Generation of functional ion-channel tools by E3 targeting.
Impact
Beech et al., Leeds, United Kingdom. In Nat Biotechnol, 2005
To test the concept, we first focused on TRPC5, a member of the transient receptor potential (TRP) calcium channel family, the study of which has been hindered by poor pharmacological tools.
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