STIM and calcium channel complexes in cancer.
Cáceres, Spain. In Biochim Biophys Acta, Nov 2015
The Ca(2+)-selective store-operated current (ICRAC) is mediated by the endoplasmic reticulum (ER) Ca(2+) sensor STIM1 and the store-operated Ca(2+) (SOC) channel Orai1, while other non-selective cation currents (ISOC) involves the participation of members of the canonical transient receptor potential (TRPC) channel family, including TRPC1.
Molecular determinants of TRPC1 regulation within ER-PM junctions.
Bethesda, United States. In Cell Calcium, Oct 2015
Store-operated calcium entry (SOCE) is activated within the endoplasmic reticulum (ER)-plasma membrane (PM) junctions in the plasma membrane and involves assembly of the channels, Orai1 and TRPC1, with the regulatory protein, STIM1, in response to depletion of Ca(2+) in the ER.
Whitening Effect of Watersoluble Royal Jelly from South Korea.
South Korea. In Korean J Food Sci Anim Resour, 2014
In addition, we investigated the mRNA and protein expression of melanogenesis-related genes such as tyrosinase, tyrosinase related protein-1 (TRP-1) and TRP-2 by reverse transcription-polymerase chain reaction and western blotting.
Melanesian blond hair is caused by an amino acid change in TYRP1.
Stanford, United States. In Science, 2012
identifed an arginine-to-cysteine change at a highly conserved residue in TYRP1 as a major determinant of blond hair in Solomon Islanders; this missense mutation predicted to affect catalytic activity of TYRP1 and causes blond hair through a recessive mode of inheritance
TRPC channel activation by extracellular thioredoxin.
Leeds, United Kingdom. In Nature, 2008
TRPC5 and TRPC1 are expressed in secretory fibroblast-like synoviocytes from patients with rheumatoid arthritis, and endogenous TRPC5-TRPC1 channels of the cells are activated by reduced thioredoxin