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proteins. Page last changed on 08 Dec 2016.
Transient receptor potential cation channel, subfamily C, member 3
The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] (from
Housley et al., Sydney, Australia. In J Neurosci, 2012
This study demonistrated that Alternative splicing of the TRPC3 ion channel has enhanced efficacy as a neuronal GPCR-Ca(2+) signaling effector, and is associated with sensorimotor coordination, neuronal development, and brain injury.
Tepel et al., Berlin, Germany. In Hypertension, 2012
Data show the expression of TRPC6 and TRPV1 was significantly increased after 24 hours of exposure to an atheroprone flow, whereas the expression of TRPC3 and TRPM7 was significantly higher in endothelial cells exposed to shear stress.