Gating of thermally activated channels.
Valparaíso, Chile. In Curr Top Membr, 2013
A class of ion channels that belongs to the transient receptor potential (TRP) superfamily and is present in specialized neurons that project to the skin has evolved as temperature detectors.
TRPs as chemosensors (ROS, RNS, RCS, gasotransmitters).
Tokyo, Japan. In Handb Exp Pharmacol, 2013
The transient receptor potential (trp) gene superfamily encodes TRP proteins that act as multimodal sensor cation channels for a wide variety of stimuli from outside and inside the cell.
TRPC channel activation by extracellular thioredoxin.
Leeds, United Kingdom. In Nature, 2008
TRPC5 and TRPC1 are expressed in secretory fibroblast-like synoviocytes from patients with rheumatoid arthritis, and endogenous TRPC5-TRPC1 channels of the cells are activated by reduced thioredoxin
Generation of functional ion-channel tools by E3 targeting.
Leeds, United Kingdom. In Nat Biotechnol, 2005
To test the concept, we first focused on TRPC5, a member of the transient receptor potential (TRP) calcium channel family, the study of which has been hindered by poor pharmacological tools.