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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Tyrosinase-related protein 1

TRPC1, TRP-1, TYRP1, tyrosinase-related protein-1
This gene encodes a melanosomal enzyme that belongs to the tyrosinase family and plays an important role in the melanin biosynthetic pathway. Defects in this gene are the cause of rufous oculocutaneous albinism and oculocutaneous albinism type III. [provided by RefSeq, Mar 2009] (from NCBI)
Top mentioned proteins: tyrosinase, CAN, V1a, Trp6, Microphthalmia-Associated Transcription Factor
Papers using TRPC1 antibodies
The roles of bud-site-selection proteins during haploid invasive growth in yeast.
Arkowitz Robert Alan, In PLoS ONE, 2001
... α ura3-52 his3-200 ade2-101 trp1-901Clontech ...
Papers on TRPC1
The involvement of TRPC1 in skeletal muscle regrowth after unloading-induced atrophy.
Yeung et al., Hong Kong, Hong Kong. In J Physiol, Feb 2016
The purpose of this investigation was to elucidate the regulatory role of the transient receptor potential canonical type 1 (TRPC1) protein during muscle atrophy and regrowth.
The functions of TRPP2 in the vascular system.
Shen et al., Hefei, China. In Acta Pharmacol Sin, Jan 2016
In cell membrane, TRPP2, along with polycystin-1, TRPV4 and TRPC1, functions as a mechanotransduction channel.
Mibefradil suppresses the proliferation of pulmonary artery smooth muscle cells.
Shen et al., Shanghai, China. In J Investig Med, Jan 2016
however, no changes in TRPC1, TRPC3, CAV1.2, and CAV3.2 levels were observed.
TRPC6 is required for hypoxia‑induced basal intracellular calcium concentration elevation, and for the proliferation and migration of rat distal pulmonary venous smooth muscle cells.
Tang et al., Nanjing, China. In Mol Med Report, Jan 2016
The results of the present study demonstrated that TRPC6 was increased in the distal PVs of CHPH rats, and in PVSMCs exposed to hypoxic conditions (4% O2, 72 h); however, TRPC1 was not.
STIM and calcium channel complexes in cancer.
Rosado et al., Cáceres, Spain. In Biochim Biophys Acta, Nov 2015
The Ca(2+)-selective store-operated current (ICRAC) is mediated by the endoplasmic reticulum (ER) Ca(2+) sensor STIM1 and the store-operated Ca(2+) (SOC) channel Orai1, while other non-selective cation currents (ISOC) involves the participation of members of the canonical transient receptor potential (TRPC) channel family, including TRPC1.
Molecular determinants of TRPC1 regulation within ER-PM junctions.
Ambudkar et al., Bethesda, United States. In Cell Calcium, Oct 2015
Store-operated calcium entry (SOCE) is activated within the endoplasmic reticulum (ER)-plasma membrane (PM) junctions in the plasma membrane and involves assembly of the channels, Orai1 and TRPC1, with the regulatory protein, STIM1, in response to depletion of Ca(2+) in the ER.
An intelligent nano-antenna: Primary cilium harnesses TRP channels to decode polymodal stimuli.
Inoue et al., Baltimore, United States. In Cell Calcium, Oct 2015
In this review, we will first recapitulate the molecular basis of the polymodal sensory function of the primary cilia, specifically focusing on transient receptor potential (TRP) channels that accumulate inside the organelle and conduct calcium ions (Ca(2+)).
The Roles of Rasd1 small G proteins and leptin in the activation of TRPC4 transient receptor potential channels.
So et al., Seoul, South Korea. In Channels (austin), 2014
Much is known regarding the assembly and function of these channels including TRPC1 as a homotetramer or a heteromultimer and the roles that their interacting proteins play in controlling these events.
Using Centromere Mediated Genome Elimination to Elucidate the Functional Redundancy of Candidate Telomere Binding Proteins in Arabidopsis thaliana.
Riha et al., Vienna, Austria. In Front Genet, 2014
Here we performed genetic analysis on the TRF-like family consisting of six proteins (TRB1, TRP1, TRFL1, TRFL2, TRFL4, and TRF9) which have previously shown to bind telomeric DNA in vitro.
Whitening Effect of Watersoluble Royal Jelly from South Korea.
Pak et al., South Korea. In Korean J Food Sci Anim Resour, 2014
In addition, we investigated the mRNA and protein expression of melanogenesis-related genes such as tyrosinase, tyrosinase related protein-1 (TRP-1) and TRP-2 by reverse transcription-polymerase chain reaction and western blotting.
On the role of TRPC1 in control of Ca2+ influx, cell volume, and cell cycle.
Hoffmann et al., Copenhagen, Denmark. In Am J Physiol Cell Physiol, 2012
TRPC1 is upregulated in G1 phase as compared with S phase, concomitant with an increased rate of regulatory cell volume decrease.
Polyamines regulate intestinal epithelial restitution through TRPC1-mediated Ca²+ signaling by differentially modulating STIM1 and STIM2.
Wang et al., Baltimore, United States. In Am J Physiol Cell Physiol, 2012
It was shown that polyamines regulate intestinal epithelial restitution through TRPC1-mediated Ca2+ signaling by altering the ratio of STIM1 to STIM2. Overexpression of ornithine decarboxylase resulted in increased STIM1 but decreased STIM2 expression.
Constitutively active TRPC channels of adipocytes confer a mechanism for sensing dietary fatty acids and regulating adiponectin.
Beech et al., Leeds, United Kingdom. In Circ Res, 2012
Adipocyte TRPC1 and TRPC5 channel subunits contribute a constitutively active heteromultimeric channel that negatively regulates adiponectin, and through which the omega-3 fatty acids enhance adiponectin's anti-inflammatory activities.
A TRPC1-mediated increase in store-operated Ca2+ entry is required for the proliferation of adult hippocampal neural progenitor cells.
Yu et al., Chongqing, China. In Cell Calcium, 2012
The suppression of TRPC1 expression arrested the adult neural progenitor cell cycle at G0/G1 phase.
Melanesian blond hair is caused by an amino acid change in TYRP1.
Myles et al., Stanford, United States. In Science, 2012
identifed an arginine-to-cysteine change at a highly conserved residue in TYRP1 as a major determinant of blond hair in Solomon Islanders; this missense mutation predicted to affect catalytic activity of TYRP1 and causes blond hair through a recessive mode of inheritance
Essential role for TRPC5 in amygdala function and fear-related behavior.
Clapham et al., Boston, United States. In Cell, 2009
The transient receptor potential channel 5 (TRPC5) is predominantly expressed in the brain where it can form heterotetrameric complexes with TRPC1 and TRPC4 channel subunits.
ASIP and TYR pigmentation variants associate with cutaneous melanoma and basal cell carcinoma.
Stefansson et al., Reykjavík, Iceland. In Nat Genet, 2008
An eye color variant in TYRP1 was associated with risk of cutaneous melanoma.
TRPC channel activation by extracellular thioredoxin.
Beech et al., Leeds, United Kingdom. In Nature, 2008
TRPC5 and TRPC1 are expressed in secretory fibroblast-like synoviocytes from patients with rheumatoid arthritis, and endogenous TRPC5-TRPC1 channels of the cells are activated by reduced thioredoxin
STIM1 heteromultimerizes TRPC channels to determine their function as store-operated channels.
Muallem et al., Dallas, United States. In Nat Cell Biol, 2007
Here, we report that STIM1 binds TRPC1, TRPC4 and TRPC5 and determines their function as SOCs.
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